Seroprevalence of Asymptomatic Dengue Virus Infection and Its Antibodies Among Healthy/Eligible Saudi Blood Donors: Findings From Holy Makkah City

Ashshi, Ahmed Mohamed; Alghamdi, Saad; El-Shemi, Adel Galal; Almdani, Sabir; Refaat, Bassem; Am, Mohamed; Ghazi, Hani; Azhar, Esam I.; Al‐Allaf, Faisal A.

doi:10.1177/1178122x17691261

Cited by 12 publications

(18 citation statements)

References 41 publications

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“…This result is consistent with that found by Ashshi et al . (100%) in the studies conducted in Saudi Arabia involving eligible blood donors [ 28 ]. Blood donors in Saudi Arabia are essentially male because of their culture.…”

Section: Discussionmentioning

confidence: 99%

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Dengue virus serological markers among potential blood donors: an evidence of asymptomatic dengue virus transmission in Cameroon

Tchuandom¹,

Lissom²,

Ateba³

et al. 2020

Pan Afr Med J

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Introduction the risk of dengue virus or its antibodies which can be transmitted through blood transfusion by asymptomatic individuals infected, has been a major concern all over the world. Dengue is an endemic disease in sub-Saharan Africa, particularly in Cameroon. The purpose of this study is to determine the frequency of dengue virus (DENV) infection among potential blood donors at Yaounde Jamot Hospital. Methods serum samples were collected from 310 potential adult blood donors aged 18-57 years, who signed a written informed consent and completed the questionnaire between March 2019 and August 2019. This serum is used to screen for the presence of serological markers of DENV infection (NS1, IgM and IgG) using immunochromatographic tests (Zhuhai Encode Medical Engineering Co., Ltd, China). IgM/IgG positive samples were confirmed by enzyme-linked immunosorbent assays (ELISA). Results the overall prevalence was 24.8% among potential blood donors were subdivided as follows: 4.5% (14/310), 12.3% (38/310) and 6.1% (19/310) showed mono-positivity to DENV-NS1 antigen, anti-DENV IgM and anti-DENV IgG antibodies respectively. 1.9% (6/310) of potential blood donors showed dual positivity to anti-DENV IgM antibodies and anti-DENV IgG antibodies. The presence of DENV-NS1 antigen show asymptomatic viremia of dengue at the time of donation, while the presence of IgG antibodies reflects the high endemicity of dengue disease in the city of Yaoundé. Conclusion these findings demonstrate the high level of risk of the DENV transmission among potential blood donors to needy recipients, underscoring the importance of establishing dengue fever blood screening in different services and blood collection units in Cameroon to improve safety transfusion and control the dissemination of the DENV.

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Section: Discussionmentioning

confidence: 99%

“…This value is similar to findings found by Ashshi et al . in Saudi Arabia that showed a 5.3% incidence of DENV-NS1 antigen in eligible blood donors [ 28 ]. However, this is inconsistent with the results found by Kulkarni et al .…”

Section: Discussionmentioning

confidence: 99%

Dengue virus serological markers among potential blood donors: an evidence of asymptomatic dengue virus transmission in Cameroon

Tchuandom¹,

Lissom²,

Ateba³

et al. 2020

Pan Afr Med J

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show abstract

“…More important, anti‐DENV antibody‐positive individuals infected with a different serotype can cause secondary infections with severe outcome. In view of the large proportion (53–87%) of subclinical infections, the possibility of transfusion‐associated dengue (TAD) was evaluated in different countries . In fact, cases of TAD have been documented …”

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confidence: 99%

Risk of transfusion‐associated dengue: screening of blood donors from Pune, western India

et al. 2018

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BACKGROUND: Dengue, a mosquito-borne viral disease, is endemic in >125 countries worldwide. The threat of blood-borne transmission of dengue virus (DENV) has been documented. STUDY DESIGN AND METHODS:This study was conducted to assess the potential magnitude of transfusion-associated dengue, by determination of DENV seromarkers in blood donations from Pune, India, during two dengue seasons (2016 and 2017). These included DENV nonstructural protein 1 (NS1), anti-DENV immunoglobulin (Ig) M, anti-DENV IgG (enzyme-linked immunosorbent assay), and DENV RNA (reverse transcription-polymerase chain reaction).RESULTS: NS1 (IgM) reactivity was 1 of 209, 0.48% (11/209, 5.3%) in 2016 and 2 of 311, 0.64% (20/311, 6.4%) in 2017. Of the 34 NS1/IgM reactives, 1 NS1-reactive donor and 10 IgM-reactive donors exhibited evidence of secondary infection. DENV RNA was not detected in any of the 34 NS1/IgM reactives. Among the NS1/IgM negatives, anti-DENV IgG reactivity was high in 2016 (75%) and further increased in 2017 (87%, p = 0.002). CONCLUSION:Although RNA negative, detection of 34 NS1/IgM-reactive donations, of which 11 had evidence of secondary infection, suggests the need for further evaluation on the basis of potential risk to recipients of either dengue transmission or increased risk of secondary infection. These would include multicenter studies followed by cost-benefit analyses. ABBREVIATIONS: DENV = dengue virus; ELISA = enzyme-linked immunosorbent assay; Ig = immunoglobulin; PMC = Pune Municipal Corporation; RT-PCR = reverse transcription-polymerase chain reaction; TAD = transfusion-associated dengue From the

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“…Globalization and the rapid urbanization of our growing cities expose people to mosquito bites which transmit the dengue virus [ 1 , 2 ]. Dengue fever is a public health issue in the subtropical and tropical regions [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Dengue virus infection and pregnancy outcomes during the 2017 outbreak in Ouagadougou, Burkina Faso: A retrospective cohort study

Tougma

Zoungrana²,

Yaméogo

et al. 2020

PLoS ONE

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Introduction Dengue fever is a re-emerging pathology in Burkina Faso. It affects everyone and pregnant women are not left out. The objective of this study was to estimate the burden of dengue fever and to assess its effects on pregnancy outcomes in hospitalized pregnant women during the 2017 outbreak in Ouagadougou, Burkina Faso. Method This was a retrospective cohort study including febrile pregnant women from five health facilities in Ouagadougou. The study was carried out from July 1st to December 31st, 2017. A logistic stepwise regression was performed to identify the pregnancy adverse outcomes risk factors. Results Our study included 424 pregnant women at a mean age of 27.1 years old (Standard deviation: 6.23 years). Overall 28.54% (121/424) were infected with dengue virus. During followup, 29.01% (123/424) presented an adverse pregnancy outcome. Adjusted for gestational age and clinical symptoms, the risk of adverse pregnancy outcome was twice as high among dengue infected women as compared to uninfected women with an adjusted Odds Ratio (aOR) = 2.09 (1.08-4.05). The risk of the adverse pregnancy outcome was higher in the third trimester of pregnancy with aOR = 1.66 (1.02-2.72) in dengue fever infected women.

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Seroprevalence of Asymptomatic Dengue Virus Infection and Its Antibodies Among Healthy/Eligible Saudi Blood Donors: Findings From Holy Makkah City

Cited by 12 publications

References 41 publications

Dengue virus serological markers among potential blood donors: an evidence of asymptomatic dengue virus transmission in Cameroon

Dengue virus serological markers among potential blood donors: an evidence of asymptomatic dengue virus transmission in Cameroon

Risk of transfusion‐associated dengue: screening of blood donors from Pune, western India

Dengue virus infection and pregnancy outcomes during the 2017 outbreak in Ouagadougou, Burkina Faso: A retrospective cohort study

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