Seroprevalence of HTLV I-II, HIV and HCV Antibodies in Lymphoma, Head and Neck Cancer Patients

Abstract

Human T-cell lymphotropic virus type I (HTLV I), which has a worldwide distribution, is the first human retrovirus mainly to be associated with malignant diseases, such as adult T-cell leukemia-lymphoma and bronchioloalveolar carcinoma. Tip II (HTLV II), a retrovirus having genomic homology with the HTLV I, has not been proven to be a pathogenic virus so far. Hepatitis C virus (HCV), an RNA virus, is the cause of acute and chronic hepatitis, cirrhosis and liver cancer. Human immunodeficiency virus (HIV syn. HTLV III), is a factor in AIDS. Studies on the development of malignant diseases of these viruses are restricted in all over the world, there is no detailed study was found in our country as well. In this study, the seropositivity of HTLV I-II, HIV and HCV viruses in lymphoma and head and neck cancer patients and the relationship between these viruses and these cancers evaluated. As a result HTLV I-II seropositivity was found in 2 of 86 lymphoma and 2 of 80 head and neck cancer patients. There is a need for further large studies related to those and other viral agents caused malignancies. Keywords: HTLV, HIV, HCV, Lymphoma, Head and neck carcinoma ÖZET Lenfoma ve Bafl-boyun Kanserli Hastalarda HTLV I-II, HIV ve Anti-HCV Seropozitifli¤inin De¤erlendirilmesi‹nsan T-hücre lenfotropik virüs Tip I (HTLV-I), ço¤unlukla adult T hücreli lösemi-lenfoma olmak üzere bronflioalveolar karsinoma gibi malign hastal›klarla iliflkisi ispatlanm›fl, dünyada yayg›n, ilk insan retrovirüsüdür. Tip II (HTLV-II) patojen oldu¤u tam olarak kan›tlanma-makla birlikte HTLV-I ile genomik olarak homolojisi olan bir retrovirüstür. Hepatit C virüsü (HCV) akut-kronik hepatit, siroz ve karaci¤er kanserinin majör sebebi olan RNA virüsüdür. ‹nsan immün yetmezlik virüsü (HIV syn. HTLV-III), AIDS hastal›¤›n›n etken virüsüdür. Bu virüslerin malign hastal›klar›n oluflumu ve geliflimi ile ilgili çal›flmalar tüm dünyada k›s›tl› olup ülkemizde ise ayr›nt›l› bir çal›flmaya rastlanmam›flt›r. Bu çal›flmada lenfoma ve bafl-boyun karsinomu tan›s› alm›fl hastalarda HTLV I-II, HIV ve HCV virüslerinin varl›¤›n› ve bu virüslerin bu kanserlerle iliflkisi de¤erlendirildi. Sonuç olarak 86 lenfoma hastas›n›n ikisinde ve 80 bafl-boyun kanserli hastan›n da ikisinde HTLV I-II seropozitifli¤i tespit edildi. Bu ve di¤er viral etkenlerin sebep oldu¤u malignitelerde yap›lacak daha bü-yük çal›flmalara ihtiyaç vard›r.