Seroprevalence of cytomegalovirus among healthy students at Diyala University, Diyala, Iraq

Khudir, Mohammed Khaleefah; Molan, Abdul-Lateef

doi:10.9790/3008-09155961

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…The results of this study showed the prevalence rate of CMV IgG antibodies (96.6 %) were similar with previous studies performed the country in Sana'a (100%) and Hodeidah (98.7%) among pregnant women [3,4]. The results from our study nearly similar with studies performed in other developing countries in Iraq (97.4 %) and Iran (99.2%) among blood donors [8,9]. This rate 96.6% is higher than that reported by other studies performed in Japan and India showed 84% and 61% of adults had the antibodies respectively [10,11].…”

supporting

confidence: 83%

“…This IgM rate is lower than that reported from Nigeria in which 19.5 % of healthy blood donors had CMV IgM antibodies while this rate is higher than that reported by other studies performed in Iraq and Iran showed 1.6 % and 1.0 % of healthy blood donors had CMV IgM antibodies respectively [8,13,17]. While this rate is lower than that reported by other studies performed in Nigeria 28.0% [18].…”

Section: Resultscontrasting

confidence: 55%

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Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Al-Arnoot¹

2017

INID

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IntroductionCytomegalovirus (CMV) is a member of the human herpes family of viruses. It has emerged as a significant cause of morbidity and mortality in children and immunocompromised adults. It transmitted by direct or indirect, close or intimate person-to-person contact. Sources of the virus include oropharyngeal secretions, urine, cervical, vaginal excretions, semen, breast milk, tears, faeces and blood [1]. *Corresponding author:Saad Al-Arnoot, Microbiology Division, Department of Biology, Faculty of Science, Sana'a University, Sana'a, Yemen, Tel: +967 00967774667900; E-mail: saad.alarnoot@gmail.com According to the result of a WHO cooperative study involving equal numbers of male and female healthy blood donors between 20-40 years of age are shown. The seroprevalence of antibody in that study ranges from 40-100% [2]. However, in Yemen, a few studies have investigated the prevalence of CMV antibody which seroprevalence of CMV antibody ranges between 68%-100% among pregnant women [3][4][5].The American Association of Blood Banks has recommended transfusion from donors who are seronegative for CMV, or the use of deglycerolised Frozen Red Blood Cells (RBCs) for transfusion in a seronegative preterm (<1200 g) child born to a mother with negative or unknown immune status regarding CMV infection [6]. These guidelines have helped to eliminate transfusion-induced CMV infection syndrome in preterm infants in the West. However, since the vast majority of blood donors in developing countries are seropositive for CMV, it would be imprudent to screen blood donors for CMV as very few seronegative blood units would be available for transfusion. Other preventive strategies (such as leukoreduction filtration, saline-washed RBCs, frozen deglycerolised RBCs, etc.,) are increasingly recommended to minimize transfusion transmission of CMV. These methods may be more appropriate and cost effective in developing countries for the prevention of CMV transmission through infected blood to immunosuppressed individuals. More studies are needed to elucidate the transmission of transfusion-associated CMV before proper guidelines on routine CMV screening in blood donors can be formulated [7].Like other developing countries Yemeni blood donors are screened only for HIV, Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Syphilis. Also, there is no published data concerning CMV seroprevalence in blood donors in Yemen. Therefore the present study was undertaken to determine the prevalence of antibodies to CMV infection among male blood donors at the National Blood Transfusion and Research Center in Sana'a city, Yemen. It's a useful study for understanding situation of CMV infection in Yemen and offering the helpful data for government policymakers. Materials and MethodsA cross-sectional study was collected from 235 male healthy voluntary donors attending National Blood Transfusion and Research Center in Sana'a city, Yemen. About 5 ml blood samples was collected from each consenting subjects by venipuncture, transferred into sterile anticoag...

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confidence: 83%

Section: Resultscontrasting

confidence: 55%

Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Al-Arnoot¹

2017

INID

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“…However, the low level of education, inadequate sanitary conditions, cultural aspects, and families with a great number of individuals were already described as the main factors behind the elevated CVM prevalence rates [12,23,25]. Similarly, previous ndings showed CMV prevalence ranging from 75% to 97.7% among university students from Middle West [26,27].Nevertheless, the majority of students of the study population were very young, which may explain the low susceptibility to CMV infection veri ed in these groups once the prevalence rates were more prominent among older people.…”

Section: Discussionmentioning

confidence: 93%

Prevalence and Recurrence Rates of Cytomegalovirus Infection among Patients with Hematological Diseases of the Brazilian Western Amazon

Silva

Pinheiro-Silva

Oliveira

et al. 2021

Preprint

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Purpose: Cytomegalovirus (CMV) is a worldwide distributed pathogen that may cause serious complications in patients with hematological diseases. This study aimed to serologically characterize the CMV infection in patients suffering from hematological diseases in Amazonas, Brazil. Methods: Serum samples from 323 patients were tested for the presence of anti-CMV IgM or IgG antibodies by an enzyme-linked immunosorbent assay. Positive samples for IgM were submitted to the IgG avidity test to differentiate primary infection from recurrent infection. An epidemiological questionnaire was administered to collect sociodemographic information of the study population. Results: The overall prevalence of CMV infection verified in this study was 91.3%. The highest rates were found in patients suffering from platelet disorders (94.5%), anemia (93.3%), or leukemia (91%). The study population was predominantly composed of individuals with low socioeconomic status. Blood transfusions were more often in patients with anemia or leukemia, but it was not correlated with the positivity for CMV infection. Measurement of IgG avidity in patients positive for anti-CMV IgM demonstrated a recurrent infection rate of 5.2% (17/323). Over 80% of recurrent infection occurred in patients with acute lymphocytic leukemia (ALL) or anemia. Conclusions: Our findings indicated that CMV infection is highly prevalent in patients with hematological diseases from the Brazilian western Amazon. The prevalence observed progressively rose with increasing age, whereas anemia or ALL disease figured as risk factors for the recurrence of CMV infection.

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“…In addition, 3(2 females and 1 male) students (1.6%) were CMV IgM seropositive. 66 Based on these above studies it can be concluded that CMV has significant role in aborted women and other congenital problem. Moreover, CMV has wide distribution in different areas of Iraq.…”

Section: Studies About CMV With Other Diseasesmentioning

confidence: 94%

“…Just 2(6.5%) had CMV. 65 The last study was reported by Khudir et al 66 in 2014 in 186 healthy students at Diyala University. The diagnosis was based on the detection of CMV IgM and IgG.…”

Section: Studies About CMV With Other Diseasesmentioning

confidence: 94%

Untitled

2018

JMEN

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Therefore, it can be isolated from saliva, tears, breast milk, semen, cervical secretions, blood products and urine. HCMV infection may be either latent (non-productive), lytic (productive), asymptomatic or symptomatic. 4 CMV pathogenicityResearch to validate the correlation of CMV infection with age denoted the presence of three periods of increased incidence of infections: early childhood, adolescence and the reproductive period. The virus can be present in different secretions of an infected person, such as discharge from the oropharynx, urine, vagina, semen, milk, and blood components. The virus spreads by direct contact with an infected person, vertically from mother to fetus, and parenteral, i.e. blood transfusions, organ or bone marrow transplants. 15

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Seroprevalence of cytomegalovirus among healthy students at Diyala University, Diyala, Iraq

Abstract: Globally, cytomegalovirus (CMV) is an extremely common viral infection and is one of the most common causes of congenital infections. Although infection with CMV in immunocompetent individuals is selflimiting, infection in immunocompromised individuals

Cited by 5 publications

References 11 publications

Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Seroprevalence of Cytomegalovirus among Healthy Blood Donors in Sana'a City, Yemen

Prevalence and Recurrence Rates of Cytomegalovirus Infection among Patients with Hematological Diseases of the Brazilian Western Amazon

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