Seroprevalence of dengue in school children in Mexico ages 6–17 years, 2016

Amaya-Larios, Irma Y.; Rojas-Russell, Mario; López-Cervantes, Malaquı́as; Castro-Porras, Lilia; Castro-Borbonio, Ma Victoria; Sarti, Elsa; Puentes-Rosas, Esteban; Tirado-Gómez, Laura Leticia; Olaíz-Fernández, Gustavo; Ramos‐Castañeda, José

doi:10.1093/trstmh/try046

Cited by 9 publications

(7 citation statements)

References 21 publications

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“…We estimate that 81% of individuals aged 2–40 years been infected by DENV at least once, and that on average, 12% of the susceptible population gets infected each year. This high transmission intensity is consistent with that reported in other endemic areas of the world such as Thailand, Nicaragua, Brazil and Mexico[ 20 – 21 ]. In contrast to other studies that have found strong associations between socio-economic [ 22 – 25 ], demographic [ 26 – 32 ], and behavioral [ 33 – 37 ] variables and DENV transmission, our findings are consistent with a spatially homogeneous transmission and no evidence of any housing or environmental factors related to prior exposure to DENV.…”

Section: Discussionsupporting

confidence: 91%

Heterogeneity of dengue transmission in an endemic area of Colombia

et al. 2020

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Population based serological surveys are the gold-standard to quantify dengue (DENV) transmission. The purpose of this study was to estimate the age-specific seroprevalence and the force of infection of DENV in an endemic area of Colombia. Between July and October 2014, we conducted a household based cross-sectional survey among 1.037 individuals aged 2 to 40 years living in 40 randomly selected locations in urban Piedecuesta, Santander, Colombia. In addition, we also enrolled 246 indviduals living in rural “veredas”. Participants were asked to answer a questionnaire that included demographic, socioeconomic and environmental questions and to provide a 5 ml blood sample. Sera were tested using the IgG indirect ELISA (Panbio) kit to determine past DENV infection. The overall DENV seroprevalence was 70% (95% CI = 67%-71%), but was significantly higher in urban (81%, 95% CI = 78%-83%) as compared to rural (21%, 95% CI = 17%-27%) locations. Age was a major predictor of seropositivity, consistent with endemic circulation of the virus. Using catalytic models we estimated that on average, 12% (95%CI = 11%-13%) of susceptible individuals living in the city are infected by DENV each year. Beyond age, the only predictor of seropositivity in urban locations was prior history of dengue diagnosed by a physician (aPR 1.15, 95% CI = 0.98–1.35). Among participants living in rural settings, those that reported traveling outside of their vereda were more likely to be seropositive (aPR 3.60, 95%CI = 1.54–8.42) as well as those who were born outside of Santander department (aPR = 2.77, 95%CI = 1.20–6.37). These results are consistent with long term endemic circulation of DENV in Piedecuesta, with large heterogeneities between urban and rural areas located just a few kilometers apart. Design of DENV control interventions, including vaccination, will need to consider this fine scale spatial heterogeneity.

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Section: Discussionsupporting

confidence: 91%

Heterogeneity of dengue transmission in an endemic area of Colombia

et al. 2020

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“…This suggests that an important proportion of the population could be naïve to dengue, even in the adult population where the highest seroprevalence was observed. The trend of increased seroprevalence with age is also consistent with the results of the cross-sectional study [ 27 ]. Moreover, the serotyping results from the four RT-qPCR-confirmed cases were in accordance with the serotypes observed by the Mexican surveillance system of dengue as DENV-1 was almost exclusively detected in cases reported in Jalisco in 2016 and 2017 [ 15 , 16 ].…”

Section: Discussionsupporting

confidence: 89%

“…The number of virologically confirmed dengue cases was close to the number expected at study design, yielding an incidence proportion of 1.4%. Moreover, the overall seroprevalence in this community (19.4%; 95% CI 14.5-25.6) was close to estimates from a cross-sectional study conducted in children aged 6-17 years old from 22 endemic states in Mexico in which the seroprevalence in seven clustered states including Jalisco was 13.3% (95% CI 9.0-19.2) [27]. This suggests that an important proportion of the population could be naïve to dengue, even in the adult population where the highest seroprevalence was observed.…”

Section: Discussionsupporting

confidence: 79%

Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco

DeAntonio¹,

Amaya-Tapia

Ibarra-Nieto

et al. 2021

PLoS ONE

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Background and objectives The burden of dengue virus (DENV), a mosquito-borne pathogen, remains difficult to assess due to misdiagnosis and underreporting. Moreover, the large proportion of asymptomatic dengue cases impairs comprehensive assessment of its epidemiology even where effective surveillance systems are in place. We conducted a prospective community-based study to assess the incidence of symptomatic dengue cases in Zapopan and neighboring municipalities in the state of Jalisco, Mexico. Methods Healthy subjects aged 6 months to 50 years living in households located in the Zapopan and neighboring municipalities were enrolled for a 24-month follow-up study (NCT02766088). Serostatus was determined at enrolment and weekly contacts were conducted via phone calls and home visits. Participants had to report any febrile episode lasting for at least two days. Suspected dengue cases were tested by reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), detection of non-structural protein 1 (NS1), anti-DENV immunoglobulin G and M (IgG and IgM) assays. Results A total of 350 individuals from 87 households were enrolled. The overall seroprevalence of anti-DENV IgG at enrolment was 19.4% (95% confidence interval [CI] 14.5–25.6) with the highest seroprevalence rate observed in the adult group. Over the 27-month study period from July 2016 to September 2018, a total of 18 suspected dengue cases were reported. Four cases were confirmed by RT-qPCR and serotyped as DENV-1. A fifth case was confirmed by the NS1 assay. The 13 remaining suspected cases were tested negative by these assays. Based on the 5 virologically confirmed cases, symptomatic dengue incidence proportion of 1.4% (95%CI 0.5–3.8) was estimated. No severe cases or hospitalizations occurred during the study. Conclusion Community-based active surveillance was shown as efficient to detect symptomatic dengue cases. Clinical trial registration NCT02766088.

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“…Our results are in agreement with previous studies in Nicaragua, Brazil and Honduras, where patients with Zika tend to be older, less frequently men, or more educated than people with dengue and other febrile episodes [ 19 , 25 , 26 ]. This is consistent with differences in risk-environments in neighborhoods, work, but also determined by mobility, age, gender, individual behavior, education, and socioeconomic status [ 9 , 27 , 28 ]. We also observed that it took longer after symptoms onset for people with dengue to seek care than for patients with Zika and UIE.…”

Section: Discussionsupporting

confidence: 78%

“…The study was conducted in the city of Tapachula, Chiapas, located 23 km west of the border with Guatemala along the Pacific coast (see Map 1 ). This area is considered hyperendemic for dengue, with an estimated seroprevalence of 83% (95% CI 73.8–88.9) in school children aged 13–17 years [ 9 ]. Participants were enrolled in two primary healthcare centers from Instituto Mexicano del Seguro Social—Mexican Institute of Social Security (Unidad de Medicina Familiar No.11), and from Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado -Institute of Social Security and Services for Government Employees (Clínica Dr. Roberto Nettel Flores), one General Hospital from the State of Chiapas Ministry of Health (Hospital General de Tapachula) and a tertiary care hospital from the National Ministry of Health (Hospital Regional de Alta Especialidad Ciudad Salud).…”

Section: Methodsmentioning

confidence: 99%

Different epidemiological profiles in patients with Zika and dengue infection in Tapachula, Chiapas in Mexico (2016–2018): an observational, prospective cohort study

et al. 2021

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Background The introduction of Zika and chikungunya to dengue hyperendemic regions increased interest in better understanding characteristics of these infections. We conducted a cohort study in Mexico to evaluate the natural history of Zika infection. We describe here the frequency of Zika, chikungunya and dengue virus infections immediately after Zika introduction in Mexico, and baseline characteristics of participants for each type of infection. Methods Prospective, observational cohort evaluating the natural history of Zika virus infection in the Mexico-Guatemala border area. Patients with fever, rash or both, meeting the modified criteria of PAHO for probable Zika cases were enrolled (June 2016–July 2018) and followed-up for 6 months. We collected data on sociodemographic, environmental exposure, clinical and laboratory characteristics. Diagnosis was established based on viral RNA identification in serum and urine samples using RT-PCR for Zika, chikungunya, and dengue. We describe the baseline sociodemographic and environmental exposure characteristics of participants according to diagnosis, and the frequency of these infections over a two-year period immediately after Zika introduction in Mexico. Results We enrolled 427 participants. Most patients (n = 307, 65.7%) had an acute illness episode with no identified pathogen (UIE), 37 (8%) Zika, 82 (17.6%) dengue, and 1 (0.2%) chikungunya. In 2016 Zika predominated, declined in 2017 and disappeared in 2018; while dengue increased after 2017. Patients with dengue were more likely to be men, younger, and with lower education than those with Zika and UIE. They also reported closer contact with water sources, and with other people diagnosed with dengue. Participants with Zika reported sexual exposure more frequently than people with dengue and UIE. Zika was more likely to be identified in urine while dengue was more likely found in blood in the first seven days of symptoms; but PCR results for both were similar at day 7–14 after symptom onset. Conclusions During the first 2 years of Zika introduction to this dengue hyper-endemic region, frequency of Zika peaked and fell over a two-year period; while dengue progressively increased with a predominance in 2018. Different epidemiologic patterns between Zika, dengue and UIE were observed. Trial registration Clinical.Trials.gov (NCT02831699).

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Seroprevalence of dengue in school children in Mexico ages 6–17 years, 2016

Cited by 9 publications

References 21 publications

Heterogeneity of dengue transmission in an endemic area of Colombia

Heterogeneity of dengue transmission in an endemic area of Colombia

Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco

Different epidemiological profiles in patients with Zika and dengue infection in Tapachula, Chiapas in Mexico (2016–2018): an observational, prospective cohort study

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