Seroprevalence of Anti-SARS-CoV-2 Antibodies among Outpatients in Southwestern Seoul, Korea

Noh, Ji Yun; Seo, Yu Bin; Yoon, Jin Gu; Seong, Hye; Hyun, Hakjun; Jacob, Louis; Lee, Nuri; Jung, Sung Ui; Park, Min Jeong; Song, Wonkeun; Yoon, Joon Shik; Lim, Chae Seung; Ryou, Jungsang; Lee, Joo Yeon; Kim, Sung Soon; Cheong, Hee Jin; Kim, Woo Joo; Yoon, Soo Young; Song, Joon Young

doi:10.3346/jkms.2020.35.e311

Cited by 34 publications

(48 citation statements)

References 13 publications

(14 reference statements)

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“…For other studies, healthy volunteer bias 19 may underestimate seroprevalence, attracting people with symptoms 26 may overestimate seroprevalence, and studies of employees, 14 , 21 , 25 , 32 , 66 grocery store clients 23 or patient cohorts 11 , 14 , 27 – 30 , 36 , 38 , 40 , 50 , 51 , 56 , 59 , 62 , 64 , 67 risk sampling bias in an unpredictable direction.…”

Section: Resultsmentioning

confidence: 99%

Infection fatality rate of COVID-19 inferred from seroprevalence data

Ioannidis

2020

Bull. World Health Organ.

357

320

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Objective To estimate the infection fatality rate of coronavirus disease 2019 (COVID-19) from seroprevalence data. Methods I searched PubMed and preprint servers for COVID-19 seroprevalence studies with a sample size ≥ 500 as of 9 September 2020. I also retrieved additional results of national studies from preliminary press releases and reports. I assessed the studies for design features and seroprevalence estimates. I estimated the infection fatality rate for each study by dividing the cumulative number of COVID-19 deaths by the number of people estimated to be infected in each region. I corrected for the number of immunoglobin (Ig) types tested (IgG, IgM, IgA). Findings I included 61 studies (74 estimates) and eight preliminary national estimates. Seroprevalence estimates ranged from 0.02% to 53.40%. Infection fatality rates ranged from 0.00% to 1.63%, corrected values from 0.00% to 1.54%. Across 51 locations, the median COVID-19 infection fatality rate was 0.27% (corrected 0.23%): the rate was 0.09% in locations with COVID-19 population mortality rates less than the global average (< 118 deaths/million), 0.20% in locations with 118–500 COVID-19 deaths/million people and 0.57% in locations with > 500 COVID-19 deaths/million people. In people younger than 70 years, infection fatality rates ranged from 0.00% to 0.31% with crude and corrected medians of 0.05%. Conclusion The infection fatality rate of COVID-19 can vary substantially across different locations and this may reflect differences in population age structure and case-mix of infected and deceased patients and other factors. The inferred infection fatality rates tended to be much lower than estimates made earlier in the pandemic.

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Section: Resultsmentioning

confidence: 99%

Infection fatality rate of COVID-19 inferred from seroprevalence data

Ioannidis

2020

Bull. World Health Organ.

357

320

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“…A thorough assessment of the duration of protective immunity will be critical for determining the necessary measures to prevent and respond to future waves of SARS-CoV-2 infection. Such information must be gathered widely from various locations worldwide to reflecting the unique local conditions ( Noh et al, 2020 , Stringhini et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The seroprevalence of SARS-CoV-2 IgG antibodies among asymptomatic blood donors in Saudi Arabia

Mahallawi

Al‐Zalabani

2021

Saudi Journal of Biological Sciences

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“…We assumed that unvaccinated people are initially susceptible and even vaccinated individuals might become infected at a reduced rate. In South Korea, the proportion of seropositive individuals is minimal at present (estimated at 0.07%) [ 30 ], and the rate of under-reporting is relatively low [ 31 ]. Specifically, the true number of cases exceeded the reported figure by a factor of 2.6, which is relatively low compared to those in other countries [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea

Shim

2021

JCM

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Initial supply of the coronavirus disease (COVID-19) vaccine may be limited, necessitating its effective use. Herein, an age-structured model of COVID-19 spread in South Korea is parameterized to understand the epidemiological characteristics of COVID-19. The model determines optimal vaccine allocation for minimizing infections, deaths, and years of life lost while accounting for population factors, such as country-specific age distribution and contact structure, and various levels of vaccine efficacy. A transmission-blocking vaccine should be prioritized in adults aged 20–49 years and those older than 50 years to minimize the cumulative incidence and mortality, respectively. A strategy to minimize years of life lost involves the vaccination of adults aged 40–69 years, reflecting the relatively high case-fatality rates and years of life lost in this age group. An incidence-minimizing vaccination strategy is highly sensitive to vaccine efficacy, and vaccines with lower efficacy should be administered to teenagers and adults aged 50–59 years. Consideration of age-specific contact rates and vaccine efficacy is critical to optimize vaccine allocation. New recommendations for COVID-19 vaccines under consideration by the Korean Centers for Disease Control and Prevention are mainly based on a mortality-minimizing allocation strategy.

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Seroprevalence of Anti-SARS-CoV-2 Antibodies among Outpatients in Southwestern Seoul, Korea

Cited by 34 publications

References 13 publications

Infection fatality rate of COVID-19 inferred from seroprevalence data

Infection fatality rate of COVID-19 inferred from seroprevalence data

The seroprevalence of SARS-CoV-2 IgG antibodies among asymptomatic blood donors in Saudi Arabia

Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea

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