Seroprevalence of human parvovirus B19 in healthy blood donors

Kumar, Satish; Gupta, R.M.; Sen, Sourav; Sarkar, Rik; Philip, Joseph; Kotwal, Atul; Sumathi, S

doi:10.1016/j.mjafi.2012.11.009

Cited by 22 publications

(16 citation statements)

References 25 publications

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“…Viral load was no detected in some controls with IgG or IgM/IgG antibodies. In this regard, it has been reported that immunocompetent individuals produce antibodies that effectively eliminate viremia within a few days of infection, and the infection is often not developed, is asymptomatic or has mild clinical manifestations (like the common cold) 55 , which seems to agree with what we found in our controls. On the other hand, there have also been rare cases of chronic PV-B19 infection in healthy individuals, with involvement of the central nervous system, causing nonspecific symptoms such as fatigue, fever, arthralgia and myalgia, which may hinder the diagnostic 56 .…”

Section: Discussionsupporting

confidence: 93%

“…La carga viral no se detectó en algunos controles con anticuerpos IgG o IgM / IgG. A este respecto, se ha reportado que los individuos inmunocompetentes producen anticuerpos que eliminan efectivamente la viremia a los pocos días de la infección, y la infección no suele desarrollarse, es asintomática o tiene manifestaciones clínicas leves (como el resfriado común) 55 , lo que parece correlacionar con lo que encontramos en nuestros controles. Por otra parte, también se han registrado casos raros de infección crónica por PV-B19 en individuos sanos, con afectación del sistema nervioso central, causando síntomas inespecíficos como fatiga, fiebre, artralgia y mialgia, lo que puede dificultar el diagnóstico 56 .…”

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Serological and molecular analysis of parvovirus B19 infection in Mayan women with systemic lupus erythematosus in Mexico.

et al. 2017

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Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that mainly affects women, characterized by the production of autoantibodies. Its causal agent is unknown, but the combination of environmental, hormonal and genetic factors may favor the development of the disease. Parvovirus B19 has been associated with the development of SLE, since it induces the production of anti-single stranded DNA antibodies. It is unknown whether PV-B19 infection is an environmental factor that trigger or reactivate SLE in the Mexican Mayan population. Aim: A preliminary serological and molecular study of PV-B19 infection in Mayan women with established SLE was done. Methods: IgG and IgM anti PV-B19 were evaluated in 66 SLE patients and 66 control subjects, all women of Mayan origin. Viral DNA and viral load were analyzed by qPCR. Results: Insignificant levels of IgM were observed in 14.3% (4/28) of the patients and 11.4% (4/35) of control subjects. IgG was detected in 82.1% (23/28) of the patients and 82.9% (29/35) of control subjects, but were significantly higher in patients. Viral DNA was found in 86.0% (57/66) of the patients and 81.0% (54/66) of control subjects. Viral load, quantified in 28/66 patients and 31/66 controls which were positive for IgM and IgG, was significantly higher in controls. Conclusion: The high prevalence of PV-B19 in Yucatan, and the presence of IgM, IgG, and viral load in Mayan women with established SLE suggest that PV-B19 infection could be an environmental factor to trigger or reactivate SLE.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionunclassified

Serological and molecular analysis of parvovirus B19 infection in Mayan women with systemic lupus erythematosus in Mexico.

et al. 2017

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“…We detected a seroprevalence of 62.2% and the positivity of IgM was 0.06% in SANBS blood donors which is comparable with the seroprevalence in other reports . Varying PVB19 IgG prevalence has been reported ranging from 6% to 82.3% .…”

Section: Discussionsupporting

confidence: 88%

Parvovirus B19 in South African blood donors

Francois

Parboosing

Moodley

2019

Journal of Medical Virology

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Background: Parvovirus B19 (PVB19) is transmitted via transfusion of blood and blood products. PVB19 is resistant to viral inactivation methods, which poses a threat to blood safety. We investigated the prevalence of PVB19 antibodies and DNA in healthy blood donors from the South African National Blood Bank Service to evaluate the necessity of PVB19 DNA testing. Study Design and Method: A retrospective analysis of 1500 residual plasma specimens from healthy blood donors from the SANBS repository were screened in mini-pools of 20 for PVB19 DNA using a quantitative polymerase chain reaction (PCR). Positive pools were resolved by individual viral load testing and screened for PVB19 immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies to correlate viral loads with serological status. PVB19 IgG prevalence was determined by testing 90 randomly selected specimens from the 1500 plasma specimens. Results: The prevalence of PVB19 IgG, IgM and IgG, and DNA was 62.2%, 0.06%, and 0.9%, respectively. Fourteen of the 1500 blood donor specimens received, had detectable PVB19 viral loads. Nine of the fourteen donors with detectable viral loads were PVB19 IgG seropositive. The PVB19 viral loads ranged from 1.81 to 5.32 log IU/mL. Four of the fourteen viraemic donors had a viraemia >10 4 IU/mL. Conclusion: We have demonstrated a low prevalence of PVB19 DNA in SANBS blood donors. The predominance of low-level viraemia and the presence of PVB19 antibodies, suggests that the risk of transfusion transmission of PVB19 among SANBS donors may be relatively low.

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“…B19 infection can lead to serious consequences in ‘at risk’ groups, such as organ transplant recipients, thalassaemia and sickle cell anaemia patients and foetus in utero 6 . There are no population-based seroprevalence studies from India on parvovirus B19, although studies conducted among blood donors 7 8 and hospital-based studies 9 are reported. Seroprevalence data of B19 in pregnant women are also lacking from India.…”

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confidence: 99%