Seroprevalence of Hepatitis B surface antigen (HBSAG) among pregnant women in Aboh Mbaise local government area of Imo State, Nigeria

Onwuliri, Edith A.; Amona, G; Onwuliri, F. C.; Ndako, James A.

doi:10.4314/ijonas.v4i4.49901

Cited by 2 publications

(3 citation statements)

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“…The number of male participants was slightly higher but not significantly different. In contrast to this study, previous studies (16,17) found that females with detectable Hepatitis B viral load in blood donors were more. Also, it was in contrast with study by Okwuraiwe and his colleagues.…”

Section: Discussioncontrasting

confidence: 99%

Hepatitis B DNA quantification in the serum of hepatitis B surface antigen-positive patients in Benghazi

Abdeldaim,

Abdraba,

Qowaider

et al. 2022

sjuob

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Background: Hepatitis B virus (HBV) infection is a global public health problem, with about 240 million people affected worldwide. Serologic techniques are typically used to diagnose it. However, the decision as to which patient to treat or not remains challenging due to the poor sensitivity of serologic markers as prognostic or severity markers. Viral load (VL) determination using polymerase chain reaction techniques is a useful tool in decision-making. Aim: The aim of this study was to determine the pattern of HBV viral load levels in people of different age and sex groups, to predict the risk of hepatocellular carcinoma and liver cirrhosis in HBsAg positive patients in the east of Libya. Materials and Methods: This is a retrospective and descriptive study. Only one HBV VL test carried out on patients attending the Benghazi university center (from east of Libya) for specialized medical services prior to any HBV targeted therapy were included in the study over a period of 40 months (January 2014 to April 2018) . Hepatitis B DNA VL determinations were analyzed using Microsoft Excel 2010 and Minitab version 17. Results: A total of 431 patients, of whom 51.3% (210) were males and 48.7% (221) were females, were included in the study. Of the 431 patients, 31.3% (135) were below 30 years old, while 68.7% (296) were 30 years old or above. Around 31.1% (134) had measurable assay levels (20 - 2000 (Taq) IU/mL); 21.8% (94) had below 20 IU/mL; and 13.2% (57) had above 2000 IU/ml approximately 21.1% (91) had no detectable HBV DNA in their samples. 12.8% (55) of the patients had levels greater than 20000 IU/mL. The distribution of HBsAg positivity among the patients shows an increasing trend from the lower age group 0-10 to 21-30 in males and from 31-40 in females, then a decreasing trend from 31-40 to 81-90 age group in males and from 41-50 to 81-90 age group in females. A total of 431 patients were investigated for hepatitis B viral load, of whom 90.2% were HBeAg negative and 9.8% were HBeAg positive.

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Section: Discussioncontrasting

confidence: 99%

Hepatitis B DNA quantification in the serum of hepatitis B surface antigen-positive patients in Benghazi

Abdeldaim,

Abdraba,

Qowaider

et al. 2022

sjuob

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“…16 The reported prevalence in this study is a cause for alarm because it is high enough to warrant the initiation of routine antenatal screening for HBV infection. This is because HBV positive pregnant women represent a major reservoir of the virus in a community and this can be passed on to the children either vertically or even horizontally Onwuliri et al 11 In this study women aged 20-29 recorded 6.1% prevalence compared to other age group with the lowest prevalence of 2.8% recorded among subjects aged 40-49, this is however contrary to the report of Pennap et al, 9 who recorded a high prevalence of 12.5% among pregnant women aged 40-44.The resultant high prevalence among this age group in our study is attributed to the fact that these women fall within the sexually active age bracket according to Zali et al 17 Age is an important factor in epidemiology studies hence the age of acquiring infection was found to be a major determinant of the incidence of HBV. Most of the women studied were in the 2 nd trimester of gestation, this group also had the highest HBsAg seropositivity of 12.8%, the result obtained in this study is lower than those of Ndams et al 10 who obtained a prevalence of 13.4% at the 2 nd trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 98%

“…recorded 12.3% prevalence in a study conducted among pregnant women in Minna, and the ones carried out by Onwuliri et al11 where a prevalence of 16.6% was recorded in a study among pregnant women in Vom.…”

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confidence: 90%

Sero-survey of Hepatitis B surface antigen amongst pregnant women attending Infectious Disease Hospital Bayara, Bauchi State, Nigeria

Ndako¹,

Echeonwu²,

Nwankiti

et al. 2012

Microbiol Res (Pavia)

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Hepatitis B virus (HBV) continues to cause serious health problems in developing countries. Neonatal infection with HBV, which is often acquired during delivery, carries a high risk resulting in persistent infection. This research aims to detect the prevalence of Hepatitis B surface Antigen (HBsAg) among pregnant women in our location of study. One hundred and eighty (180) sera samples were screened among pregnant women aged 13-49, using standard enzyme-linked immunosorbent assay (ELISA) method. Structured questionnaire were administered to the subjects to obtain demographic and other relevant data. Overall result showed that 31 (17.2%) were found to be positive for HBsAg among the total subjects screened. The highest prevalence was found among those aged 20-29 with 11 (6.1%) seropositivity (x2=7.902; P=0.048). Considering occupational distribution of volunteer subjects, a high prevalence of 12 (6.7%); P<0.05 was recorded among house wives, which shows a measure of significance compared to other women screened. Furthermore, based on various risk factors subjects with history of surgery and use of unsterilized sharp instruments recorded 15 (8.3%) prevalence (P=0.233; P>0.05). How ever, women in their second trimester of pregnancy recorded a higher prevalence of 23 (12.8%):(P=0.080; P<0.05). This study therefore emphasizes the public health importance of HBV among pregnant women and equally suggests that children born to women with Hepatitis B Virus, be closely monitored for infection beyond the one and the half years of age, this also calls for a proper enlightenment on the dangers posed by the virus, while a well designed vaccination schedule is advocated among the general population

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Seroprevalence of Hepatitis B surface antigen (HBSAG) among pregnant women in Aboh Mbaise local government area of Imo State, Nigeria

Cited by 2 publications

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Hepatitis B DNA quantification in the serum of hepatitis B surface antigen-positive patients in Benghazi

Hepatitis B DNA quantification in the serum of hepatitis B surface antigen-positive patients in Benghazi

Sero-survey of Hepatitis B surface antigen amongst pregnant women attending Infectious Disease Hospital Bayara, Bauchi State, Nigeria

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