Seroprevalence of Hepatitis B, Hepatitis C, and human immunodeficiency virus among healthy voluntary first-time blood donors in Kolkata

Abstract

Background: Transfusion transmitted infections (TTIs) threaten safety of the recipients and the community as a whole and are a subject of real concern worldwide. Aims and Objectives: To know prevalence of Hepatitis-B (HBV), Hepatitis-C (HCV), and Human immunode iciency virus (HIV) in voluntary irst-time blood donors. Design and Setting: Cross-sectional observational study done in a teaching hospital. Materials and Methods: A total of 3 745 voluntary irst-time blood donors were recruited and tested for HBV, HCV, and HIV with Enzyme-linked immunosorbent assay (ELISA). Results and Analysis: Among 3 745 blood donors, majority (90.95%) were male and 18 to 39 years age group. Prevalence of HBV was higher than HCV and HIV. HBV was maximum in 40 to 49 years (2.25%) and 18 to 29 years (1.86%) age group, whereas HCV and HIV were maximum in >50 years age group (0.93% and 1.86%, respectively). HIV positivity showed increasing prevalence with increase in age. Statistical Analysis: Statistical analysis was done using %, Chi square test, and Chi square for trend analysis. Conclusion: Seroprevalence of HBV, HCV, and HIV in voluntary blood donors is high in Kolkata and is high throughout this decade. Prevalence is even higher in other parts of India and Indian subcontinent. As voluntary blood donations are the major source of blood supply, chance of TTIs are very high in this part of the world.

Prevalence of Antibodies to Hepatitis C Virus in Voluntary Blood Donors: Are Women Better Donors?

“…Similar findings were reported from Andhra Pradesh and Orissa [6,7]. A report from West Bengal [8] showed 0.59% seroprevalence in female VBD. The higher prevalence in males which was seen, may be because more males opt for blood donation and hence, more males are tested.…”

Assessment of prevalence of sexually transmissible infections among voluntary blood donors and its comparison with replacement donors at Hassan Institute of Medical Science, Hassan, Karnataka, India

“…13 When we compare the global prevalence of STDs, we also noticed in present study that there is high prevalence of hepatitis B infection among other STD's suggests further community-based studies to screen for risk factors in the communities for blood born infections. Blood banks in India screen only for HBSag as a marker for HBV which is not sensitive enough to screen during window period so that there is a high chance for recipient to get infected if this blood is transfused.…”

Study of Seroprevalence of HIV, Hepatits B and C And Syphilis Among Blood Donors In A Tertiary Care Hospital, Kolkata

“…Prevalence of HBV, HCV, and HIV among the healthy blood donors or the replacement donors reflects the disease prevalence in the community. [5] Due to limitation in current blood screening practices in developing countries, donation by such individual is a potential threat to recipients. [6] A WHO report states that the viral dose in HIV transmission through blood is so large that one HIV positive transfusion leads to death on an average after two years in children and after three to five years in adults.…”