Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program

Hu, Yang; Yeh, Chih Ching; Chen, Ruey Yu; Su, Chien Tien; Wang, Wen Chang; Bai, Chyi Huey; Chan, Chi Fei; Su, Fu Hsiung

doi:10.7717/peerj.4297

Cited by 51 publications

(45 citation statements)

References 31 publications

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“…The chronic HBV carrier rate among the general Taiwanese population ranged from 15% to 20% prior to the introduction of the national HBV vaccination program in 1984 [7]. The nationwide HBV vaccination campaign program has successfully reduced the prevalence rate of chronic HBV to <1.0% in people born after 1992 [8].…”

Section: Introductionmentioning

confidence: 99%

Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

Muo

et al. 2020

Viruses

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Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20–1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55–64, and 65–74 years were 1.63 (95% CI = 1.48–1.79), 1.24 (95% CI = 1.13–1.37), and 1.02 (95% = 0.92–1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial.

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Section: Introductionmentioning

confidence: 99%

Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

Muo

et al. 2020

Viruses

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“…Universal vaccination programs significantly decreased the HBV infection rate among all age groups born since the program was initiated. The effectiveness of the vaccination program has been demonstrated in various studies that have reported a decrease in the HBsAg carrier rate, incidence of chronic HBV infection, and rates of mother-to-child transmission [36][37][38] . A study assessing the long-term efficacy of HBV vaccination based on seroprevalence and an age-period-cohort model of HBV seromarkers in Taiwan showed that the HBsAg positivity rate among university students decreased from 9.7% among those born before June 1974 to <1.0% in those born after 1992 [38] .…”

Section: Discussionmentioning

confidence: 99%

HBsAg, Anti-HCV and Anti-HIV Seroprevalence Among Patients Admitted to State Hospital between 2014 and 2018

Bilman¹

2019

mjima

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The epidemiology of viral hepatitis and human immunodeficiency virus (HIV) infections has been changing worldwide and in Turkey. The aim of this study was to present current information about seropositivity rates in hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (HCV), and anti-HIV test results according to gender, age, and other risk factors (dialysis, preoperative tests, outpatient clinics) in patients aged 1-99 who presented to the İzmir Menemen State Hospital between January 2014 and July 2018. Materials and Methods: During the study period, 58,752 samples were tested for HBsAg, 53,649 samples for anti-HCV, and 48,162 samples for anti-HIV by chemiluminescence immunoassay method by using HBsAg 2, anti-HCV 2 and HIV combi PT kits in a Roche Modular E170 device (Roche Diagnostics GmbH, Penzberg, Germany). Data were collected retrospectively from the microbiology laboratory database. Results: The seropositivity rates for HBsAg, anti-HCV, and anti-HIV were 4.75% (2790/58,752), 0.7% (376/53,649), and 0.02% (11/48,162), respectively. The mean age of patients with HCV seropositivity was significantly higher (57±10 years) than patients with hepatitis B virus (HBV) seropositivity (41±13 years). Hepatitis B surface antigen and anti-HCV seropositivity rates were significantly higher in dialysis patients (8.7% and 10%, respectively) than in the other groups. Of the HBsAg-positive individuals, 74 (2.65%) were born between 1999 and 2007 (HBV vaccine was added to the routine vaccination program in Turkey in 1998) and only 1 (0.03%) was born after 2007 (the year that family medicine practice was implemented in İzmir province). The other 2,715 HBsAg-positive individuals (97.32%) were born in or before 1998. Conclusion: The seropositivity rates for HBsAg and anti-HCV in our region were found to be compatible with other regions. Monitoring changes in regional data and surveillance studies are important for HBV, HCV, and HIV infections and seropositivity rates.

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“…U ovome se ogleda značaj vakcine ne samo u sprečavanju akutnih infekcija već i u prevenciji hroniciteta. Imunizacija protiv HBV infekcije, sprovedena na Tajvanu, pokazuje pad stope hronične infekcije 30 godina nakon početka imunizacije (8). Jedan od problema su i nevakcinisani medicinski radnici koji su u povećanom riziku za infekciju usled profesionalne izloženosti.…”

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Epidemiological characteristics of acute HBV infection

Perić¹,

Bojović²

2019

Medicinski podmladak

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Introduction: Despite the existing vaccines and mandatory immunization, the number of patients with acute HBV infection is substantial. According to some authors, almost 30% of world population has a serological confirmation of acute HBV infection or has recovered from it. Aim: The aim of this study was to show the most common clinical course of acute HBV infection. Our goal was also to evaluate risky forms of behaviour that would most likely lead to infection and which age groups are the most vulnerable. Material and methods: The study has been conducted based on the medical charts and case records of 243 patients hospitalised at the Clinic for Infective and Tropical Diseases in Belgrade and diagnosed with acute hepatitis B infection. Selected demographic characteristics were analyzed: sex, age, occupation, vaccination status and risk factors. Transaminase activity (ALT, AST) was spectrophotometrically measured; PV was determined by using photo-optic coagulometry, while ELISA was used to get the serological parameters (HBsAg, anti-HBc IgM, anti-HBs antibodies). Results: Results have shown that acute HBV occurs more often in the age group between 21 and 40. Infection occurs more often among men (72%). Only 24% of the participants in the study mentions sexual contact as risk. At the moment of their admission, the values of transaminases were mostly increased > 20 x, compared to standard values. Most patients recovered (negative HBsAg among 72%), but anti-HBs antibodies were developed only among 18%. There was no statistically significant difference between patients who were on the casual therapy and those symptomatically treated. Conclusion: Awareness of the HBV infection, the way it is transmitted and the importance of regular checkups is not high enough among already infected people. The future of prevention of the HBV infection lies in the immunization and education of the population about this infection.

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Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program

Cited by 51 publications

References 31 publications

Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

HBsAg, Anti-HCV and Anti-HIV Seroprevalence Among Patients Admitted to State Hospital between 2014 and 2018

Epidemiological characteristics of acute HBV infection

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