Seroprevalence of COVID-19 and associated factors in a medical institution in Pakistan

Naiyar, Iffat; Anjum, Aiman Farogh; Khalid, Ahmed M.; Noor, Iffat; Abdullah, Muhammad Saad; Anwar, Muhammad Zeeshan

doi:10.1016/j.jtumed.2021.04.004

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Additionally, the individuals washing their hands regularly were probably shaking hands with other individuals or not maintaining social distance leading to the high seroprevalence. The ndings are inconsistent with other studies, as (15) reported a signi cant association between washing hands, wearing masks, and reduction in seropositivity. Nonetheless, the ndings on the reduction of seroprevalence through social distancing corroborated this study.…”

Section: Discussioncontrasting

confidence: 99%

Seroprevalence of Anti-SARS-COV-2 Antibodies in Benadir Region, Somalia

Dirie¹,

Adam²,

Mohamoud³

et al. 2021

Preprint

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Background Only little is known about the true extent of COVID-19 in Somalia. The study aims to assess the seroprevalence of the COVID- 19 pandemics in the Benadir region using SARS-CoV-2 antibodies and estimate the number of inhabitants infected with SARS- CoV-2. Methods Population-based cross-sectional survey was conducted to measure the seroprevalence of antibodies against SARS-CoV-2 in the Benadir region (Mogadishu city). In the study, we enrolled 2500 Mogadishu city residents aged ≥18 years who did not receive the SARS-CoV-2 vaccine. Results The overall seroprevalence of IgG/IgM anti-SARS CoV- 2 antibodies was 44.8%. The seropositivity in females (56.6%) was higher than in males (46.2%). The trend in seropositivity increased with age; however, the variation was only significant in the age group 38-57 with an odds ratio and p-value of 4.11 (1.475-11.47), p=0.007. Families with >5 members (47.2%) were more likely to test positive than those <5 members (37%). Participants reported covid-19 symptoms during the pandemics or had contact with covid-19 patients have significantly increased IgG prevalence. Conclusion Participants with larger families, individuals working in the public sector, and students showed significant seropositive results. Therefore, precautionary measures should be heightened for individuals working in the public sector.

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Section: Discussioncontrasting

confidence: 99%

Seroprevalence of Anti-SARS-COV-2 Antibodies in Benadir Region, Somalia

Dirie¹,

Adam²,

Mohamoud³

et al. 2021

Preprint

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“…Furthermore, our study determined that the majority of respondents who developed SARS-CoV-2 antibodies did not develop symptoms, which may be due to abortive infections or asymptomatic infections. This finding was consistent with the results of Naiyar et al, 2021, who determined the seroprevalence of SARS-CoV-2 in a medical institution and stated that most (68.42%) of the technical staff and administrators who had positive IgG were asymptomatic [32]. Nevertheless, the asymptomatic individual can act as the source of the disease (silent transmission), as asymptomatic infections have the same infectivity as symptomatic infections [9].…”

Section: Plos Onesupporting

confidence: 90%

COVID-19: Establishing, implementing and assessment safety strategy, descriptive interventional study

et al. 2023

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The increase in severe acute respiratory syndrome SARS-CoV-2 has invariably affected medical professionals in their training, academic and professional development. The present study was an interventional descriptive study aimed at reducing the risk of exposure to COVID-19 and enabling physical attendance to the practical session for applied medical students by establishing and implementing a safety strategy. The adopted safety strategy has eight conditions and 50 requirements. Compliance with the safety strategy along with the serological diagnosis of COVID-19 was used as a key performance indicator for assessing the efficiency of the safety strategy. A total of 197 students were enrolled at the beginning of the study. The overall results showed that 78.1% of the respondents strictly followed the protocol, 14.5% of the individuals partially responded to the protocol and 7.4% of the individuals did not respond to the protocol. Twenty-two (12.6%) out of the 175 participants who completed the study had positive COVID-19 during the study period, whereas the remaining 153 participants (87.4%) appeared to be healthy. The serological results showed that 68 (38.9%) and 66 (37.7%) individuals of the study population had positive IgM+IgA and IgG of COVID-19, respectively; the majority of the participants who developed antibodies did not show symptoms and appeared to be healthy during the study. The physical distancing condition was the only condition that displayed a significant relationship with seropositive IgM+IgA. The compiling of standardized protocols along with serological diagnoses can be an effective tool in measuring the effectiveness of safety protocol and reducing the risk of exposure to COVID-19.

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“…After obtaining serum samples, for patients with prior SARA-CoV-2 infection, Ichroma -which is a COVID-19 IgG antibody test against virus nucleocapsid protein (NP) with sensitivity and specificity of 95.8% and 97.0%, respectively -was used as a medical instrument for in vitro diagnosis [16]. A positive result was defined as an IgG level of 1.1 or more [17]. As the coronavirus spike (S) protein serves as the immunogen in all approved vaccines (except Sinopharm, which is based on the inactivated virus) [18], an antibody against S protein was used as a measure for humoral immunity elicited by these vaccines [19,20].…”

Section: Measurements and Instrumentsmentioning

confidence: 99%

Humoral immune response to COVID-19 infection or vaccination among celiac disease patients

Albatayneh¹,

Alabdallat²,

Kreishan³

et al. 2022

cejoi

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Introduction: Celiac disease (Cd) is the most common autoimmune disease (ad) of the small intestine, affecting 1-2% of the population globally. it is characterized by the serological presence of autoantibodies (abs), tissue transglutaminase antibody (ttGa), immunoglobulin (ig) a, and igG. Production of antibodies against sars-CoV-2 after infection with the virus or vaccination is not well understood, especially among Cd patients. the goal of this study was to measure the igG antibodies in Jordanian patients infected with or vaccinated against the sars-CoV-2 virus with different types of vaccines (Pfizerbiontech bnt162b2, sinopharm bbibP-CorV or oxford-astraZeneca Chadox1-s) and compare them with the levels in non-celiac controls. igG levels induced by different vaccines were also compared.Material and methods: the data for this cross-sectional study were obtained via a survey, whereby respondents were identified through convenience sampling. the healthy controls were given Questionnaire a while Cd patients completed Questionnaire b. the blood samples from all participants were tested for the CoVid-19 nucleocapsid protein (nP) igG serum levels for participants previously infected with sars-CoV-2, and spike (s) protein (s1/s2) igG serum levels for vaccine recipients.Results: the study involved 116 individuals, 60 (51.7%) of whom were Cd patients. the nP igG serum levels in the infected and s1/s2 igG levels in the vaccinated Cd patients were significantly lower than the levels in controls (48.3 ±44.5 vs. 81.1 ±34.4 and 49 ±45.8 vs. 75.7 ±38.6, p = 0.002). moreover, only the Pfizer vaccine induced significantly more igG antibodies in controls compared to Cd patients (88.8 ±29.1 vs. 58.3 ±45.4, p = 0.01). on the other hand, the igG levels were significantly higher in Cd patients who received the Pfizer relative to the astraZeneca vaccine (58.3 ±45.5 vs. 13.0 ±23.6, p = 0.03). after adjusting for presence of Cd, age, sex, body mass index (bmi), comorbidities, vaccine type, smoking, gluten adherence, and time since infection or vaccination, sars-CoV-2 s1/s2 igG abs and/or nP igG abs positivity was significantly associated with Cd absence and negatively with vaccine type (astraZeneca) with the odds ratios (ors) of 9.6 (95% Ci = 1.5-59.2, p = 0.015) and 0.03 (95% Ci = 0.004-0.244. p = 0.001), respectively.Conclusions: We concluded that patients with Cd had lower sars-CoV-2 s1/s2 igG abs and nP igG abs levels than controls, and Cd patients who received the Pfizer vaccine had higher igG levels than patients who received the astraZeneca vaccine. We recommend that further research be conducted to address the dynamics of the antibody responses in Cd patients regarding CoVid-19 infection.

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Seroprevalence of COVID-19 and associated factors in a medical institution in Pakistan

Cited by 5 publications

References 23 publications

Seroprevalence of Anti-SARS-COV-2 Antibodies in Benadir Region, Somalia

Seroprevalence of Anti-SARS-COV-2 Antibodies in Benadir Region, Somalia

COVID-19: Establishing, implementing and assessment safety strategy, descriptive interventional study

Humoral immune response to COVID-19 infection or vaccination among celiac disease patients

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