Seroprevalence of Antibodies against Seal Influenza A(H10N7) Virus in Harbor Seals and Gray Seals from the Netherlands

Bodewes, Rogier; García, Ana Rubio; Brasseur, S.M.J.M.; Conteras, Guillermo J. Sanchez; Bildt, Marco W. G. van de; Osterhaus, Albert D. M. E.; Kuiken, Thijs

doi:10.1371/journal.pone.0144899

Cited by 24 publications

(15 citation statements)

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“…Recently, an H10N7 virus was isolated from dead harbor seals in Denmark 12 . A novel reassortant H10N7 AIV was found in chickens in Eastern China 11 12 13 14 15 16 17 18 19 20 21 22 23 . Additionally, an H10N4 isolate caused an outbreak of respiratory disease in mink in Sweden 15 .…”

mentioning

confidence: 99%

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Zhang

et al. 2016

Sci Rep

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Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.

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confidence: 99%

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Zhang

et al. 2016

Sci Rep

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“…Given the spread of H10N7 through harbor seal colonies in the Kattegat, North, and Wadden Seas, AIV could infect all harbor seal colonies in Northern Europe. Antibodies to H10N7 were detected in grey seals (Halichoerus grypus) from Dutch waters (Bodewes et al 2015b), indicating that other sympatric marine mammal species may play a role in the epidemiology. Finally, infection of European marine mammals with novel AIV strains can be expected to occur again, and surveillance for AIV in marine mammals, coupled with further investigation of viral adaptation, pathology, epidemiology, and zoonotic potential of H10N7, are warranted.…”

Section: Seal Influenza Virus Infections By Aleksija Neimanismentioning

confidence: 99%

Recent Changes in Infectious Diseases in European Wildlife

Yon¹,

Duff

Ågren

et al. 2019

Journal of Wildlife Diseases

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Many infectious diseases originating from, or carried by, wildlife affect wildlife conservation and biodiversity, livestock health, or human health. We provide an update on changes in the epidemiology of 25 selected infectious, wildlife-related diseases in Europe (from 2010-16) that had an impact, or may have a future impact, on the health of wildlife, livestock, and humans. These pathogens were selected based on their: 1) identification in recent Europe-wide projects as important surveillance targets, 2) inclusion in European Union legislation as pathogens requiring obligatory surveillance, 3) presence in recent literature on wildlife-related diseases in Europe since 2010, 4) inclusion in key pathogen lists released by the Office International des Epizooties, 5) identification in conference presentations and informal discussions on a group email list by a European network of wildlife disease scientists from the European Wildlife Disease Association, or 6) identification as pathogens with changes in their epidemiology during 2010-16. The wildlife pathogens or diseases included in this review are: avian influenza virus, seal influenza virus, lagoviruses, rabies virus, bat lyssaviruses, filoviruses, canine distemper virus, morbilliviruses in aquatic mammals, bluetongue virus, West Nile virus, hantaviruses, Schmallenberg virus, Crimean-Congo hemorrhagic fever (CCHF) virus, African swine fever virus, amphibian ranavirus, hepatitis E virus, bovine tuberculosis (Mycobacterium bovis), tularemia (Francisella tularensis), brucellosis (Brucella spp.), salmonellosis (Salmonella spp.), Coxiella burnetii, chytridiomycosis, Echinococcus multilocularis, Leishmania infantum, and chronic wasting disease. Further work is needed to identify all of the key drivers of disease change and emergence, as they appear to be influencing the incidence and spread of these pathogens in Europe. We present a summary of these recent changes during 2010-16 to discuss possible commonalities and drivers of disease change and to identify directions for future work on wildlife-related diseases in Europe. Many of the pathogens are entering Europe from other continents while others are expanding their ranges inside and beyond Europe. Surveillance for these wildlife-related diseases at a continental scale is therefore important for planet-wide assessment, awareness of, and preparedness for the risks they may pose to wildlife, domestic animal, and human health.

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“…In 2014, high mortality of harbor seals ( Phoca vitulina ) in northwestern Europe was associated with infection by H10N7 influenza virus [ 18 , 19 , 20 , 21 , 22 ]. The virus was first reported in seals in Sweden and Denmark, and subsequently spread to seals off the coasts of Germany and the Netherlands [ 23 ]. Although the virus had the capacity to replicate in the mammalian respiratory tract, e.g., in ferrets, the observed high mortality was most likely due to secondary bacterial infections [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Mutations in the Hemagglutinin of H10N7 Viruses Isolated from Seals on Virus Replication in Avian and Human Cells

Dittrich

Scheibner

Salaheldin

et al. 2018

Viruses

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Wild birds are the reservoir for low-pathogenic avian influenza viruses, which are frequently transmitted to domestic birds and occasionally to mammals. In 2014, an H10N7 virus caused severe mortality in harbor seals in northeastern Europe. Although the hemagglutinin (HA) of this virus was closely related to H10 of avian H10N4 virus, it possessed unique nonsynonymous mutations, particularly in the HA1 subunit in or adjacent to the receptor binding domain and proteolytic cleavage site. Here, the impact of these mutations on virus replication was studied in vitro. Using reverse genetics, an avian H10N4 virus was cloned, and nine recombinant viruses carrying one of eight unique mutations or the complete HA from the seal virus were rescued. Receptor binding affinity, replication in avian and mammalian cell cultures, cell-to-cell spread, and HA cleavability of these recombinant viruses were studied. Results show that wild-type recombinant H10N4 virus has high affinity to avian-type sialic acid receptors and no affinity to mammalian-type receptors. The H10N7 virus exhibits dual receptor binding affinity. Interestingly, Q220L (H10 numbering) in the rim of the receptor binding pocket increased the affinity of the H10N4 virus to mammal-type receptors and completely abolished the affinity to avian-type receptors. No remarkable differences in cell-to-cell spread or HA cleavability were observed. All viruses, including the wild-type H10N7 virus, replicated at higher levels in chicken cells than in human cells. These results indicate that H10N7 acquired adaptive mutations (e.g., Q220L) to enhance replication in mammals and retained replication efficiency in the original avian host.

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Seroprevalence of Antibodies against Seal Influenza A(H10N7) Virus in Harbor Seals and Gray Seals from the Netherlands

Cited by 24 publications

References 15 publications

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

Recent Changes in Infectious Diseases in European Wildlife

Impact of Mutations in the Hemagglutinin of H10N7 Viruses Isolated from Seals on Virus Replication in Avian and Human Cells

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