Seroprevalence of Helicobacter pylori in Chile: Vegetables May Serve as One Route of Transmission

Hopkins, Robert J.; Víal, Pablo A.; Ferreccio, Catterina; Ovalle, Juan Pablo; Prado, P.; Sotomayor, Viviana; Russell, Robert G.; Wasserman, Steven S.; Morris, James G.

doi:10.1093/infdis/168.1.222

Cited by 230 publications

(143 citation statements)

References 10 publications

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“…Alcohol consumption and smoking were also not associated with infection [16,17]; the same was true for recent antibiotic use and contact with pets [18]. Some epidemiological studies have indicated an association between the ingestion of raw vegetables and H pylori infection [19]. We found no such association, nor did Brown et al [20].…”

Section: Discussionsupporting

confidence: 42%

Helicobacter pylori infection in adults from a poor urban community in northeastern Brazil: demographic, lifestyle and environmental factors

Marzano‐Rodrigues¹,

Queiroz²,

Rodrigues³

et al. 2005

Braz J Infect Dis

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We investigated the prevalence and the risk factors for infection with Helicobacter pylori in a randomly-selected population of adults from a low-income community in Northeastern Brazil. Helicobacter pylori infection was determined by ELISA. Risk factors were assessed using a structured interview. Two hundred and four individuals were included in the study, including 49 males and 155 females, ranging from 18 to 80 years old. Overall, 165 of 204 participants (80%) were H. pylori positive, without significant gender differences (p= 0.49). The infection rate was of 84.7% in subjects 18 to 30 years of age, increasing to 92% in subjects 46-60 years old. Above 60 years old, the prevalence decreased slightly. As a whole, the prevalence of infection did not increase significantly (p=0.147) with age. There were no significant differences in the prevalence of H. pylori infection, when patients were classified by age, smoking habit, educational level, alcohol consumption, the number of persons per room, the number of children per household, the number of adults per household, cup-sharing, household pets, toilet location, number of persons per bed and medical history of antibiotic and raw vegetable ingestion. In conclusion, no risk factors associated with infection was found in these adults, suggesting that the infection, even in a poor population, may be acquired predominantly during childhood; the relatively high prevalence that we observed may be more due to a cohort effect than to acquisition of infection during adulthood.

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Section: Discussionsupporting

confidence: 42%

Helicobacter pylori infection in adults from a poor urban community in northeastern Brazil: demographic, lifestyle and environmental factors

Marzano‐Rodrigues¹,

Queiroz²,

Rodrigues³

et al. 2005

Braz J Infect Dis

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“…This could explain the wide range of habits and conditions, including cutlery sharing, bed sharing, overcrowding, consumption of raw food and presence of pets, that have been found to be associated with infection in different studies. [33][34][35][36] A recent study on the seroprevalence of infection among blood donors identified race (nonwhite), low educational level, previous endoscopy and age as risk factors for H. pylori seropositivity in a multivariate analysis. 37 Other authors have stressed that the water supply could be the source of the infection, but this variable was not tested in the present study, since all the subjects had access to the same water distribution system.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

et al. 2010

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CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING:Cross-sectional study, among patients attended at an outpatient clinic.METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age.CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence. RESUMO CONTEXTO E OBJETIVO:A infecção por Helicobacter pylori é adquirida principalmente na infância e é associada a morbidade significativa em adultos.O objetivo foi avaliar a soroprevalência de infecção por H. pylori bem como fatores de risco em crianças de baixo nível socioeconômico atendidas em um hospital público em São Paulo, Brasil. TIPO DE ESTUDO E LOCAL:Estudo transversal, realizado entre pacientes atendidos em ambulatório. MÉTODOS:Foram avaliadas 326 crianças (150 meninos e 176 meninas, idade: média 6,82 ± 4,07 anos) em estudo transversal. Foram excluídas aquelas com doenças crônicas, tratamento prévio de H. pylori e cujo responsável não consentiu participar do estudo. Os responsáveis responderam questionário demográfico e foi coletada uma amostra de sangue. O teste sorológico empregado foi o CobasCore II, exame de segunda geração, sendo considerados positivos títulos > 5 U/ml. RESULTADOS:Infecção por H. pylori foi diagnosticada em 116 (35,6%). A idade dos pacientes infectados foi maior que a dos demais (7,77 ± 4,08 anos versus 5,59 ± 3,86 anos; p < 0,0001). A prevalência aumenta de 20,8% entre dois e quatro anos de idade para 58,3% entre maiores de 12 anos. Não houve relação significativa entre soropositividade e sexo, raça, aleitamento materno, número de pessoas ou de cômodos na casa, compartilhamento de camas, domicílio em favela, escolaridade mat...

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“…This differential susceptibility may be directly related to the long-term clinical outcome. It has been reported that the males are at a greater risk of H pylori clinical manifestations [36,37] . These observation may account for higher prevalence of duodenal ulcer and gastric cancer in males.…”

Section: Discussionmentioning

confidence: 99%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS:The seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001). CONCLUSION:These results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori -specific antibodies influenced by age and sex of subjects. Moreover, it seems that males are more susceptible to infection with CagA + strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.

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Seroprevalence of Helicobacter pylori in Chile: Vegetables May Serve as One Route of Transmission

Cited by 230 publications

References 10 publications

Helicobacter pylori infection in adults from a poor urban community in northeastern Brazil: demographic, lifestyle and environmental factors

Helicobacter pylori infection in adults from a poor urban community in northeastern Brazil: demographic, lifestyle and environmental factors

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

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