Seroprevalence of Hepatitis E Among Hemodialysis Patients: a Report From Hamadan, Iran

Eini, Peyman; Mamani, Mojgan; Javani, Marzieh

doi:10.5812/hepatmon.15(5)2015.26260

Cited by 13 publications

(11 citation statements)

References 13 publications

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“…It may be result from the differences between source of water (26% on non-piping water in Hamedan), while all our study patients were using tap water or more hemodialysis time . (15) The main route of transmission is fecal-oral and blood was not as an important route for transmission because the virus can not cause a chronic carrier state. (16) But studies over the past decade showed the possibility of intravenous passage from person to person like hepatitis B and C virus.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of anti-hepatitis E virus antibody among hemodialysis patients in Gorgan, north of Iran

et al. 2016

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Background and Aims:Hepatitis E virus is a public health concern and about a third of people in the world live in endemic areas. Although HEV is believed to be transmitted by fecal-oral routes between humans in low sanitary conditions, but evidence of transmission have been reported in hemodialysis (HD) patients. Materials and Methods:The aim of present study was to determine the prevalence of anti-HEV antibody among HD patients in Gorgan, north of Iran. In this cross-sectional study, totally 300 HD patients from May to December 2014 were tested for detection of anti-HEV IgG and IgM by commercial HEV enzyme-linked immunosorbent assay (ELISA) kit. Demographic variables were collected in pre-designed questionnaires. Results: Out of 300 individuals, 148 (49.3%) were male and 152 (50.7%) were female. The overall anti-HEV IgG seroprevalence rate was 4%. Result showed significant association between anti-HEV IgG and duration of dialysis (p = 0.03), but there were no significant differences between the subjects grouped according to gender, Ethnicity, dialysis per week and age. No anti-HEV IgM were detected in patients. Conclusions: Since our finding showed statically significant relationship between duration of hemodialysis and anti-HEV. Therefore, hemodialysis maybe be considered as a risk factor in HEV transmission. However further studies are needed to confirm our data.

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Section: Discussionmentioning

confidence: 99%

“…In this study, none of the variable were not associated with increased risk of HEV-antibody positive similar to some previous studies in Iran. (15,30)…”

Section: Discussionmentioning

confidence: 99%

Evaluation of anti-hepatitis E virus antibody among hemodialysis patients in Gorgan, north of Iran

et al. 2016

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“…Available data, including our present results, on factors associated with anti -HEV IgG in HD patients, sex, older age, and HD duration, are inconsistent. [30][31][32][33][34] According to Mitsui et al, 30 89.7% of HD patients are HEV -infected before the HD initiation. They suggested that anti -HEV IgG positivity may persist in HD patients for years as in the general population.…”

Section: Correlates Of Anti-hepatitis E Virus Immunoglobulin Gmentioning

confidence: 99%

“…Anti -HEV IgG positivity did not correlate with a history of renal transplantation in our HD subjects, similarly as demonstrated by Psichogiou et al 31 The proportions of patients with HBV/HCV infections were comparable between HEV seropositive and seronegative HD groups, what is in concordance with the previous studies. [30][31][32][33]36 Transmission of HEV with the blood seems to be of less importance in HD patients in the era of standard administration of erythropoietin stimulating agents.…”

Section: Correlates Of Anti-hepatitis E Virus Immunoglobulin Gmentioning

confidence: 99%

IFN-λ4 gene polymorphisms, circulating IFN-λ3, and clinical variables in hemodialysis patients exposed to hepatitis E virus

Grzegorzewska¹,

Świderska²,

Niepolski³

et al. 2018

Polish Archives of Internal Medicine

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Introduction Factors associated with hepatitis E virus (HEV) infection are rarely recognized in patients on renal replacement therapy (RRT), and the results of studies are inconsistent. Objectives We aimed to search for determinants of HEV seroprevalence among polymorphisms of the interferon‑λ4 gene (IFNL4) associated with seroclearance of hepatotropic viruses (IFNL4 rs12979860, rs8099917 near IFNL4), circulating interferon λ3 (IFN‑λ3), and clinical variables of patients treated with hemodialysis (HD) in a HEV‑endemic region. Patients and methods The study was carried out in 90 HD patients. HEV open reading frame 2 antigen (HEV Ag), immunoglobulin M and G antibodies to HEV (anti‑HEV IgM and anti‑HEV IgG, respectively) and IFN‑λ3 were tested, and IFNL4 polymorphic variants (rs8099917, rs12979860) were genotyped. Survival analysis was conducted concerning anti‑HEV IgG positivity. Results In the study group, there were 37.8% anti‑HEV IgG‑positive subjects. None was HEV Ag or anti‑HEV IgM positive. HD modalities utilizing high‑flux dialyzers (adjusted odds ratio [OR], 3.586; 95% confidence interval [CI], 1.142-11.263; P = 0.03) as well as major homozygosity in rs8099917 (adjusted OR, 4.933; 95% CI, 1.516-16.054; P = 0.008) and rs12979860 (adjusted OR, 3.537; 95% CI, 1.136-11.014, P = 0.03), but not circulating IFN‑λ3 levels, were positive determinants of anti‑HEV IgG positivity. Liver enzyme activities and C‑reactive protein levels tested as response variables to HEV exposure, as well as survival probability, were not different between patients stratified by anti‑HEV IgG positivity. Conclusions Among HD patients, IFNL4 polymorphisms and treatment with high‑flux HD are explanatory variables for isolated anti‑HEV IgG positivity indicating spontaneous HEV resolution.

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“…However, independent reports showed that HEV transmission may also occur through blood transfusion [10] and from patient-to-patient through nosocomial transmission [11]. In this context, several studies reported a high prevalence of anti-HEV antibodies among hemodialysis (HD) patients suggesting that this population represents a highrisk group for this viral infection [12,13]. Nevertheless, others suggested that chronic HD is not associated with an increased risk of exposure to this virus [14,15].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of anti-hepatitis E virus IgG antibodies in sera from hemodialysis patients in Tripoli, Lebanon

et al. 2020

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Hepatitis E virus (HEV) is an important global public health concern. Several studies reported a higher HEV prevalence in patients undergoing regular hemodialysis (HD). In Lebanon, the epidemiology of HEV among HD patients has never been investigated previously. In this study, we examine the seroprevalence of HEV infection among 171 HD patients recruited from three hospital dialysis units in Tripoli, North Lebanon. Prevalence of anti-HEV IgG antibodies was evaluated in participant's sera using a commercial enzyme-linked immunosorbent assay (ELISA). The association of socio-demographic and clinical parameters with HEV infection in patients was also evaluated. Overall, 96 women and 75 men were enrolled in this study. Anti-HEV IgG antibodies were found positive in 37/171 HD patients showing a positivity rate of 21.63%. Among all examined variables, only the age of patients was significantly associated with seropositivity (P = 0.001). This first epidemiological study reveals a high seroprevalence of HEV infection among Lebanese HD patients. However, further evaluations that enroll larger samples and include control groups are required to identify exact causative factors of the important seropositivity rate in this population.

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Seroprevalence of Hepatitis E Among Hemodialysis Patients: a Report From Hamadan, Iran

Cited by 13 publications

References 13 publications

Evaluation of anti-hepatitis E virus antibody among hemodialysis patients in Gorgan, north of Iran

Evaluation of anti-hepatitis E virus antibody among hemodialysis patients in Gorgan, north of Iran

IFN-λ4 gene polymorphisms, circulating IFN-λ3, and clinical variables in hemodialysis patients exposed to hepatitis E virus

Prevalence of anti-hepatitis E virus IgG antibodies in sera from hemodialysis patients in Tripoli, Lebanon

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