Seroprevalence of herpes simplex virus types 1 and 2 in HIV-Infected and uninfected homosexual men in a primary care setting

Russell, Darren; Tabrizi, Sepehr N.; Russell, Jayne; Garland, Suzanne M.

doi:10.1016/s1386-6532(01)00203-7

Cited by 54 publications

(34 citation statements)

References 23 publications

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“…History of genital herpes was obtained from 21.8% of the HSV-2 positive subjects, which indicates that only a low proportion of the patients were aware of the HSV-2 infection. This finding is in accordance with other reports (Weinberg et al 1993, Russel et al 2001, van Benthem et al 2001, confirming that clinical information greatly underestimates the prevalence of HSV-2 disease and underscores the importance of teaching these patients how to identify the episodes of active genital herpes (Langenberg et al 1989, Weinberg et al 1993) and counseling them to seek health care for genital signs and symptoms. The potential role of HSV-2 infection in facilitating HIV transmission highlights the need for including anti-HSV-2 testing and therapy in the management of HIV positive patients, especially for reducing the risk of transmission of HIV through herpetic lesions (Suligoi et al 2002).…”

Section: Discussionsupporting

confidence: 91%

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Seroepidemiological study of herpes simplex virus type 2 in patients with the acquired immunodeficiency syndrome in the city of Niterói, Rio de Janeiro, Brazil

Santos

Oliveira

Setúbal

et al. 2006

Mem. Inst. Oswaldo Cruz

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This study was designed to determine the seroprevalence of herpes simplex virus type 2 HSV-2 is one of the commonest causes of genital ulceration worldwide, but the relative importance of infection appears to vary from place to place. In countries where co-infection with human immunodeficiency virus (HIV) and HSV-2 is common the significance of HSV-2 as a cause of ulceration has probably been underestimated (Cowan et al. 2003). The ulceration that occurs in immunocompromised individuals is frequently atypical, severe, and persistent (McGrath & Newman 1994, Suligoi et al. 2002 and may mimic ulceration caused by other organisms, such as syphilis and chancroid (Chen et al. 2000).There is increasing evidence that HSV-2 facilitates HIV transmission (Wasserheit 1992 unrecognized and most people who are infected shed virus at some time and are, therefore, potentially infectious. Therefore, seroepidemiological studies are critical to understanding the pattern and distribution of infection within populations (Cowan et al. 2003). Nonetheless, data on the prevalence of HSV-2 infection among HIV-positive individuals are scarce. Recently, commercially available type-specific serologic assays allowed more extensive study of the epidemiology of HSV-2 infections (Ashley et al. 1998, Cowan et al. 2003, Turner et al. 2003.The objectives of the current study were to determine the seroprevalence of HSV-2 and its association with age, sex as well as other demographic and behavioural factors among HIV-positive patients from a large general hospital in Niterói, state of Rio de Janeiro, Brazil. PATIENTS AND METHODS Subjects -The study was conducted in the Hospital Universitario Antonio Pedro, Federal Fluminense University, a large tertiary public hospital located in Niterói, state of Rio de Janeiro, Brazil. Niterói has around 474,000 inhabitants and the hospital provides health care to neighboring municipalities and to a lesser extent to populations from other parts of the state. results and offered treatment, if necessary. Blood samples were assigned a numerical code to conceal the identity of the study subjects. The patients were interviewed using a standardized questionnaire that included information on demographic variables (gender, age, level of education, residence), behaviour practices (number of lifetime sex partners, age of first sexual intercourse), and past history of sexually transmitted diseases (STD) and genital herpes. Serum samples were collected from each participant and linked to the questionnaire by the aforementioned numerical code.Serological tests -Sera were screened for HVS-2 immunoglobulin G antibodies using an indirect HSV-2 enzyme-linked immunosorbent assay (HerpesSelect, Focus Technologies, Cypress, CA, US), which has an estimated sensitivity of 98% and an estimated specificity of 97% (Ashley et al. 1998). The test uses recombinant HSV-2 gG2 antigen to identify HSV-2 antibodies, and was run according to the manufacturer's specifications, with control sera in the same test plate. Results were reported accord...

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Section: Discussionsupporting

confidence: 91%

“…According to Russel et al (2001), the higher rate of HSV-2 seen in HIV-antibody positive subjects may indicate that individuals who are infected by HSV are more likely to acquire HIV infection, and vice-versa.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiological study of herpes simplex virus type 2 in patients with the acquired immunodeficiency syndrome in the city of Niterói, Rio de Janeiro, Brazil

Santos

Oliveira

Setúbal

et al. 2006

Mem. Inst. Oswaldo Cruz

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show abstract

“…History of genital herpes was reported in only 27.33% of HIV-positive individuals indicating that only a low proportion of individuals were aware of HSV-2 infections. These findings were in accordance with findings of Santos FC et al, Russel et al and Van benthem et al [27][28][29] Prompt diagnosis of HSV-2 infection in HIV individuals leads to patients early management, possible initiation of antiretro viral treatment leading to reduced shedding of HSV and HIV in genital secretions. 30 Our study supports the findings of Cowan et al that HSV-2 facilitates HIV transmission and strong measures are required for implementation of HSV control measures and development of vaccines against HSV.…”

Section: Discussionsupporting

confidence: 91%

Seroepidemiological study of Herpes simplex virus 2 in human immuno deficiency virus-positive individuals attending a tertiary care hospital of South India

Singh¹,

Halthur²,

Kandati

et al. 2016

Int J Community Med Public Health

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“…[1][2][3] The impact of HSV-2 infection on HIV acquisition and transmission, as well as the potential effects of HSV-2 on systemic HIV replication have been described. [4][5][6] Any intervention to disrupt the synergy between HIV and HSV-2 is likely to rely on serological identification of HSV-2 infection among HIV infected people.…”

mentioning

confidence: 99%

The psychosocial impact of serological herpes simplex type 2 testing in an urban HIV clinic

Meyer

2005

Sexually Transmitted Infections

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Seroprevalence of herpes simplex virus types 1 and 2 in HIV-Infected and uninfected homosexual men in a primary care setting

Cited by 54 publications

References 23 publications

Seroepidemiological study of herpes simplex virus type 2 in patients with the acquired immunodeficiency syndrome in the city of Niterói, Rio de Janeiro, Brazil

Seroepidemiological study of herpes simplex virus type 2 in patients with the acquired immunodeficiency syndrome in the city of Niterói, Rio de Janeiro, Brazil

Seroepidemiological study of Herpes simplex virus 2 in human immuno deficiency virus-positive individuals attending a tertiary care hospital of South India

The psychosocial impact of serological herpes simplex type 2 testing in an urban HIV clinic

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