Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in Cyprus

Papaneophytou, Christos; Nicolaou, Andria; Pieri, Myrtani; Nicolaidou, Vicky; Galatou, Eleftheria; Sarigiannis, Yiannis; Pantelidou, Markella; Panayi, Pavlos; Thoma, Theklios; Stavraki, Antonia; Argyrou, Xenia; Kalogiannis, Tasos; Yiannoukas, Kyriacos; Petrou, Christos; Felekkis, Kyriacos

doi:10.1371/journal.pone.0269885

Cited by 2 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ali et al, report higher IgG, IgA, and neutralizing antibodies in the vaccinated with prior infection [24]. Similar results were also reported by Demonbreun et al and Pantelidou et al, with higher values of median IgG and neutralization rate as compared to the non-infected patients [25], [26].…”

Section: Discussionsupporting

confidence: 70%

Quantitative SARS-CoV-2 Spike Receptor-Binding Domain on Vaccinated Individuals Compared to Natural Infection

Lihawa,

Datau,

Surachmanto

et al. 2023

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic has been going on for more than 2 years, with various treatments and diagnostic methods available. One of the most prized structures, the receptor-binding domain (RBD) of the spike protein in severe acute respiratory syndrome coronavirus 2 has long been thoroughly researched for its function and becoming the target for various diagnostic methods and treatments, including a vaccine. The spike-RBD (sRBD) antibody count might be the parameter for antibody response in vaccinated and infected individuals. However, no direct comparison is made. AIM: The study aims to compare the sRBD antibody count in the naturally infected individuals to the vaccinated ones. METHODS: We conducted a cross-sectional study with 49 participants of the infected patients, and vaccinated individuals were included in this study from Prof. Dr. R. D. Kandou Hospital, Manado. The participants underwent a COVID-19 antibody test, using enhanced “Chemiluminescence” Immuno assay to analyze the anti-sRBD IgG quantitatively. Results were then analyzed and compared using IBM Statistical Package for Social Sciences ver 25.0 with Mann−Whitney non-parametric test. RESULTS: The study shows a higher median antibody count in the naturally infected group compared to the vaccinated group (132.70 vs. 11.95 U/mL; p < 0.001). Further studies on the topic should be conducted to determine the comparison on a larger scale. CONCLUSION: The s-RBD antibody titer is significantly higher in naturally infected patients than in vaccinated individuals.

show abstract

Section: Discussionsupporting

confidence: 70%

Quantitative SARS-CoV-2 Spike Receptor-Binding Domain on Vaccinated Individuals Compared to Natural Infection

Lihawa,

Datau,

Surachmanto

et al. 2023

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…In addition, another study on the efficacy of vaccination in adults showed that among vaccinated individuals with prior evidence of infection, there were no significant differences in IgG levels between males and females across all age groups ( 22 ). Another study on seroprevalence of IgG antibody against SARS-CoV-2 conducted in Cyprus showed that, without evidence of prior infection, anti-spike IgG antibodies were detected after injection of 2 doses of mRNA vaccines in 91.2% participants, while antibody levels showed a decrease at 120 days after vaccination ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study

Dai

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

ObjectiveTo analyze the positivity and levels of SARS-CoV-2 antibodies in vaccinated children to evaluate the humoral immune response of vaccination on pediatric population. Analysis on the causes of antibody positivity in unvaccinated children.MethodsA retrospective study was conducted on children who were admitted to the Children’s Hospital Affiliated to Capital Institute of Pediatrics. The clinical data of serological testing of SARS-CoV-2 immunoglobulin M (IgM) and IgG antibodies were collected from SARS-CoV-2 vaccinated or unvaccinated children with no evidence of prior novel coronavirus infection. Chemiluminescence immunoassay was utilized for the in vitro determination of SARS-CoV-2 antibodies.ResultsA total of 3,321 healthy children aged 6-11 years received two doses of inactivated SARS-CoV-2 vaccine. At 1 month after the second dose, the positive rate (96.5%) and levels [8.039 (interquartile range (IQR), 6.067-9.098)] of SARS-CoV-2 IgG antibodies reached the peak and remained at a high level for 2-3 months, after which the positive rate and level of vaccine-induced IgG antibody gradually decreased. Compared with 1 month after the second dose of vaccine, the positive rate of IgG antibody decreased to 70.4% at 7 months, and the antibody level decreased by 69.0%. A total of 945 children aged 3-5 years received one or two doses of inactivated vaccine. The positive rate and levels of SARS-CoV-2 IgG antibody in participants remained high for 3 months after vaccination. There was no gender-based difference in positive rate of IgG antibody in children aged 3-11 years old (P>0.05). Among the 5,309 unvaccinated children aged 0 day to 11 years, 105 (2.0%) were positive for SARS-CoV-2 IgG antibody, which was associated with passive infusion. The maternal humoral response to COVID-19 vaccination in noninfected pregnant women was transferred through the placenta to the fetus, and some children obtained SARS-CoV-2-positive antibodies through blood transfusion.ConclusionsInactivated SARS-CoV-2 vaccines could induce robust humoral immune response that gradually declined within several months after the second dose. Therefore, it helps to determine whether children receive a booster dose and elicit a long-term memory immune response. Positive SARS-CoV-2 antibodies in unvaccinated children were associated with passive IgG antibody infusion.

show abstract

Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in Cyprus

Cited by 2 publications

References 45 publications

Quantitative SARS-CoV-2 Spike Receptor-Binding Domain on Vaccinated Individuals Compared to Natural Infection

Quantitative SARS-CoV-2 Spike Receptor-Binding Domain on Vaccinated Individuals Compared to Natural Infection

Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study

Contact Info

Product

Resources

About