Seroprevalence of celiac disease among United Arab Emirates healthy adult nationals: A gender disparity

Abu-Zeid, Yousif A.; Jasem, Waheeba S; Lebwohl, Benjamin; Green, Peter H.; ElGhazali, Gehad

doi:10.3748/wjg.v20.i42.15830

Cited by 25 publications

(24 citation statements)

References 33 publications

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“…Celiac disease is a throughout life disorder caused by ingested cereal-derived gluten in predisposed individuals [3]. Since celiac disease is common but difficult to detect because of the heterogeneous clinical picture, a wide scale screening of the whole population with .The present study also showed that the prevalence of celiac disease was more frequent among females than males, this was compatible with most of the celiac disease epidemiological studies reported by Aljebreen AM, et al, 2013 study [19] and Abu-Zeid YA, et al, 2014 study [16] which concluded that celiac disease affected females more frequently than males. Possibly females are genetically more susceptible to environmental exposure factors that impact the immunological processes and resulting CD [26] because the genetic predisposition HLA DQ2/DQ8, are more recurrent in female compared to male CD patients [27].In conclusion, the high prevalence rate of seropositivity of celiac disease among healthy student individuals and is found in female students more than males.…”

Section: Discussionsupporting

confidence: 87%

Screening for Celiac Disease Using Anti-Tissue Transglutaminase Antibody Assays in Healthy Students Individuals

Hameed¹

2017

DJPS

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This study was aimed to determine the prevalence of seropositivity of celiac disease among apparently healthy individuals. Between December / 2014 to March / 2015, eighty four apparently healthy students (42 males and 42 females) of the Technical College/Kirkuk with mean age ± standard deviation of 22.25 ± 2.85 years where participated in the study. All subjects were serologically screened for the presence of immunoglobulin A and G of antitissue transglutaminase antibodies (IgA-tTG and IgG-tTG) by using Enzyme-Linked Immunosorbent Assay (ELISA). In total, 84 students (42 males and 42 females). There was only five students (5.9%) who had a seropositive for celiac disease, including 4 females and 1 male, among them only one female showed positive results of both IgA and IgG anti-tissue transglutaminase antibodies (IgA-tTG and IgG-tTG), while the remaining students (3 females and 1 male) revealed negative results of IgA anti-tissue transglutaminase antibodies and positive results of IgG anti-tissue transglutaminase antibodies. The Computerized Microsoft Excel program was performed by using proportions and mean ± standard deviation. In conclusions, positive celiac screening is existent at a high prevalence rate in our healthy individuals, in which the individuals' IgA deficiency are detected with the positivity of IgG anti-tissue transglutaminase antibodies. Females are more affected than males. A study widely is needed to estimate the real prevalence by substantiation of positive cases with histological examination.

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Section: Discussionsupporting

confidence: 87%

Screening for Celiac Disease Using Anti-Tissue Transglutaminase Antibody Assays in Healthy Students Individuals

Hameed¹

2017

DJPS

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“…Studies on the prevalence of CD in the general population are available only from seven Asian countries. Although population‐based studies are not available from many Asian countries, the presence of CD has been described in the form of case‐series from China, Iraq, Pakistan, Uzbekistan, Kuwait, Lebanon, Oman, Syria, Taiwan, Singapore, Japan, and United Arab Emirates . In addition, case reports of CD have been published from some other Asian countries such as Bangladesh, South Korea, and Yemen .…”

Section: Discussionmentioning

confidence: 99%

“…Although populationbased studies are not available from many Asian countries, the presence of CD has been described in the form of case-series from China, Iraq, Pakistan, Uzbekistan, Kuwait, Lebanon, Oman, Syria, Taiwan, Singapore, Japan, and United Arab Emirates. 24,25,27,[44][45][46][47][48][49][50][51] In addition, case reports of CD have been published from some other Asian countries such as Bangladesh, South Korea, and Yemen. [52][53][54] There still are no reports on CD from many Asian countries such as Azerbaijan, Kazakhstan, Turkminstan, Afganistan, Kyrgyzstan, Tajikistan, Cambodia, Myanmar, Vietnam, Mongolia, Nepal, and Bhutan.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of celiac disease in Asia: A systematic review and meta‐analysis

Singh

Arora

Singh

et al. 2016

J of Gastro and Hepatol

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“…However, the prevalence in different ethnicities varies. (2) The prevalence of CD among Europeans is thought to be about 1-1.5% (2) with a similar estimated prevalence of about 1.1% in the adult Israeli population (3) and 1.2% in the United Arab Emirates, (4) while the disease appears to be less common in Indonesia, (2) South Korea, (2) and the Philippines (2), which may be related to the lower consumption of wheat in those populations. A retrospective study from the Northern part of India reported a significant increase in the prevalence of CD in the past decade.…”

Section: Introductionmentioning

confidence: 99%

Ethnic Variations in Duodenal Villous Atrophy Consistent With Celiac Disease in the United States

Krigel

Turner

Makharia

et al. 2016

Clinical Gastroenterology and Hepatology

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Background & Aims Celiac disease is a common disorder with a worldwide distribution, though the prevalence among different ethnicities varies. We aimed to measure the prevalence of duodenal villous atrophy among patients of different ethnicities throughout the United States (US). Methods We performed a cross-sectional study of all patients who had duodenal biopsies submitted to a national pathology laboratory between January 2, 2008 and April 30, 2015. The prevalence of villous atrophy was calculated for the following ethnicities, using a previously published algorithm based on patient names: North Indian, South Indian, East Asian, Hispanic, Middle Eastern, Jewish, and other Americans. Results Among all patients (n=454,885), the median age was 53 years and 66% were female. The overall prevalence of celiac disease was 1.74%. Compared to other Americans (n=380,163; celiac disease prevalence 1.83%), celiac disease prevalence was lower in patients of South Indian (n=177, 0%; P=.08), East Asian (n=4700, 0.15%; P=<.0001), and Hispanic (n=31,491, 1.06%; P=<.0001) ethnicities. Celiac disease was more common in patients from the Punjab region (n=617, 3.08%) than in others from North India (n=1195, 1.51%; P=.02). The prevalence of celiac disease among patients of Jewish (n=17,806, 1.80%; P=.78) and Middle Eastern (n=1903, 1.52%; P=.33) ethnicities was similar to that of other Americans. Among Jewish individuals (n=17,806), the prevalence of celiac disease was 1.83% in Ashkenazi persons (n=16,440) and 1.39% in Sephardic persons (n=1366; P=.24). Conclusions Among patients undergoing duodenal biopsy, individuals from the Punjab region of India constitute the ethnic group in the US with the highest prevalence of villous atrophy consistent with celiac disease. Compared to other Americans, villous atrophy prevalence on duodenal biopsy is significantly lower among US residents of South Indian, East Asian, and Hispanic ancestry.

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Seroprevalence of celiac disease among United Arab Emirates healthy adult nationals: A gender disparity

Abstract: Compared to men the CD seroprevalence among women was remarkably higher. The CD association with women and chronic anemia is of importance from a public health perspective.

Cited by 25 publications

References 33 publications

Screening for Celiac Disease Using Anti-Tissue Transglutaminase Antibody Assays in Healthy Students Individuals

Screening for Celiac Disease Using Anti-Tissue Transglutaminase Antibody Assays in Healthy Students Individuals

Prevalence of celiac disease in Asia: A systematic review and meta‐analysis

Ethnic Variations in Duodenal Villous Atrophy Consistent With Celiac Disease in the United States

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