Seroprevalence of hepatitis C virus: the first population-based study from Iran

Merat, Shahin; Rezvan, H; Nouraie, Mehdi; Jafari, Elham; Abolghasemi, Hassan; Radmard, Amir Reza; Zaer-Rezaii, Hanieh; Amini-Kafiabad, Sedigheh; Maghsudlu, Mahtab; Pourshams, Akram; Malekzadeh, Reza; Esmaili, Saeed

doi:10.1016/j.ijid.2009.11.032

Cited by 102 publications

(98 citation statements)

References 17 publications

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“…The highest HCV infection rate in Iranian general population was reported by a study conducted in Hormozgan province (11). This high prevalence could be explained by the fact that Hormozgan province is located in the northern littoral of Persian Gulf and much of the economy of this province is dependent on frequent travelling to the Arab countries located in the south cost of Persian Gulf.…”

Section: Discussionmentioning

confidence: 96%

Update on the Prevalence of Hepatitis C Virus Infection Among Iranian General Population: A Systematic Review and Meta-Analysis

et al. 2017

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Section: Discussionmentioning

confidence: 96%

Update on the Prevalence of Hepatitis C Virus Infection Among Iranian General Population: A Systematic Review and Meta-Analysis

et al. 2017

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“…One important thing in the mentioned data is that 7 cases means 3.9% of total patients, 5 cases of Health staffs and 2 hemophilia cases, are infected due to fault in Health systems because frequency of HCV infection in normal population is 0.5-1% (Merat et al, 2010). This is an unfortunate report that could be a catastrophe for a Health system.…”

Section: Resultsmentioning

confidence: 99%

Hepatitis C Virus Genotype Distribution in Kermanshah Province, Western Iran

Hatami-Moghadam¹,

Alibakhshi²,

Sayyad³

2016

MAS

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Six major hepatitis C virus genotypes have been characterized, which vary in their geographical distribution. Knowledge of the distribution of various genotypes is essential for successful future research, treatment and control strategies. In this study, the distribution of HCV genotypes and their association with possible risk factors in a group of HCV infected patients from Kermanshah province of Iran was investigated. HCV viral load test by Real time-PCR method was used for diagnosis of infected cases. The genotypes of cases were revealed using Nested-and Multiplex-PCR and with direct sequencing results were confirmed. Risk factors were also recorded and a multivariate analysis was performed. Among 180 infected people, 138 (76.6%) with 3a genotype, 35 (19.4%) with 1a genotype, 3 (1.7%) with 1b genotype and 4 (2.2%) with 3a and 1b were determined. HCV was transmitted by different routes such as intravenous drug abuse (IVDA), tattooing, sexual, blood transfusion and other risk factors. IVDA and sex are the main risk factors in the men and women, respectively. However, 3a is the predominant genotype in the all groups. This study revealed that 3a is the most prevalent genotypes in Kermanshah province.

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“…Study of Ataei et al in Iran, reported the prevalence of HCV as 8% among 466 patients with thalassemia major [54], which is similar to our findings. In 2010, a study reported the seroprevalence rate of 0.5% among healthy Iranian blood donors [35]. Genotype 1a is most commonly found in Northern Europe and North America [55,56].…”

Section: Prevalence Of Hcv Among Thalassemia Patientsmentioning

confidence: 99%

Molecular Epidemiology of Hepatitis C Virus Genotypes in Patients with Thalassemia Major in Golestan Province, Iran

Zhand¹,

Bazuori²,

Tabarraei³

et al. 2017

jcbr

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Introduction: In Iran, hepatitis C virus (HCV) is the most prevalent cause of chronic hepatitis and cirrhosis in patients with hemophilia, thalassemia, and renal failure. Recent studies suggest that patients infected with different HCV genotypes have different clinical profiles, severity of liver disease and response to therapy. Several molecular methods targeting different HCV genomic regions have been introduced for genotyping. Direct sequencing of amplified PCR products is the gold standard method, followed by phylogenetic analysis of clinical material. The aim of this study was to determine genotypes of HCV-infected patients with thalassemia in Golestan Province, Iran. Materials and Methods: This cross-sectional study included 217 patients (mean age: 21.82 ± 16 years, 50.7% male) with thalassemia major. Enzyme-linked immunosorbent assay (ELISA) was used for detection of HCV antibodies. Positive HCV-Ab samples were confirmed by reverse transcription polymerase chain reaction (RT-PCR) and sequencing. HCV genotypes were determined by aligning nucleotide sequences of patients with the standard nucleotide sequences obtained from GenBank (accession number: AB520610). Results: Of 217 patients with thalassemia major, 14 (6.45%) were found as anti-HCV-positive in the ELISA test. Among them, two patients (14.28%) had positive RT-PCR results. In addition, all patients were infected with HCV genotype 1a. Conclusions: Genotype 1a is the predominant HCV genotype in patients with thalassemia major in the Golestan province, Iran.

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Seroprevalence of hepatitis C virus: the first population-based study from Iran

Abstract: We found the prevalence of HCV infection in Iran to be higher than previous estimates. It appears that the rate is rising, and in the future, hepatitis C will replace hepatitis B as the most common cause of chronic viral liver disease in Iran.

Cited by 102 publications

References 17 publications

Update on the Prevalence of Hepatitis C Virus Infection Among Iranian General Population: A Systematic Review and Meta-Analysis

Update on the Prevalence of Hepatitis C Virus Infection Among Iranian General Population: A Systematic Review and Meta-Analysis

Hepatitis C Virus Genotype Distribution in Kermanshah Province, Western Iran

Molecular Epidemiology of Hepatitis C Virus Genotypes in Patients with Thalassemia Major in Golestan Province, Iran

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