Seroprevalence of hepatitis A antibodies among children in a Saudi community

El‐Gilany, Abdel‐Hady; Hammad, Sabry Mohamed; Refaat, Khaled; Al-Enazi, Reda

doi:10.1016/s1995-7645(10)60068-5

Cited by 12 publications

(10 citation statements)

References 13 publications

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“…In 2007, the Ministry of Health in Saudi Arabia reported viral hepatitis as the second most common viral disease in the country with HAV contributing to 16% following Hepatitis B virus (52%) and Hepatitis C virus (32%) . Similar to Iran and Turkey, HAV seroprevalence data from Saudi Arabia have shown variations in anti‐HAV antibodies in different regions . A marked decrease in the prevalence of HAV has been reported in 2008 (18.6%) among Saudi children and adolescents as compared to 52% and 25% reported in 1989 and 1997, respectively.…”

Section: Resultsmentioning

confidence: 99%

Hepatitis A virus in the Middle East and North Africa region: a new challenge

Melhem

Talhouk

Rachidi

et al. 2014

Journal of Viral Hepatitis

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During the past three decades, a gradual shift in the age of infection with hepatitis A virus (HAV) from early childhood to adulthood has been observed. There is a general lack of updated data on HAV burden of disease, incidence and age-specific seroprevalence in countries of the Middle East and North Africa (MENA) region. The aim of this article is to review the published data on anti-HAV seroprevalence, an important tool to monitor infections rates, in countries of the MENA region and associated risk factors including water and socioeconomic data when available. Data on anti-HAV seroprevalence were found for 12 of 25 MENA countries. We show that MENA countries, similar to other areas in the world, have a clear shift in HAV incidence with a decline among young age groups and an increase among adults and older individuals. This would likely be associated with increased morbidity and increased risks of outbreaks among younger age groups. Consequently, the continuous surveillance of hepatitis A cases and the inclusion of hepatitis A vaccine in the expanded immunization programmes are needed in countries of the MENA.

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Section: Resultsmentioning

confidence: 99%

Hepatitis A virus in the Middle East and North Africa region: a new challenge

Melhem

Talhouk

Rachidi

et al. 2014

Journal of Viral Hepatitis

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“…[55] A cross-sectional, sero-epidemiological investigation of HAV among children aged 1-6 years in the province of Northern borders between 2006 and 2007 revealed a 33.8% HAV-IgG prevalence overall. [64] The most significant independent predictors of infection included rural residence, non-Saudi nationality, and availability of safe municipal water. The nationality factor suggests a more rapid decline in HAV endemicity in the local population, which has a higher per capita income compared to other Middle Eastern countries.…”

Section: Hepatitis Amentioning

confidence: 99%

Epidemiology of viral hepatitis in Saudi Arabia: Are we off the hook?

Abdo

Sanai

Al-Faleh

2012

Saudi J Gastroenterol

130

114

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Some 400 million people worldwide are currently infected with the hepatitis B virus (HBV), and the infection is common in the Middle East. Another 170 million people around the globe presently live with chronic hepatitis C virus (HCV) infection. Both HBV and HCV represent a worldwide epidemic. Despite significant decline in the prevalence of HBV and HCV infection in Saudi Arabia, these viral diseases cause significant morbidity and mortality, and impose a great burden on the country's healthcare system. On the other hand, Saudi epidemiology studies have shown that the hepatitis A virus seroprevalence in the country has reduced considerably over the past two decades. The progress in mapping the epidemiological pattern of viral hepatitis in Saudi Arabia has not only aided our understanding of the disease, but has also exposed the small but relevant gaps in our identification of the intricate details concerning the disease's clinical expression. In this review, we aim to document the timeline of viral hepatitis epidemiology in Saudi Arabia, while summarizing the relevant published literature on the subject.

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“…19 However, some studies have shown that there is a significantly higher proportion of HAV infection in rural areas than in urban areas. 23,24 According to the findings of our study, to use clean water and proper sewage disposal were found to be protective against HAV infection. That has been reported previously in other studies.…”

Section: Discussionmentioning

confidence: 64%

Prevalence of hepatitis A virus in patients attending a referral hospital in Bubanza Province, Northwest Burundi

Harabandi¹,

Odari²,

Lihana³

2018

Int J Res Med Sci

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Background: Viral hepatitis is a public health problem wide world. Hepatitis A, transmitted by fecal-oral route, is an infectious viral disease caused by hepatitis A virus and mainly due to poor sanitation. This study aimed to determine the prevalence of hepatitis A virus and associated factors in patients attending Mpanda referral hospital in Northwest Burundi.Methods: A cross-sectional study was done from November 2017 to January 2018 on 385 participants aged 2 years and above. Participants were recruited using a systematic random sampling technique. Data were collected using questionnaire from consented/assented participants. Five millilitres of venous blood was collected and analyzed. Anti-hepatitis A virus antibodies were screened using Enzyme Immuno Assay. Data were analyzed using Statistical Package for the Social Sciences version 16.0 software. A descriptive analysis was followed by bivariate analysis using a Chi-square test for comparison of various sub-groups with 5% statistical significance level. Odds ratio and 95% Confidence Intervals were calculated and presented.Results: The median age of the participants was 23 years and the range 72 years. The overall prevalence of Hepatitis A virus was 60.3%. There was a significant association between age [OR=7.22 (4.04-12.93), P <0.001], lack of clean water [OR=10.07 (5.63-18.01), P <0.001], traditional latrines [OR=1.86 (1.02-3.40), P=0.04] and Hepatitis A Virus seroprevalence.Conclusions: Present study shows high prevalence of HAV infection in patients attending Mpanda Referral Hospital. Younger age, lack of clean water and traditional latrines play roles in increasing prevalence of HAV infection in both rural and urban areas.

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Seroprevalence of hepatitis A antibodies among children in a Saudi community

Cited by 12 publications

References 13 publications

Hepatitis A virus in the Middle East and North Africa region: a new challenge

Hepatitis A virus in the Middle East and North Africa region: a new challenge

Epidemiology of viral hepatitis in Saudi Arabia: Are we off the hook?

Prevalence of hepatitis A virus in patients attending a referral hospital in Bubanza Province, Northwest Burundi

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