Seroprevalence of hepatitis B surface antigenemia and its effects on hematological parameters in pregnant women in Osogbo, Nigeria

Kolawole, Olatunji Matthew; Wahab, Abdul; Adekanle, Daniel Adebode; Sibanda, Timothy; Okoh, Anthony I.

doi:10.1186/1743-422x-9-317

Cited by 52 publications

(57 citation statements)

References 19 publications

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“…In another study carried out in Nigeria with 16.5% infection prevalence among pregnant women, the highest infection rate was observed in 30 -34 year-old age group (23.3%) and no significant association was found between infection and age, educational level and job. However, it was significantly associated with history of hepatitis B vaccination (53).…”

Section: Discussionmentioning

confidence: 72%

Prevalence of Hepatitis B Virus infection among Pregnant Women in Iran: A Systematic Review and Meta-analysis

et al. 2016

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Background: Hepatitis B infection can be transmitted both vertically and horizontally. Although the universal neonatal vaccination and catch up vaccination of teenagers along with targeted vaccination of at risk population have decreased the prevalence of HBV infection in Iran dramatically, there is still risk of vertical transmission with subsequent chronic liver disease and hepatocellular carcinoma. This study aims to estimate the prevalence of latent HBV infection among Iranian pregnant women using metaanalysis method.Data Sources: Papers written in Persian or English were identified during a comprehensive search within five national and four international main databases. Study Eligibility Criteria and Participants:Studies reported the HBV infection prevalence among Iranian pregnant women and provided enough quality scores were selected for this meta-analysis. Methods:After a systematic review of national and international databases, duplicated and irrelevant studies were excluded. Standard error of the infection prevalence was calculated based on the binomial distribution. Because of the significant heterogeneity observed among the results, random effects model was applied to combine the results of the primary studies. Moreover, sensitivity analysis and meta-regression models were used to detect the sources of this heterogeneity.Results: At final step of the systematic search, 18 papers entered into the meta-analysis investigating 24853 pregnant women. Prevalence of HBV infection among Iranian pregnant women was estimated as 1.2% (95% confidence interval: 0.9 -1.6). Among different risk factors assessed, only familial history in four studies out of five relevant evidences was statistically significant. Conclusions:HBV infection prevalence among Iranian pregnant women is low and familial history is its major determinant.

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Section: Discussionmentioning

confidence: 72%

Prevalence of Hepatitis B Virus infection among Pregnant Women in Iran: A Systematic Review and Meta-analysis

et al. 2016

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“…Similar sero-prevalence of 6.67% and 6.5% have been reported by Pennap et al [31] in Keffi and Adagbara et al [32] in Minna all in north central and North western Nigeria. While HBV prevalence appear to decrease among pregnant women in the North central states where HIV prevalence is persistently reported to be high [33], HBV prevalence of 11.5%, 12.5%, 16.5% and 6.08% have been reported by Okonko and Udeze [34] in Oluyoro, Ibadan, Ugbebor et al [35] in Benin, Kolawole et al [36] in Oshogbo and Rabiu et al [37] in Lagos, respectively, in south western Nigeria. Almost all pregnant women identified at antenatal clinic in North central states are enrolled for highly active retroviral therapy (HAART) that is known to be therapeutically potent on both HIV and HBV.…”

Section: E M Mbaawuaga Et Almentioning

confidence: 99%

Hepatitis B Virus (HBV) Serological Patterns in Benue State, Nigeria

Mbaawuaga¹,

Iroegbu²,

Ike³

2014

OJMM

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A total of 1535 randomly collected blood specimens from different groups of consenting subjects in Benue State, were screened by ELISA for Hepatitis B surface antigen (HBsAg), hepatitis B surface antibodies (HBsAb), hepatitis B core antibodies (HBcAb), hepatitis Be antigen (HBeAg) and Hepatitis B core IgM antibodies (HBcIgM). The pattern of occurrence of these HBV markers in each blood sample was used to determine individuals with current, acute or chronic infection histories. Of the 1535 sampled individuals, 1319 (85.9%) showed a serological evidence of exposure to HBV infection, some through natural infection (22.7%) and others (13.0%) through vaccination; 12% of the exposed were inferred to be currently infected and 91.2% chronically infected. Hepatitis delta virus (HDV) antigen was also detected in 2.7% of the HBsAg positive individuals; and was encountered more (6.7%) in those with acute hepatitis than those with chronic disease. Thus, there are apparently healthy persons with acute and chronic HBV and HDV infection who may serve as source of infection to others. This calls for a government organized Hepatitis Programme to treat cases of acute and chronic hepatitis and roll out strategy for preventing the spread of HBV infections.

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“…[3,4] In countries where HBV is highly endemic (hepatitis B surface antigen (HBsAg) prevalence rate of 8% or higher), most infections occur during infancy and early childhood. [4,18] Therefore, this study was conducted to determine the seroprevalence of HBV/HIV coinfections among intending blood donors in Port Harcourt, Rivers State, Nigeria.…”

Section: Introductionmentioning

confidence: 99%

HBV and HIV Coinfections among Intending Blood Donors in Port Harcourt, Nigeria

Okonko

Horsefall

Okerentugba

et al. 2014

Journal of Immunoassay and Immunochemistry

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HBV is a major public health concern as it afflicts an estimated 350 million people worldwide. Studies are crucial and necessary to give us a better understanding of the epidemiology of the diseases in developing countries. A clearer picture of HBV/HIV prevalence in Africa is important in order to better educate the population and control these epidemics. This study estimated the seroprevalence of HBV/HIV coinfections among intending blood donors in Port Harcourt, Nigeria. In this cohort study, we collected blood samples from 178 intending blood donors who were confirmed to be HIV-seropositive at the University of Port Harcourt Teaching Hospital (UPTH) from September 2012 to June 2013. Commercial ELISA was used to assay for the presence of HBsAg among these subjects. The overall prevalence was found to be 6.7%. Sex and education (P < 0.05) were the main correlates in this study. Age was not statistically correlated (P > 0.05) in this study. We also observed a high overall HBV/HIV co-infection seronegativity of 93.3% among these blood donors. Group-specific seronegativity was also high ranging from 86.4-100.0%. Although the age groups (13-20, 21-35, and 36-66 years) insignificantly differed, none of their variables showed statistical association with the seronegativity. Our findings underscore the importance of screening for HBV/HIV among blood donors in developing countries, and particularly in sub-Saharan Africa, where the epidemics are still growing and a major public health concern.

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Seroprevalence of hepatitis B surface antigenemia and its effects on hematological parameters in pregnant women in Osogbo, Nigeria

Cited by 52 publications

References 19 publications

Prevalence of Hepatitis B Virus infection among Pregnant Women in Iran: A Systematic Review and Meta-analysis

Prevalence of Hepatitis B Virus infection among Pregnant Women in Iran: A Systematic Review and Meta-analysis

Hepatitis B Virus (HBV) Serological Patterns in Benue State, Nigeria

HBV and HIV Coinfections among Intending Blood Donors in Port Harcourt, Nigeria

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