Seroprevalence of Borrelia burgdorferi in North Eastern India

Praharaj, Ashok Kumar; Jetley, Sujata; Kalghatgi, AT

doi:10.1016/s0377-1237(08)80140-2

Cited by 27 publications

(16 citation statements)

References 13 publications

(11 reference statements)

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“…17.8%) [16] and Mongolia (1.9% -14.0%) [17]. It was, however, lower in comparison to the seroprevalence studies conducted in selected-populations from Poland [18] and Sweden [19] where anti-B.…”

Section: Discussionmentioning

confidence: 71%

Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia

Khor

Hassan

Mohd-Rahim

et al. 2019

J Infect Dev Ctries

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Introduction: Lyme disease has been well-described in the North America and European countries. However, information is still very limited in the developing countries including Malaysia. The Orang Asli (OA), the indigenous people of Peninsular Malaysia reside mostly in the forest and forest fringe areas abundant with the vector for Lyme disease. Here, we described the seroprevalence of Borellia burgdorferi (B. burgdorferi) among the OA and demographic variables that could be associated with seroprevalence. Methodology: A total of 16 OA villages distributed across 8 states in Peninsular Malaysia participated in this study. Sera obtained from 904 OA volunteers were screened for anti-B. burgdorferi IgG antibodies. ELISA results obtained and demographic information collected were analysed to identify possible variables associated with seroprevalence. Results: A total of 73 (8.1%) OA tested positive for anti-B. burgdorferi IgG antibodies. Among all the variables examined, village of residence (p = 0.045) was the only significant predictor for seropositivity. High (> 10.0%) prevalence was associated with three OA villages. Those living in one particular village were 1.65 times more likely to be seropositive as compared to other OA villages. Age, gender, marital status, household size, level of education, monthly household income and occupation were not significant predictors for seropositivity. Conclusion: Results of the present study support earlier findings that B. burgdorferi infection among Malaysians is currently under-recognized. Further studies will be needed at these locations to confirm the presence of Lyme disease among these populations.

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Section: Discussionmentioning

confidence: 71%

Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia

Khor

Hassan

Mohd-Rahim

et al. 2019

J Infect Dev Ctries

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“…A review of various cases/studies from the country is summarized in Table 1. [78910111213] The patient in the present case had both the characteristic centrifugally spreading lesion of ECM as well as other atypical lesions in the form of lymphangitic streaks, petechiae, and maculopapular lesions. This case report highlights the possibility of future risk of Lyme disease in Himachal Pradesh and warrants the treating physicians to be aware of its occurrence in this part of the world.…”

Section: Discussionmentioning

confidence: 77%

Lyme disease: A case report with typical and atypical lesions

Sharma¹,

Guleria²,

Sharma³

et al. 2017

Indian Dermatol Online J

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Lyme disease is a multisystem infectious disease caused by the spirochete “Borrelia burgdorferi,” which is transmitted by “Ixodes” tick, with skin being the most common and earliest organ to be affected. Diagnosis of erythema chronicum migrans (ECM), which is the characteristic lesion of early disease, may help in early treatment and prevention of complications. Here, we are reporting a case of Lyme disease in a 10-year-old young boy from a non-endemic zone of Himachal Pradesh, who presented with typical as well as atypical ECM lesions. The clinical diagnosis was confirmed serologically, and the child was treated successfully with doxycycline.

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“…[9] A study of 500 people from the northeastern states of India was done by Praharaj et al to assess the seroprevalence of Borrelial antibodies; 13% of the population was seropositive to IgG antibody detected by a commercial ELISA kit (NovaTech, Germany). [10] Recently, an outbreak of Lyme borreliosis in Wayanad district, Kerala, South India was reported in the lay press. Health officials believed that the vector was deer ticks.…”

Section: Discussionmentioning

confidence: 99%

Lyme disease in Haryana, India

Jairath¹,

Sehrawat²,

Jindal³

et al. 2014

Indian J Dermatol Venereol Leprol

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Lyme disease is a multiorgan animal-borne disease caused by the spirochete Borrelia burgdorferi. This case series highlights its presence in Haryana, a nonendemic zone. The first case was a 27-year-old housewife who presented with an annular erythematous patch with a central papule following an insect bite on the left upper arm. The second case was a 32-year-old farmer who gave a history of insect bite on the right arm followed by the development of an erythematous patch with a central blister. The third case, a 17-year-old boy presented with a history of tick bite over right thigh and a typical bull's eye lesion with central ulceration. These cases were managed with oral doxycycline 100 mg twice daily for 14 days. The fourth case was a 7-year-old boy with typical erythema migrans on the right check and neck while the fifth case, a 30-year-old housewife, presented with an erythematous patch with a central papule on the right buttock. These patients were treated with oral amoxycillin 25 mg/kg, thrice daily for 14 days. All patients showed IgM antibodies to B. burgdorferi. Treatment led to clearance of lesions in all the patients. Lyme borreliosis was diagnosed in these patients based on the history of established exposure to tick bites, presence of classic signs and symptoms, serology and the response to treatment.

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Seroprevalence of Borrelia burgdorferi in North Eastern India

Abstract: Seropositivity to B burgdorferi suggests infection by the organism and presence of Lyme disease in these areas. Further population and vector biology studies are required to find out the exact species involved in transmission of the organism.

Cited by 27 publications

References 13 publications

Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia

Seroprevalence of Borrelia burgdorferi among the indigenous people (Orang Asli) of Peninsular Malaysia

Lyme disease: A case report with typical and atypical lesions

Lyme disease in Haryana, India

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