Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China

Abstract

Detection of asymptomatic or subclinical novel human coronavirus SARS-CoV-2 infection is critical for understanding the overall prevalence and infection potential of COVID-19. To estimate the cumulative prevalence of SARS-CoV-2 infection in China, we evaluated the host serologic response, measured by the levels of immunoglobulins M and G in 17,368 individuals, in the city of Wuhan, the epicenter of the COVID-19 pandemic in China, and geographic regions in the country, during the period from 9 March 2020 to 10 April 2020. In our cohorts, the seropositivity in Wuhan varied between 3.2% and 3.8% in different subcohorts. Seroposivity progressively decreased in other cities as the distance to the epicenter increased. Patients who visited a hospital for maintenance hemodialysis and healthcare workers also had a higher seroprevalence of 3.3% (51 of 1,542, 2.5-4.3%, 95% confidence interval (CI)) and 1.8% (81 of 4,384, 1.5-2.3%, 95% CI), respectively. More studies are needed to determine whether these results are generalizable to other populations and geographic locations, as well as to determine at what rate seroprevalence is increasing with the progress of the COVID-19 pandemic. Serologic surveillance has the potential to provide a more faithful cumulative viral attack rate for the first season of this novel SARS-CoV-2 infection.The novel human coronavirus SARS-CoV-2 is a highly contagious virus, and its disease, COVID-19, can lead to significant morbidity and mortality in a proportion of patients 1-3 . On 12 March 2020, the World Health Organization declared it a global pandemic 4 . As of 12 May 2020, there were more than 4.2 million confirmed infections globally in more than 180 countries with over 290,000 deaths (https://www.arcgis.com/apps/opsdashboard/index.html#/ bda7594740fd40299423467b48e9ecf6).Detection of SARS-CoV-2 in asymptomatic individuals 5,6 suggests that subclinical active infection might be an important contributor to this outbreak. Currently, reported cases of COVID-19 are mainly limited to symptomatic individuals, those having close

Driving Force of Covid-19 Among People Living With HIV/AIDS in Wuhan, China

“…In this study, the age of COVID-19/PLWHA was older than the other PLWHA, which was consistent with that in the overall COVID-19 population, i.e., the older males had a higher proportion in the COVID-19 patients [2]. Furthermore, our study suggested that older age was a risk factor for HIV/AIDS suffered COVID-19, which was also similar to the HIV negative population [19].…”

“…The multivariable results also indicated that the log transferred CD4 count was negatively associated with the occurrence of COVID-19 (AOR=0.06, 95%: CI 0.01-0.30), while log transferred length from HIV diagnosis was positively associated with the occurrence of COVID-19 (AOR=1.12, 95% CI:1.05-1. 19).…”

“…The distribution of patients with COVID-19 and patients with HIV/AIDS in four districts, Wuhan. The distribution of all documented, laboratory-con rmed cases of coronavirus disease 2019 (COVID-19), and all documented patients with HIV/AIDS in Wuchang, Qingshan, Caidian and Xinzhou n districts, Wuhan was shown in the gure, according to the o cial management system of Center for Disease Control and Prevention of Hubei province by May 14, 2020. Note: The designations employed and the presentation of…”

Maternal SARS-CoV-2 IgG provides limited protection for their infants

“…This is not on par with the dynamic regularity of antibodies in other viral infection. Many similar results have reported that the serum antibodies dynamic of this novel virus surprised all of us 17,[21][22][23] .We also found that without breast feeding, the maternal protective effect in infants was rapidly eliminated naturally within two months after birth ( Table 3). It is worth noting that this rate of decline was beyond expectations.…”

High-Accuracy Multiplexed SARS-CoV-2 Antibody Assay with Avidity and Saliva Capability on a Nano-Plasmonic Platform

“…High specificity is critical to avoid misinterpretations or false positives, unnecessary stress and quarantine, and to prevent controversies and wrong conclusions for surveillance or prevalence studies [23][24][25][26][27][28][29] . On the other hand, currently no antibody avidity test 7,[30][31][32][33][34] exists for COVID-19 to assess the antibody maturation and infer the timing of recent as opposed to remote infection.…”