Seroprevalence of antibodies to chlamydia pneumoniae in women with preeclampsia

Terán, Enrique; Escudero, Carlos; Calle, Andrés; Ness, Roberta B.; Roberts, James M.; Heine, Phillip

doi:10.1016/s0029-7844(03)00473-3

Cited by 14 publications

(6 citation statements)

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“…In addition, Goulis and colleagues (16) showed that women with history of preeclampsia had higher titres of all classes of C. pneumoniae antibodies than women with previous normotensive pregnancy. However, in our study as well as in two others, C. pneumoniae antibodies were not more common in women with preeclampsia than in women with normal pregnancies (17,18). The application of highly sensitive assays (hsCRP) for the measurement of slightly elevated CRP levels has changed our view of the role of CRP as a marker of acute infection and tissue injury.…”

Section: Discussioncontrasting

confidence: 51%

“…pneumoniae infection has been linked to essential hypertension (13,14), and a few reports on the association of C. pneumoniae antibodies with preeclampsia have also been published. The results on the presence of elevated C. pneumoniae antibody levels in preeclampsia have been contradictory (15)(16)(17)(18). In addition, both elevated cytomegalovirus and C. pneumoniae antibodies have been detected in women with early onset preeclampsia (6).…”

Section: Introductionmentioning

confidence: 99%

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Maternal SerumChlamydia PneumoniaeAntibodies and CRP Levels in Women with Preeclampsia and Gestational Hypertension

Karinen

Leinonen²,

Bloigu³

et al. 2008

Hypertension in Pregnancy

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Maternal SerumChlamydia PneumoniaeAntibodies and CRP Levels in Women with Preeclampsia and Gestational Hypertension

Karinen

Leinonen²,

Bloigu³

et al. 2008

Hypertension in Pregnancy

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“…19 In a similar study, the odds ratio for the proportion of preeclamptic women (9 of 11) versus controls (52 of 73) with a positive C. pneumoniae titre was 1.8 (95% confidence interval 0.4-9.1). 20 Finally, in a recent study, the authors reported a trend for women with early-onset pre-eclampsia (<34 weeks of gestation) to have significantly higher levels of IgG antibodies to C. pneumoniae compared with women with late-onset pre-eclampsia (¼34 weeks of gestation), normotensive intrauterine growth retardation or normal pregnancy, but this was not statistically significant. 21 In our study, we have shown that women with a history of preeclampsia have higher titres of all classes of C. pneumoniae antibodies than women without a history of pre-eclampsia, whereas their total immunoglobulin levels remain unchanged.…”

Section: Discussionmentioning

confidence: 94%

“…18 C. pneumoniae infection causes similar changes in inflammatory markers to those seen in pre-eclampsia, and there has been one study that provided evidence for an association between preeclampsia and C. pneumoniae infection, 19 although another study did not confirm this. 20 One recent study reported a trend for increased levels of IgG antibodies against C. pneumoniae in early-onset pre-eclampsia, but this was not statistically significant. 21 In this study, all three classes of serum antibodies were detected: specific IgM indicating acute infection, specific IgG indicating past infection and specific IgA indicating chronic infection.…”

Section: Introductionmentioning

confidence: 94%

Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre‐eclampsia

Goulis

Chappell

Gibbs

et al. 2005

BJOG

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Objective To establish the prevalence of Chlamydia pneumoniae (C. pneumoniae) infection in a pregnant UK population and to investigate whether C. pneumoniae infection is more common in women with a previous history of pre-eclampsia. Design Prospective study.Setting Academic Hospital.Population Ninety-one pregnant women (54 parous and 37 nulliparous) at 16 -22 weeks of gestation were studied. Of the parous women, 32 had a previous history of pre-eclampsia. Methods Peripheral blood was drawn for C. pneumoniae antibodies between 16-22 and 28-40 weeks of gestation. C. pneumoniae antibodies were measured using a solid-phase enzyme immunoassay. According to pregnancy outcome, women were categorised into normal, gestational hypertension and pre-eclampsia groups. Main outcome measures Serum levels of IgG, IgA and IgM C. pneumoniae antibodies.Results Prevalence of seropositivity to C. pneumoniae was 77%. Parous women had significantly higher levels of IgA and IgM C. pneumoniae antibodies than nulliparous women (P < 0.04). Parous women with previous pre-eclampsia were found to have higher levels of antibodies than parous women with a normal obstetric history (P 0.003). There was no difference in the antibody levels in women with different pregnancy outcomes. Conclusions The longitudinal data do not indicate an association between C. pneumoniae infection and preeclampsia. However, the subgroup analysis of parous women demonstrated raised C. pneumoniae antibodies in the women with previous pre-eclampsia, and therefore suggests that there may be an association between C. pneumoniae and the disease in this group.

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“…The association of PE and maternal infection has been revealed by epidemiological studies showing elevated antibody titers for Chlamydia pneumonia and cytomegalovirus in patients with PE. [226][227][228][229][230] In vitro studies showed that with the binding of TLR3 by poly (I:C) or TLR4 by LPS, the cytokine secretion by trophoblast was significantly increased and subsequently lead to monocyte chemotaxis. 162,231,232 Poly (I:C) stimulation of TLR3 on trophoblast was also found to provoke the production of anti-angiogenic sFlt-1.…”

Section: Toll-like Receptorsmentioning

confidence: 99%

Innate Immunity, Decidual Cells, and Preeclampsia

2013

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Preeclampsia (PE) manifested by hypertension and proteinuria complicates 3% to 8% of pregnancies and is a leading cause of fetal-maternal morbidity and mortality worldwide. It may lead to intrauterine growth restriction, preterm delivery, and long-term sequelae in women and fetuses, and consequently cause socioeconomic burden to the affected families and society as a whole. Balanced immune responses are required for the maintenance of successful pregnancy. Although not a focus of most studies, decidual cells, the major resident cell type at the fetal-maternal interface, have been shown to modulate the local immune balance by interacting with other cell types, such as bone marrow derived-immune cells, endothelial cells, and invading extravillous trophoblasts. Accumulating evidence suggests that an imbalanced innate immunity, facilitated by decidual cells, plays an important role in the pathogenesis of PE. Thus, this review will discuss the role of innate immunity and the potential contribution of decidual cells in the pathogenesis of PE.

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Seroprevalence of antibodies to chlamydia pneumoniae in women with preeclampsia

Cited by 14 publications

References 0 publications

Maternal SerumChlamydia PneumoniaeAntibodies and CRP Levels in Women with Preeclampsia and Gestational Hypertension

Maternal SerumChlamydia PneumoniaeAntibodies and CRP Levels in Women with Preeclampsia and Gestational Hypertension

Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre‐eclampsia

Innate Immunity, Decidual Cells, and Preeclampsia

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