Seroprevalence of antibodies to legionella pneumophila in hemodialysis patients

Öngüt, Gözde; Yavuz, Alpaslan; Öğünç, Dilara; Tuncer, Murat; Öztürk, Feridun; Mutlu, Derya; Dönmez, Levent; Çolak, Dilek; Ersoy, Figen; Yakupoğlu, G; Gültekin, Meral

doi:10.1016/j.transproceed.2003.11.061

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Also analysed were the various risk factors for infection by L. pneumophila. There was no statistically significant difference between L. pneumophila seropositivity and the potential risk factors [7]. In another study, Morimoto concluded that the titer in hemodialysis patients was higher than in the control group (p less than 0.005) [22].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Legionella antibodies in immunocompromised patients

et al. 2013

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Section: Discussionmentioning

confidence: 99%

“…Patients with chronic renal failure and patients post-organ transplantation are deemed high-risk groups. Other factors associated with the development of Legionnaires' disease include old age, cancer and alcohol intake [3,7].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Legionella antibodies in immunocompromised patients

et al. 2013

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“…The data collected from literature shows the prevalence of anti-L. pneumophila antibodies in the hemodialysis patients amounts to 5.16%, whereas in patients after renal transplantation about 25% (Mazieri et al, 1994;Ongut et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cytokine Release Afterin VitroStimulation of Whole Blood withLegionella Pneumophilain Immunocompromised Patients

Sikora

Kozioł-Montewka

Książek

et al. 2012

Immunological Investigations

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This study we examined ex vivo potential of the immune response after stimulation of whole blood with L. pneumophila SG 1, SG 2-14 and L. pneumophila standard strain ATCC 33152 in immunocompromised patients, such as: hemodialysis patients and patients after renal transplantation. The levels of TNF-α and IFN-γ in supernatants were measured with the use of commercial ELISA kits. The synthesis of TNF-α and IFN-γ after stimulation with L. pneumophila were analyzed in two aspects: differentiated stimulatory activity in relation to SG 1, SG 2-14 and ATCC 33152 L. pneumophila and differentiated response of the hemodialysis patients and patients after renal transplantation in relation to the control group. The positive and negative results of anti-L. pneumophila antibodies of two groups of our patients were found for the analysis of the stimulatory activity of L.pneumophila as a primary or secondary response. In patients with immunosuppression the response in the secretion of cytokines (TNF-α and IFN-γ) was reduced after stimulation of L. pneumophila SG 1 but in varying degrees after stimulation of L. pneumophila SG 2-14, which indicates that the risk of the infection is varied.

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Review Global seroprevalence of legionellosis - a systematic review and meta-analysis

Graham

Hales

White³

et al. 2020

Sci Rep

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Legionella is a ubiquitous pathogen yet the global occurrence of legionellosis is poorly understood. To address this deficit, this paper summarises the available evidence on the seroprevalence of Legionella antibodies and explores factors that may influence seroprevalence estimates. Through a systematic review, a total of 3979 studies were identified with seroprevalence results published after 1 January 1990. We tabulated findings by World Health Organization (WHO) region, location, study period and design, composition of study population(s) for all ages in terms of exposure, sex, detection methods, IFA titre, Legionella species measured, and present seroprevalence point estimates and 95% confidence intervals. Sampled populations were classified according to income, WHO region, gender, age, occupation and publication date. We conducted a meta-analysis on these subgroups using Comprehensive Meta-Analysis 3.0 software. Heterogeneity across studies was evaluated by the Q test in conjunction with I2 statistics. Publication bias was evaluated via funnel plot and Egger’s test. Fifty-seven studies met our inclusion criteria, giving an overall estimate of seroprevalence for Legionella of 13.7% (95% CI 11.3–16.5), but with substantial heterogeneity across studies.

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Seroprevalence of antibodies to legionella pneumophila in hemodialysis patients

Cited by 5 publications

References 8 publications

Prevalence of Legionella antibodies in immunocompromised patients

Prevalence of Legionella antibodies in immunocompromised patients

Assessment of Cytokine Release Afterin VitroStimulation of Whole Blood withLegionella Pneumophilain Immunocompromised Patients

Review Global seroprevalence of legionellosis - a systematic review and meta-analysis

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