Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan

Tanaka, Akihito; Yamamoto, Shohei; Miyo, Kengo; Mizoue, Tetsuya; Maeda, Kenji; Sugiura, Wataru; Mitsuya, Hiroaki; Sugiyama, Haruhito; Ohmagari, Norio

doi:10.1016/j.jinf.2021.01.010

Cited by 24 publications

(20 citation statements)

References 8 publications

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“…We confirmed that the breakthrough cases occurred independently in different timings and departments, showing no evidence of clustered infection in the hospital. This finding is consistent with our previous reports from the first and second serological surveys in NCGM before the vaccination program, 12,13 suggesting that infection among the staff had occurred mainly outside the hospital (household, community, etc.). NCGM has adopted comprehensive measures against nosocomial infection since the early phase of the epidemic.…”

Section: Discussionsupporting

confidence: 93%

COVID-19 breakthrough infections and pre-infection neutralizing antibody

Yamamoto

Maeda

Matsuda

et al. 2021

Preprint

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Background: While increasing coverage of effective vaccines against coronavirus disease 2019 (COVID–19), emergent variants raise concerns about breakthrough infections. Data are limited, however, whether breakthrough infection during the epidemic of the variant is ascribed to insufficient vaccine–induced immunogenicity. Methods: We described incident COVID–19 in relation to the vaccination program among workers of a referral hospital in Tokyo. During the predominantly Delta epidemic, we followed 2,473 fully vaccinated staff (BNT162b2) for breakthrough infection and selected three matched controls. We measured pre–infection neutralizing antibodies against the wild-type, Alpha (B.1.1.7), and Delta (B.1.617.2) strains using live viruses and anti–spike antibodies using quantitative assays, and compared them using the generalized estimating equation model between the two groups. Results: No COVID–19 cases occurred 1–2 months after the vaccination program during the fourth epidemic wave in Japan, dominated by the Alpha variant, while 22 cases emerged 2–4 months after the vaccination program during the fifth wave, dominated by the Delta variant. In the vaccinated cohort, all 17 cases of breakthrough infection were mild or asymptomatic and had returned to work early. There was no measurable difference between cases and controls in pre–infection neutralizing antibody titers against the wild–type, Alpha, and Delta, and anti–spike antibody titers, while neutralizing titers against the variants were considerably lower than those against the wild–type. Conclusions: Pre–infection neutralizing antibody titers were not decreased among patients with breakthrough infection under the Delta variant rampage. The result points to the importance of infection control measures in the post–vaccination era, irrespective of immunogenicity profile.

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Section: Discussionsupporting

confidence: 93%

COVID-19 breakthrough infections and pre-infection neutralizing antibody

Yamamoto

Maeda

Matsuda

et al. 2021

Preprint

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“…Low seroprevalence in the general population in Lao PDR, 2020 is similar to studies from other countries in southeast Asia where COVID-19 cases were low [30] and in contrast to high incidence countries [31] . Healthcare workers are particularly at risk of infection and our data showing low seroprevalence are again in agreement with studies from countries with low reported COVID-19 cases [32] , [33] , [34] , and in contrast to higher seroprevalence in countries with higher incidence of confirmed COVID-19 cases, including in East Asia [35] .…”

Section: Discussionsupporting

confidence: 92%

Low seroprevalence of COVID-19 in Lao PDR, late 2020

Virachith¹,

Pommelet²,

Calvez³

et al. 2021

The Lancet Regional Health - Western Pacific

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Background In 2020 Lao PDR had low reported COVID-19 cases but it was unclear whether this masked silent transmission. A seroprevalence study was done August - September 2020 to determine SARS-CoV-2 exposure. Methods Participants were from the general community (n=2433) or healthcare workers (n=666) in five provinces and bat/wildlife contacts (n=74) were from Vientiane province. ELISAs detected anti- SARS-CoV-2 Nucleoprotein (N; n=3173 tested) and Spike (S; n=1417 tested) antibodies. Double-positive samples were checked by IgM/IgG rapid tests. Controls were confirmed COVID-19 cases (n=15) and pre-COVID-19 samples (n=265). Seroprevalence for the general community was weighted to account for complex survey sample design, age and sex. Findings In pre-COVID-19 samples, 5·3%, [95% CI=3·1-8·7%] were anti-N antibody single-positive and 1·1% [0·3-3·5%] were anti-S antibody single positive. None were double positive. Anti-N and anti-S antibodies were detected in 5·2% [4·2-6·5%] and 2·1% [1·1-3·9%] of the general community, 2·0% [1·1-3·3%] and 1·4% [0·5-3·7%] of healthcare workers and 20·3% [12·6-31·0%] and 6·8% [2·8-15·3%] of bat/wildlife contacts. 0·1% [0·02-0·3%] were double positive for anti-N and anti-S antibodies (rapid test negative). Interpretation We find no evidence for significant SARS-CoV-2 circulation in Lao PDR before September 2020. This likely results from early decisive measures taken by the government, social behavior, and low population density. High anti-N /low anti-S seroprevalence in bat/wildlife contacts may indicate exposure to cross-reactive animal coronaviruses with threat of emerging novel viruses. Funding Agence Française de Développement. Additional; Institut Pasteur du Laos, Institute Pasteur, Paris and Luxembourg Ministry of Foreign and European Affairs (“PaReCIDS II”).

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“…Data for the present study were obtained from the first survey in July, 2020 (after the first wave of epidemic in Japan), of the NCGM Clinical Epidemiology Study on the SARS-CoV-2 antibody, an ongoing epidemiological study involving staff members at the NCGM. 15 The objective of the study was to investigate the prevalence and determinants of SARS-CoV-2 infection. On recruitment, participants were asked to complete an electronic questionnaire on sociodemographic factors, COVID-19-related work factors, lifestyle factors, and depressive symptoms.…”

Section: Methodsmentioning

confidence: 99%

Association Between Adherence to Healthy Lifestyles and Depressive Symptoms Among Japanese Hospital Workers During the COVID-19 Pandemic

Fukunaga

Inoue

Yamamoto

et al. 2021

Asia Pac J Public Health

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The objective of this study was to investigate the association between adherence to healthy lifestyles (as measured by the healthy lifestyle index [HLI]) and depressive symptoms among staff members at a large national medical institution in Tokyo, Japan, during the coronavirus disease 2019 (COVID-19) pandemic. The study sample consisted of 1228 staff members aged between 21 and 73 years who participated in a cross-sectional survey conducted in July 2020. We constructed the HLI by assigning 1 point to each healthy lifestyle factor: normal body mass index, sufficient physical activity, non-smoking status, non-to-moderate alcohol consumption, and sufficient sleep duration. The multivariate adjusted odds ratios (95% confidence interval) for depressive symptoms were 1.00 (reference), 0.71 (0.46-1.11), 0.66 (0.43-1.01), and 0.56 (0.33-0.94) for participants with HLI scores of 0 to 2, 3, 4, and 5, respectively ( P for trend = 0.032). The present study suggests the role of healthy lifestyles in mental health among hospital staff working during the pandemic.

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Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan

Cited by 24 publications

References 8 publications

COVID-19 breakthrough infections and pre-infection neutralizing antibody

COVID-19 breakthrough infections and pre-infection neutralizing antibody

Low seroprevalence of COVID-19 in Lao PDR, late 2020

Association Between Adherence to Healthy Lifestyles and Depressive Symptoms Among Japanese Hospital Workers During the COVID-19 Pandemic

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