Seroprevalence of hepatitis B surface antigen and its correlation with risk factors among new recruits in Turkey

Altay, Tulin; Uşkun, Ersin; Akçam, Füsun Zeynep

doi:10.1016/j.bjid.2012.06.003

Cited by 13 publications

(15 citation statements)

References 10 publications

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“…anti-HBs (31.9%) seroprevalence fall within the ranges provided for countries with an intermediate endemic profile (4,20) and in agreement with past studies on epidemiology of hepatitis in Turkey which indicated an overall prevalence of chronic HBV infection of 4-10 % (3.5% in the western and 7% in the eastern regions), and of anti-HBs positivity of 20.6-52.3% [7,10,14,15,19,21,22]. This regional difference in HBV positivity, not observed in HCV infection, re-emphasizes the role of close contact and intrafamilial transmission in areas with crowded families and poor hygienic conditions in HBV seroprevalence.…”

Section: Discussionsupporting

confidence: 89%

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Tözün

Özdoğan

Çakalǒglu

et al. 2015

Clinical Microbiology and Infection

230

147

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The present study was designed to determine the seroprevalence of hepatitis B and C virus (HBV, HCV) infections and risk factors in the Turkish general population. Participants were enrolled from urban and rural areas of the predetermined 23 EUROSTAT NUTS 2 region. A two-stage stratified sampling method was used to select participants from these regions (n = 5460; 50.9% females; mean (SD) age: 40.8 (14.7) years). Sociodemographics, clinical characteristics and risk factors were recorded at home visits. The seropositivity rates for hepatitis B surface antigen (HBsAg), anti-HCV, anti-HBs and anti-HBc total were 4.0%, 1.0%, 31.9% and 30.6%, respectively. Among HBsAg-positive cases, 94.5% were anti-HBe-positive, 70.2% were HBV-DNA-positive and 2.8% were anti-HDV total positive; 99.1% of HBV infections were of genotype D. Close contact with a hepatitis patient (OR 3.24; 95% CI 2.25-4.66; p < 0.001), living in the southeastern region (OR 2.74; 95% CI 1.7-4.45; p < 0.001), male gender (OR 1.77; 95% CI 1.28-2.46; p < 0.001), being married (OR 1.62; 95% CI 1.02-2.57; p 0.038), educational level less than high school (OR 1.53; 95% CI 1.04-2.26; p 0.03), orodental interventions (OR 1.54; 95% CI 1.01-2.35; p 0.047) and a history of non-disposable syringe use (OR 1.4; 95% CI 1.01-1.96; p 0.045) were significant determinants of HBsAg positivity. Age ≥50 years (OR 2; 95% CI 1.09-4.3; p 0.026) was the only significant predictor of anti-HCV positivity. In conclusion, our findings revealed an HBsAg positivity in 4% and anti-HCV positivity in 1% of the adult population and at least one-third of the population has been exposed to HBV infection in Turkey.

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Section: Discussionsupporting

confidence: 89%

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Tözün

Özdoğan

Çakalǒglu

et al. 2015

Clinical Microbiology and Infection

230

147

View full text Add to dashboard Cite

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“…In Turkey, hepatitis B vaccine was included in the national vaccination program in 1998. While the vaccine is given to any adult in the risk groups who desires protection, all infants are vaccinated with three doses (14,15).…”

Section: Discussionmentioning

confidence: 99%

Frequency of Hepatitis B Virus, Hepatitis C Virus and HIV Infections in Cannabis and Opioid Addicts

Karabulut¹,

Çatak²

2017

vhd

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ÖZObjective: There are very few data about the epidemiology of hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV infections in drug addicts in Turkey, whereas several countries have a developed surveillance systems to monitor the spread of HBV, HCV and HIV infections in drug users. In this study, HBV, HCV and HIV prevalence in cannabis and opioid addicts were investigated. Materials and Methods: Hepatitis B surface antigen (HBsAg), antiHBs, anti-HCV and anti-HIV tests were analyzed by enzyme-linked immunosorbent assay. The cannabis and opioid metabolites in urine samples of drug addicts were analyzed by cloned enzyme donor immunoassay.Results: This retrospective study was conducted on 276 individuals with a mean age of 28.89±10.49 years. HBsAg, anti-HBs and anti-HCV prevalence in drug addicts was found to be 4%, 52.3% and 7.9%, respectively. In all the drug addicts, anti-HIV test was negative. Whereas the rate of HBsAg among cannabis users (8.8%) was higher than opioid (4.1%) and both cannabis and opioid users (1.4%), the difference was not statistically significant. Although anti-HCV positivity among cannabis users was not detected, 6.4% of opioid users and 15.9% of both cannabis and opioid users were anti-HCV positive (p=0.009). Conclusion:This study showed that HCV infection among especially opioid users and both cannabis and opioid users was a problem. Understanding of local status in HBV, HCV and HIV infections is crucial for developing prevention and geographical strategies for these infections.

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“…In Turkey, hepatitis B vaccination was included in the national immunization program in 1998, and infants have been vaccinated with three doses. Adults in the risk groups are also vaccinated at their request (16,17).…”

Section: Discussionmentioning

confidence: 99%

The Frequency of Hepatitis B Virus, Hepatitis C Virus and Human Immunodeficiency Virus Infections among Patients with Schizophrenia in a Mental Health Hospital in Turkey

Karabulut¹

2016

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ÖZObjective: Several studies have demonstrated that psychiatric patients are at increased risk for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections compared the general population. The aim of this study was to determine the frequency of HBV, HCV and HIV infections among patients with schizophrenia in Elazığ Mental Health Hospital in Turkey. Materials and Methods: Screening tests for HBV, HCV and HIV have been routinely performed in patients with schizophrenia. Hepatitis B surface antigen (HBsAg), anti-hepatitis B surface (anti-HBs), anti-HCV and anti-HIV tests were performed by the ELISA technique. Results: Four hundred and eighty-nine patients with schizophrenia in the mental health hospital were screened for HBsAg, anti-HBs, anti-HCV and anti-HIV. The study population was consisted of 409 male and 80 female patients. Overall seroprevalence was detected as 6.5% for HBsAg, 41.5% for anti-HBs and 0.2% for anti-HCV. All patients were found to be anti-HIV-negative. Conclusion:This study showed that the frequency of HBV, HCV and HIV infections among patients with schizophrenia was no higher than in the general population. Screening for blood-borne pathogens at the time of admission to the hospital is an important strategy to identify infected residents. Furthermore, hepatitis B vaccination schedule should be extended to include all the community. Sonuç: Bu çalışma, şizofreni hastalarında HBV, HCV and HİV enfeksiyon sıklığının genel popülasyondan daha yüksek olmadığını göstermiştir. Hastaneye başvuru sırasında kan yoluyla bulaşan patojenler için tarama yapılması, enfekte bireyleri belirlemek için önemli bir stratejidir. Ayrıca, hepatit B aşılama programı tüm toplumu kapsayacak şekilde genişletilmelidir.

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Seroprevalence of hepatitis B surface antigen and its correlation with risk factors among new recruits in Turkey

Abstract: The HBsAg seropositivity found in this study supports the fact that Turkey remains in the medium endemicity zone, and that horizontal transmission is predominant.

Cited by 13 publications

References 10 publications

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Frequency of Hepatitis B Virus, Hepatitis C Virus and HIV Infections in Cannabis and Opioid Addicts

The Frequency of Hepatitis B Virus, Hepatitis C Virus and Human Immunodeficiency Virus Infections among Patients with Schizophrenia in a Mental Health Hospital in Turkey

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