Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study

Torzsa, Péter; Devadiga, Raghavendra; Tafalla, Mónica

doi:10.1186/s12879-017-2356-2

Cited by 13 publications

(15 citation statements)

References 33 publications

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“…We also demonstrated that female sex significantly correlated with lower pertussis immunity and lower than median pertussis titers. This finding agrees with a study that found a correlation between reduced seropositivity for pertussis toxin and female sex in Hungary [45]. Sex differences in vaccine response occur for a variety of antigens although no clear pattern has been identified [46, 47].…”

Section: Discussionsupporting

confidence: 90%

Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects

et al. 2019

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Background The antibody response to pertussis vaccination in rheumatoid arthritis is unknown, a concerning omission given the relatively low efficacy of the pertussis vaccine, a rise in pertussis infections, and a general increased susceptibility to infection in rheumatoid arthritis. Additionally, the contributions from an intrinsically dysregulated immune system in rheumatoid arthritis and immune-suppressing medications to the response to pertussis vaccination is poorly defined. This study examines antibody titers against pertussis in vaccinated rheumatoid arthritis patients and controls as well as evaluates potential contributions from demographic factors, immune suppressing medications, and reactivity against citrullinated pertussis. Methods Serum IgG titers against native and citrullinated pertussis and tetanus were quantified by enzyme-linked immunosorbent assay in rheumatoid arthritis subjects and controls who were vaccinated within 10 years. Titers were compared by t-test and percent immunity by Fisher’s exact test. Multivariable logistic regression was used to identify clinical factors that correlate with native pertussis titers. Results Compared to controls, rheumatoid arthritis subjects had lower titers against pertussis, but not tetanus, and reduced immunity to pertussis. These results were even more prominent at 5–10 years post-vaccination, when rheumatoid arthritis patients had 50% lower titers than controls and 2.5x more rheumatoid arthritis subjects were not considered immune to pertussis. Multiple logistic regression demonstrated that female sex and methotrexate use, but not TNF inhibiting medications, correlated with reduced immunity to pertussis. Finally, rheumatoid arthritis patients had higher IgG titers against citrullinated pertussis than native pertussis. Conclusions Pertussis titers are lower in vaccinated rheumatoid arthritis patients with evidence for contributions from female sex, a citrulline-biased immune response, and methotrexate use.

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Section: Discussionsupporting

confidence: 90%

Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects

et al. 2019

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“…The determination of age associated antibody levels against B. pertussis is important in deciding the target age group for booster vaccination as well as for the study of disease epidemiology [15]. Our results suggest that a recent pertussis infection or reinfection after waning immunity exists among young or future parents, as well as among other elderly family members, similar to other authors' findings [7,15,17,18]. In our research, we found that anti-PT IgG levels ≥ 125 IU/mL were registered among three subjects (two men and one woman) aged over 60 years.…”

Section: Discussionsupporting

confidence: 88%

“…Our findings recognized adults as the reservoirs of infection for pertussis for transmission to vulnerable infants, the new vaccination strategies in adults, such as the "cocooning strategy" and maternal immunization during the last trimester of pregnancy, or universal immunization may be considered [18,26,27,28].…”

Section: Discussionmentioning

confidence: 79%

Seroprevalence of pertussis in adult population

2018

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Introduction/Objective Seroepidemiological studies are crucial for better understanding of pertussis epidemiology. The aim of this study was to assess the seroprevalence of anti-Bordetella pertussis toxin antibodies (anti-PT IgG) in the adult population of Novi Sad, and to evaluate the differences by age and sex. Methods A cross-sectional study was conducted in 468 healthy adults aged ≥ 20 years stratified into seven age groups. The youngest of our participants received the last dose of the vaccine at least 18 years ago. Positive results of anti-PT IgG concentrations were considered a consequence of natural pertussis infection or reinfection. A commercial ELISA kit (Euroimmun®, Lübeck, Germany), with anti-PT IgG with four calibrators (5 IU/mL, 25 IU/mL, 100 IU/mL, and 200 IU/mL) was used. Results Most of the subjects (53.8%) had anti-PT IgG of > 5 to < 62.5 IU/mL. The proportion of participants with high concentrations (62.5 to < 125 IU/mL) was statistically significantly higher in females than in males (5.4% vs. 0.4%, p = 0.002). The highest values of anti-PT IgG were detected among subjects in the age group of 20-24 years (17.5 ± 22.2 IU/mL), and in the participants ≥ 60 years of age (15.0 ± 29.4 IU/ mL). The percentage of anti-PT IgG concentration of ≥ 62.5 IU/mL was the highest among subjects aged ≥ 60 years (6.6%) and among those aged 20-24 years (5%). Conclusions The limited duration of vaccine-induced immunity with subsequent infection or reinfection enables the circulation of pertussis in the adult population of Novi Sad that serves as the reservoir of infection for transmission to vulnerable persons.

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“…12 Adolescents and adults are identified as the primary source of infection for newborns and young infants. 13 It is, therefore, of great importance to prevent and early detect pertussis among those populations. 4 The waning of immunity following pertussis vaccination and lack of administration of booster doses in addition to challenges related to the diagnosis can contribute to the persistence of pertussis.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional seroprevalence study of antibody to Bordetella pertussis toxin in western Saudi Arabia: is there a need for a vaccine booster dose for adolescents and young adults?

et al. 2021

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ObjectivesThe present study was conducted to estimate the seroprevalence of antibody to pertussis toxin among adult populations in western Saudi Arabia.DesignA cross-sectional study.SettingKing Abdulaziz Medical City, Jeddah, western Saudi Arabia. A tertiary care teaching hospital.ParticipantsA total of 1200 participants (400 healthcare workers, 400 military recruits and 400 blood donors) were included. The majority were male (79.3%), and the mean (±SD) age was 27.2 (±6.7) years old.InterventionsThe study included the analysis of serum blood samples using commercial ELISA. A consecutive sampling technique was applied.Primary outcome measuresSeropositivity of antipertussis toxin immunoglobulin G (anti-PT IgG) ≥62.5 IU/mL.ResultsAntibody titres ≥62.5 IU/mL, indicating exposure to Bordetella pertussis infection within the last year, were identified in 12.0% (95% CI 10.2% to 14.0%) of the participants. Titres ≥125 IU/mL, suggesting recent infection, were detected in 3.5% (95% CI 2.5% to 4.7%). Seroprevalence of positive IgG antibody titres (≥62.5 IU/mL) was highest among the healthcare workers (HCWs) (14%), then the military recruits (13.5%) and blood donors (8.5%; p=0.03). The multivariate regression analysis showed association between participants group (HCWs and military), male gender and younger age (<25 years old) and higher antibody to pertussis toxin.ConclusionsHigh pertussis seropositivity was associated with participants’ occupation (ie, healthcare workers and military recruits), and anti-PT IgG titre was negatively correlated with age. A substantial deficiency in pertussis reporting in Saudi Arabia has been suggested, with potential increased risk to the most vulnerable populations (ie, infants and elderly). Enhancing the booster dose of pertussis vaccine for adolescents and adults is crucial to minimise the burden of pertussis.

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Seroprevalence of Bordetella pertussis antibodies in adults in Hungary: results of an epidemiological cross-sectional study

Cited by 13 publications

References 33 publications

Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects

Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects

Seroprevalence of pertussis in adult population

Cross-sectional seroprevalence study of antibody to Bordetella pertussis toxin in western Saudi Arabia: is there a need for a vaccine booster dose for adolescents and young adults?

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