Seroprevalence ofToxoplasma gondiiin Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran

Abstract

Toxoplasma gondii is an obligate intracellular protozoan parasite causing toxoplasmosis in animals and humans. Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission to the fetus. However it is not certain whether Toxoplasma infection can cause recurrent abortion. The aim of this study was to determine the relationship between Toxoplasma infection and abortion via detection of anti-Toxoplasma gondii antibodies in sera of women with obstetrical problems and compare the results with control group consisting of women with history of normal delivery. Sera from 130 women with abortion and sera of 130 women with normal delivery were tested for IgG and IgM anti-Toxoplasma gondii antibodies by ELISA method. The present study revealed 24.6% of the samples with abortion and 21.5% of the samples with normal delivery were positive for IgG antibodies. However, statistical analysis indicated no significant differences (P > 0.05). In addition, IgM antibody was detected in one woman who had aborted but not in women with normal childbirth. This study showed no significant difference between the case and control groups in IgG anti-Toxoplasma antibody but detected one sample with IgM antibodies in woman with abortion during the first trimester of pregnancy. In order to determine the relationship between Toxoplasma infection and abortion, anti-Toxoplasma IgG avidity and PCR to discriminate between recent and prior infections are recommended.

Seroprevalence of toxoplasmosis in diabetic pregnant women in southwestern of Iran

“…For example, the prevalence rate of T. gondii in pregnant women in Portugal is 59.8 % and in pregnant women in Turkey (52.1 %) (Ocak et al 2007;Varella et al 2003). In addition, this coccidian protozoan is widely distributed in Iran and the prevalence rate in Khuzestan ranged from 21.5 to 47.25 % (Daryani et al 2014;Khademvatan et al 2013;Saki et al 2013Saki et al , 2015Soltani et al 2013;Yad et al 2014). It seems that the oocytes excreted by cats find the opportunity to become infectious due to its warm-humid seasons in khuzestan (Khademvatan et al 2014).…”

“…Appropriate diagnosis of toxoplasmosis is crucial among the persons: Pregnant women who have acquired this infection during pregnancy, infants who have congenitally acquired toxoplasmosis during the prenatal period, patients with weakened immune system, and chorioretinitis patients (Ghasemian et al 2007;Saki et al 2015). The probability of prenatal transmission increases as the fetal age increases; so that it is 10-15, 30-54 and 60-65 % during the first, second and third trimesters of pregnancy, respectively.…”

Estimation of Toxoplasma gondii infection by Serological and Immunohistochemical methods in Baghdad City-Iraq

“…In Babylon, by ELISA method, anti -Toxoplasma IgG, IgM, were 18.09% and 9.79%, respectively(Kadhimand Mohammed, 2013).While the rate of Toxoplasma seropositivity in Erbil was higher using LAT 54.46%, followed by ELISA IgG 37.5%, and IgM 9.13% (Hamad and Kadir, 2013).In Zanjan, Northwest of Iran 38.6%, the IgM and IgG were positive in 1.4% and 37.2% respectively(Hajsoleimaniet al, 2012), while in Ahvaz, Southwest of Iran, 24.6% of the samples with abortion and 21.5% of the samples with normal delivery were positive for IgG antibodies. However, statistical analysis indicated no significant differences at P>0.05 (Saki, 2015).In Turkey, the prevalence of toxoplasmosis was determined to be 58.3% and 1% for IgG and IgM, respectively (Yentur, 2015).This variation might be attributed to climate, cultural differences regarding hygienic and feeding habits.…”

Cytogenetic Studies on Lymphocytes Isolated from Women with a History of Abortion Infected with Toxoplasma gondii

“…Those women were divided into three groups according to the presence or absence of specific anti-Toxoplasma antibodies. These groups included women with IgG (18), women with IgM (14) and women with both IgG and IgM (12). The other 16 women had no antibodies against Toxoplasma.…”

“…Studies carried out in Scandinavian countries [10] and in England [11] have shown low levels of seroprevalence. In other countries, toxoplasmosis had been investigated such as in Iran [12], Saudi Arabia [13] and in Egypt [14]. In Iraq, many studies were published about the seroprevalence of toxoplasmosis by using different techniques like IHA, IFAT and ELISA [15,16].…”