Seroprevalence of Borrelia IgG antibodies among individuals from Eastern Slovakia

Houžvičková, Andrea; Dorko, Erik; Rimárová, Kvetoslava; Diabelková, Jana; Drabiščák, Erik

doi:10.21101/cejph.a6808

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…A study where blood samples from tick-bitten individuals were collected from [2008][2009] showed that 43% of the Aland population had detectable Borrelia C6 IgG/IgM antibodies, which is higher than in Sweden; 35%. Furthermore, Borrelia IgG antibodies were detected in 23% of the Aland population, compared to 17% in Sweden and 4.2-13% in some other European countries [1,[5][6][7][8][9][10]. The seroprevalence of TBE-virus (TBEV) IgG antibodies is 0.4-5.3% in nearby geographical areas such as Norway and Sweden where TBE vaccination is still uncommon for the general population [11,12].…”

Section: Introductionmentioning

confidence: 99%

The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finland

et al. 2023

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The AxBioTick study was initiated to investigate the prevalence of ticks and tick-borne pathogens and their impact on antibody and clinical responses in tick-bitten individuals on the Aland Islands. This geographical area is hyperendemic for both Lyme borreliosis (LB) and Tick-borne encephalitis (TBE). Blood samples and ticks were collected from 100 tick-bitten volunteers. A total of 425 ticks was collected, all determined to Ixodes ricinus using molecular tools. Of them 20% contained Borrelia species, of which B. garinii and B. afzelii were most common. None contained the TBE virus (TBEV). Blood samples were drawn in conjunction with the tick bite, and eight weeks later. Sera were analyzed for Borrelia- and TBEV-specific antibodies using an ELISA and a semiquantitative antibody assay. In total 14% seroconverted in Borrelia C6IgG1, 3% in TBEV IgG, and 2% in TBEV IgM. Five participants developed clinical manifestations of LB. The high seroprevalence of both Borrelia (57%) and TBEV (52%) antibodies are likely attributed to the endemic status of the corresponding infections as well as the TBE vaccination program. Despite the similar prevalence of Borrelia spp. detected in ticks in other parts of Europe, the infection rate in this population is high. The AxBioTick study is continuing to investigate more participants and ticks for co-infections, and to characterize the dermal immune response following a tick bite.

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Section: Introductionmentioning

confidence: 99%

The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finland

et al. 2023

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Borrelia burgdorferi infections in children and adolescents in Switzerland – a seroprevalence study 2023/2024 (BOBUINCA)

Heeb,

Fritschi,

Marten

et al. 2024

Infection

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Background Lyme borreliosis is one of the most prevalent tick-borne diseases in Europe. Studies on seroprevalence of Borrelia burgdorferi IgG antibodies in children are rare. The aim of this study was to determine the seroprevalence of B. burgdorferi IgG antibodies in children and adolescents residing in North-Western Switzerland and neighbouring countries. Methods Prospective cross-sectional observational single-centre study using left-over plasma of asymptomatic paediatric patients. Included were children aged 1–17 years living in North-Western Switzerland and bordering areas of France and Germany. Excluded were children with symptoms of Lyme borreliosis or a chronic disease possibly affecting plasma antibodies (immunodeficiency syndrome, systemic lupus erythematosus) or with such medication (e.g., intravenous immunoglobuline treatment, allogenic stem cell transplantation, immunosuppressive treatment) as well as refugees seeking asylum. IgG antibodies against B. burgdorferi were measured by ELISA and positive or borderline results by line blot. Positivity was defined as scenario 1: ELISA positive/line blot positive or borderline OR ELISA borderline/line blot positive. Scenario 2: ELISA positive or borderline/line blot positive. A multivariable logistic regression model for seropositivity was applied. Results 962 children were included (mean age 9.63 years, standard deviation 5.01, 54.5% males). Seroprevalence for scenario 1 was 13.3% (95% CI: 11.2–15.6) and for scenario 2 11.2% (95% CI: 9.3–13.4). Seroprevalence (scenario 1) was comparable for age groups, sex and rural versus urban residence. Conclusion This study shows an increased seroprevalence for B. burgdorferi in the paediatric age compared to previous childhood studies. We also found an increased risk for B. burgdorferi infection at young age.

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Knowledge, attitudes and behaviour towards ticks and tick-borne diseases—A survey among Lyme borreliosis cases in Bavaria in 2019

Böhm,

Fingerle,

Beyerlein

et al. 2025

Ticks and Tick-borne Diseases

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Seroprevalence of Borrelia IgG antibodies among individuals from Eastern Slovakia

Cited by 3 publications

References 25 publications

The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finland

The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finland

Borrelia burgdorferi infections in children and adolescents in Switzerland – a seroprevalence study 2023/2024 (BOBUINCA)

Knowledge, attitudes and behaviour towards ticks and tick-borne diseases—A survey among Lyme borreliosis cases in Bavaria in 2019

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