Seroprevalence of Hepatitis C Virus in Thalassemic Patients

Uddin, Nesar; Rana, Meena; Islam, M A; Begum, Ferdousi; Salimullah, Asm; Ahsan, Kamrul; Sarker, MN; Ahmed, Dewan Saifuddin; Roy, Prasun Kumar; Raihan, Asma

doi:10.3329/jdmc.v18i2.6269

Cited by 3 publications

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“…In this study, we found that older age of the patients, longer duration of the disease in years, elevated liver enzymes (U/L), and increasing ferritin level (ng/mL) are associated with higher seroprevalence of TTIs. Similar findings were reported by other studies [ 37 – 39 ]. Though the standardized blood screening procedures were outlined in the 1990s for blood-related products and were subsequently implemented in various countries, higher prevalence of TTIs, especially HCV, among thalassemic patients requires greater attention from a public health perspective.…”

Section: Discussionsupporting

confidence: 93%

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt

Mahmoud

El-Mazary

Khodeary

2016

Advances in Hematology

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Background. Frequent blood transfusions in thalassemia major children expose them to the risk of transfusion-transmitted infections (TTIs). The aim of this study was to estimate the prevalence of hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and cytomegalovirus (CMV) in thalassemic children attending the Pediatrics Departments of both Sohag and Minia Universities of Upper Egypt, during the period from May 2014 to May 2015. Methods. Serum samples were screened for hepatitis B surface antigen (HBsAg), anti-HCV, anti-CMV, and anti-HIV type 1 and type 2 using the Vitek Immunodiagnostic Assay System. Results. The frequencies of anti-HCV, HBsAg, anti-CMV, and anti-HIV type 1 and type 2 were found to be 37.11%, 4.12%, 4.12%, 0.00%, and 0.00%, respectively. Seropositivity for anti-HCV, HBsAg, and anti-CMV increased with increasing age of the patients, duration of the disease, serum ferritin level (ng/mL), and liver enzymes (U/L), while it was not significantly associated with gender, frequency of blood transfusion, or the status of splenectomy operation (P > 0.05). Conclusion. The frequency of TTIs, especially HCV, is considerably high among Egyptian children with thalassemia major. It is therefore important to implement measures to improve blood transfusion screening, such as polymerase chain reaction, in order to reduce TTIs from blood donor units.

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Section: Discussionsupporting

confidence: 93%

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt

Mahmoud

El-Mazary

Khodeary

2016

Advances in Hematology

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“…Both the HBV and HCV cause liver damage. They lead to chronic liver disease, cirrhosis, hepatocellular carcinoma (HCC), end stage liver disease and death and are the most common transfusion transmitted infections (5,(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Identification of HBV and HCV transmission in multi-transfused Thalassemia patients of Azad Jammu and Kashmir, Pakistan

Mahmood¹,

Aslam²,

Zaman

et al. 2022

Preprint

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Background: Thalassemia patients need regular blood transfusion which saves their lives but increases the risk of acquiring viral infections like hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Objective(s): This study aimed to screen out the HCV and HBV infections in Thalassemia patients receiving regular blood in three centers of Azad Jammu and Kashmir (AJK), Pakistan. Materials and Methods: It was a cross sectional, multicenter study involving 224 Thalassemia patients. The study was carried out from August 2019 to January 2020 in Thalassemia centers of Sheikh Khalifa Bin Zaid hospital Rawalakot, District Headquarters hospital (DHQ) Palandari, and Combined Military Hospital (CMH) Muzaffarabad, AJK. A total of 224 patients were screened out for HCV and HBV. Indirect ELISA was carried out to detect anti HCV antibodies while direct ELISA was carried out to detect the HBsAg from all the samples using commercially available ELISA kits. Results: Overall, 12 patients (5.36%) were found to be positive for HBV while 63 (28.1%) were positive for HCV. HBV positive patients included 7 (5.69%) males and 5 (4.95%) females while HCV positive patients included 26 (41.27%) males and 37 (58.73%) female patients. Both the viruses were more common among elder patients as compared to younger patients. Conclusion: Prevalence of HCV is very high and that of HBV is moderately high among Thalassemia patients of AJK.

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Prevalence of hepatitis C virus infection among thalassemia patients: a perspective from a multi-ethnic population of Pakistan

Din

Malik

Ali

et al. 2014

Asian Pacific Journal of Tropical Medicine

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Seroprevalence of Hepatitis C Virus in Thalassemic Patients

Cited by 3 publications

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Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt

Identification of HBV and HCV transmission in multi-transfused Thalassemia patients of Azad Jammu and Kashmir, Pakistan

Prevalence of hepatitis C virus infection among thalassemia patients: a perspective from a multi-ethnic population of Pakistan

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