Seroprevalence of human T-lymphotropic virus antibodies among patients with lymphoid malignancies at a tertiary center in Lagos, Nigeria

Akinbami, Akinsegun; Durojaiye, Idris; Dosunmu, Adedoyin; John‐Olabode, Sarah; Adediran, Adewumi; Oshinaike, Olajumoke; Uche, Ebele; Dada, Akinola; Odesanya, Mojeed; Okunoye, Olaitan

doi:10.2147/jbm.s67912

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Furthermore, the findings from this review also show the predominance of infected males as against females widely reported elsewhere. This is consistent with epidemiological studies that show the prevalence of HTLV to vary along sex and reported a higher infection rate in African men or men of African descent [ 39 - 41 ]. This could suggest an etiological factor such as perinatal infectivity as against the transfusion transmission route.…”

Section: Discussionsupporting

confidence: 92%

“…The clinical etiological implications of where HTLV-1 infection will be a necessary diagnostic criterion remain largely unclear. Characterized neurological syndromes in the tropics have been classified as tropical myeloneuropathies and grouped into tropical ataxic neuropathy or TSP [ 39 ]. However, our brief review of the literature shows the involvement of HTLV-1 infection although the route of transmission could not be verified.…”

Section: Discussionmentioning

confidence: 99%

“…This could suggest an etiological factor such as perinatal infectivity as against the transfusion transmission route. It is imperative to state here that excessive consumption of cassava containing cyanogenic glycosides is a major etiological factor associated with myelopathy, especially tropical ataxic neuropathies in southern states of Nigeria with the highest consumption as compared to the northern regions where zero studies have been reported [ 39 ]. Thus, this could complicate the course of disease progression and the incidence of myelopathy.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature

Usman¹,

Musa²,

Shuaib³

et al. 2023

Clin Exp Pediatr

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The peripartum period is both a highly vulnerable stage and a significant indicator of a population's health status. Interest is increasing in Human T-cell leukemia virus type-1 (HTLV-1) transmission due to its adverse health impacts. However, nationally representative data on HTLV-1 that are important for health planning are unavailable for this subpopulation.This study aimed to conduct a pooled estimate of HTLV-1 prevalence among pregnant women in Nigeria to quantify its clinical burden and public health implications. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 statement. After a systematic review of the Nigerian literature, 12 studies (2821 pregnant or postnatal women) were included in the final evidence synthesis. The estimated HTLV-1 prevalence in Nigerian peripartum women following a positive screening test by enzyme-linked immunosorbent assay was 5.44% (95% confidence interval [CI], 3.16-9.20%). A subgroup analysis of the two major regions showed a slightly higher prevalence in the Western versus Southern region (5.55% [95% CI, 2.49-11.87%]; and 4.91% [95% CI, 2.11-11.02]; P = 0.84). However, a subgroup analysis by geopolitical zone revealed that Southwestern and Northwestern Nigeria had the highest prevalence (9.23% [95% CI, 4.35-18.55; I 2 , 93%] and 7.15% [95% CI, 1.54-27.54]; I 2 , 92%).Our decade-old subgroup analysis found inconsistencies in the HTLV-1 prevalence. Furthermore, our literature review revealed a prevalence of HTLV infection among patients with various clinical types of lymphomas/leukemias and myelopathy of 2-22%. These findings have important implications in defining the epidemiological patterns of HTLV-1 infection in Nigeria. They also suggest the presence of HTLV-endemic clusters near lowendemic areas, even within the same geopolitical zones.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature

Usman¹,

Musa²,

Shuaib³

et al. 2023

Clin Exp Pediatr

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Prevalence of human T-lymphotropic virus 1/2 in Nigeria’s capital territory and meta-analysis of Nigerian studies

et al. 2019

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Objectives: This study was aimed at determining human T-lymphotropic virus 1/2 prevalence among apparently healthy, immunocompromised and haematologic malignant individuals in Nigeria’s capital, as well as meta-analysis of all Nigerian studies until date. Methods: A total of 200 participants were recruited into a cross-sectional study. In total, 1 mL each of sera and plasma were obtained from 5 mL blood of each participant and analysed for antibodies to human T-lymphotropic virus 1/2 using enzyme-linked immunosorbent assay; positive samples confirmed with qualitative real-time polymerase chain reaction, followed by statistical and meta-analysis. Sociodemographic characteristics and possible risk factors were assessed via questionnaires. Results: Enzyme-linked immunosorbent assay yielded 1% prevalence which was confirmed to be zero via polymerase chain reaction. A total of 119 (59.5%) of the participants were male, while the mean age was 35.28 ± 13.61 years. Apart from sex and blood reception/donation, there was generally a low rate of exposure to human T-lymphotropic virus–associated risk factors. Meta-analysis revealed pooled prevalence of human T-lymphotropic virus 1 and 2 to be 3% and 0%, respectively, from Nigerian studies. Conclusion: This study discovered zero prevalence of human T-lymphotropic virus 1/2 from five major hospitals in Nigeria’s capital, exposing the importance of confirmatory assays after positive antibody detection assay results. Meta-analysis highlighted the existence of very few reliable Nigerian studies compared to the demography of the nation. Large-scale epidemiological studies and routine screening of risk populations are therefore needed since Nigeria lies in the region of endemicity.

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Haematological Malignancies in Nigeria: Challenges in Diagnosis and Management – A Systematic Review.

Ugwu¹,

Nwannadi²

2020

J BioMed Res Clin Pract

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Haematological malignancies are major cause of mortality and morbidity worldwide. The aim of this review was to summarize some of the challenges that hamper proper diagnosis and management of haematological malignancies in Nigeria and how they affect outcome. MEDLINE Entrez PubMed, Google scholar and African Journals Online (AJOL) search were performed in April 2020 and studies that investigated challenges in diagnosis and management of haematological malignancies from 2005 to 2019 were sought. Search keywords included “haematological malignancies, challenges, Nigeria”. Only studies that provided information on the challenges of diagnosis and management of haematological malignancies in Nigeria were eligible and were selected. Inclusion criteria were original scientific investigations or case reports, not reviews, studies conducted in Nigeria between 2005 and 2019 and studies written in the English language. A total of eight relevant studies that fulfilled the study inclusion criteria were identified out of 4,129 studies found. Challenges of diagnosis and management of haematological malignancies reported by the studies include late presentation of patients in advanced stage of disease, inability to pay for investigations and/or treatment due to financial constraint, wrong/ delayed diagnosis due to poor diagnostic facility such as use of only morphology for histological diagnosis without immunohistochemistry and poorly equipped health facilities to manage haematological malignancies. Poor outcome as a result of those challenges were also reported by the studies. Awareness creation and education on the importance of early presentation to health facility should be encouraged. Health system should be strengthened by including haematological malignancies in National Health Insurance and providing well equipped health facility for proper diagnosis and management of haematological malignancies.

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Seroprevalence of human T-lymphotropic virus antibodies among patients with lymphoid malignancies at a tertiary center in Lagos, Nigeria

Cited by 4 publications

References 27 publications

Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature

Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature

Prevalence of human T-lymphotropic virus 1/2 in Nigeria’s capital territory and meta-analysis of Nigerian studies

Haematological Malignancies in Nigeria: Challenges in Diagnosis and Management – A Systematic Review.

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