Seroprevalence of <i>Toxocara</i> infection in children and environmental contamination of urban areas in Paraná State, Brazil

Mattia, Salete; Colli, Cristiane Maria; Adami, Carolina Moreira; Guilherme, Gomes; Nishi, Letícia; Rubinsky-Elefant, Guita; Marchioro, Ariella Andrade; Gomes, Mônica Lúcia; Falavigna-Guilherme, Ana Lúcia

doi:10.1017/s0022149x11000666

Cited by 26 publications

(33 citation statements)

References 28 publications

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“…Previous seroepidemiological studies involving children attending regional BHUs in the Brazilian state of Paraná have reported seropositivity rates between 32.2% and 56.0% 1,5,14,15,17,18 . However, in our study, only seven out of 167 children (4.2%) showed anti-Toxocara spp.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies in this region have reported that eosinophilia is present in 7.8% (30/386) 1,5,14,15,17,18 . In this study, we have observed two cases of moderate eosinophilia in patients with anti-Toxocara spp.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to Toxocara spp. in childhood is a very common condition in our region 1,5,15,17 and it is expected that this could result in an increased demand for specialized pulmonary disease services. Nevertheless, this is not the case.…”

Section: Discussionmentioning

confidence: 99%

“…In the nine cities investigated (Astorga, Colorado, Mandaguaçu, Mandaguari, Marialva, Maringá, Nova Esperança, Paiçandu, and Sarandi), we have observed that the seroprevalence of toxocariasis varies from 32.2% to 56% 1,5,14,15,17,18 . Among the signs and symptoms analyzed, pulmonary ones were the most reported 1,5,14,15,17,18 . Therefore, the aims of this work were to verify whether the rates of toxocariasis frequency found in our previous research was repeated in children referred to the public pneumology service, and describe the laboratorial, clinical and epidemiological findings of the seropositive children.…”

Section: Introductionmentioning

confidence: 94%

“…The CISAMUSEP receives children referred by BHUs and other health services in 30 cities. The results were compared with the epidemiological data of children from the same region using previous reported studies 1,5,14,15,17,18 .…”

Section: Samplingmentioning

confidence: 99%

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Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Guilherme¹,

Marchioro

Araújo³

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe enzyme-linked immunosorbent assay (ELISA) is the most widely used tool to detect anti-Toxocara IgG antibodies for both serodiagnostic and seroepidemiological surveys on human toxocariasis. In the last eight years a high prevalence of toxocariasis (32.2-56.0%) has been reported in children attending public health units from municipalities in the state of Paraná, Brazil. Therefore, the aim of this work was to compare the frequency found among the general child population with that of children attending a public pneumology service in Maringá, Paraná, Brazil and describe the laboratorial, clinical and epidemiological findings. The research was conducted at the Consórcio Público Intermunicipal de Saúde do Setentrião Paranaense (CISAMUSEP) from July 2009 to July 2010 among children aged between one and 15 years. From a total of 167 children studied, only 4.2% (7/167) tested positive for anti-Toxocara spp. IgG antibodies and presented mild eosinophilia (2/7), increased serum IgE levels (6/7) and a positive allergy test for mites (5/7). The presence of pets (dogs or cats) at home did not correlate with the seroprevalence. In conclusion, cases of toxocariasis involving the respiratory tract are rare in children attending a public health pneumology unit in the northwestern region of Paraná State, despite the high prevalence of this type of toxocariasis among the infantile population attending Basic Health Units in the same geographical area.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Samplingmentioning

confidence: 99%

See 3 more Smart Citations

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Guilherme¹,

Marchioro

Araújo³

et al. 2013

Rev. Inst. Med. trop. S. Paulo

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Lactobacillus rhamnosus reduces parasite load on Toxocara canis experimental infection in mice, but has no effect on the parasite in vitro

et al. 2017

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Human toxocariasis is a neglected global parasitic zoonosis. The efficacy of drug treatment for this disease has been hindered by the biological complexity of the main etiological agent, the nematode Toxocara canis. Experimental studies have shown the potential of probiotics to promote a reduction in the parasite load of T. canis larvae. This study aimed to evaluate the effect of probiotic Lactobacillus rhamnosus ATCC 7469 on the parasite load of BALB/c mice with acute toxocariasis and evaluate the direct effect of this probiotic on T. canis larvae in vitro. In vivo administration of probiotics reduced the parasite load of T. canis larvae by 53.3% (p = 0.0018) during the early stage of infection in mice. However, when analyzed in vitro, it was observed that the probiotic did not present a deleterious effect on the larvae, as approximately 90% of these remained viable. These results demonstrate the potential of the probiotic L. rhamnosus in the reduction of T. canis larvae in BALB/c mice and suggest it could be used as an alternative means for the controlling of visceral toxocariasis. However, further studies are required to elucidate the mechanisms of action promoted by this probiotic.

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Visceral Larva Migrans Syndromes Associated with Toxocariasis: Epidemiology, Clinical and Laboratory Aspects of Human Toxocariasis

Carvalho¹,

Rocha²

2014

Curr Trop Med Rep

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Toxocariasis is caused by the helminth Toxocara spp. Its prevalence is underestimated in many settings and affects primarily children due to their vulnerability. Toxocariasis may be an asymptomatic infection or it may progress to cause severe clinical forms. The aim of this paper is to describe the epidemiology, risk factors, clinical and laboratory diagnosis of visceral larva migrans that manifest in the liver, lung, or central nervous system. It is recommended that antiparasitic treatment should be instituted even in asymptomatic patients to prevent migration of the larva to vital organs. There is a lack of awareness of the population of this parasitic infection and also among clinicians regarding the clinical manifestations of toxocariasis. The lack of public health preventive measures leads to its high prevalence in many settings, usually impoverished areas in tropical settings. Thus, it is imperative to prevent transmission and to provide early treatment of asymptomatic or symptomatic cases to prevent complications and late sequelae of this parasitic infection.

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Seroprevalence of Toxocara infection in children and environmental contamination of urban areas in Paraná State, Brazil

Cited by 26 publications

References 28 publications

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Toxocariasis in children attending a Public Health Service Pneumology Unit in Paraná State, Brazil

Lactobacillus rhamnosus reduces parasite load on Toxocara canis experimental infection in mice, but has no effect on the parasite in vitro

Visceral Larva Migrans Syndromes Associated with Toxocariasis: Epidemiology, Clinical and Laboratory Aspects of Human Toxocariasis

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