Seroprevalence and Trends in Transfusion Transmitted Infections Among Blood Donors in a University Hospital Blood Bank: A 5 Year Study

Abstract

Blood is life. Transfusion of blood and blood components, as a specialized modality of patient management saves millions of lives worldwide each year and reduce morbidity. It is well known that blood transfusion is associated with a large number of complications, some are only trivial and others are potentially life threatening, demanding for meticulous pretransfusion testing and screening particularly for transfusion transmissible infections (TTI). These TTI are a threat to blood safety. The priority objective of BTS is thus to ensure safety, adequacy, accessibility and efficiency of blood supply at all levels. The objective of the present study was to assess the prevalence and trend of transfusion transmitted infections (TTI) among voluntary and replacement donors in the Department of Blood bank and transfusion Medicine of JSS College Hospital, a teaching hospital of Mysore during the period from 2004 to 2008. A retrospective review of donors record covering the period between 2004 and 2008 at the blood bank, JSS Hospital, Mysore was carried out. All samples were screened for HIV, HBsAg, HCV, syphilis and malaria. Of the 39,060, 25,303 (64.78%) were voluntary donors and the remaining 13,757 (35.22%) were replacement donors. The overall prevalence of HIV, HbsAg, HCV and syphilis were 0.44, 1.27, 0.23 and 0.28%, respectively. No blood donor tested showed positivity for malarial parasite. Majority were voluntary donors with male preponderance. In all the markers tested there was increased prevalence of TTI among the replacement donors as compared to voluntary donors. With the implementation of strict donor criteria and use of sensitive screening tests, it may be possible to reduce the incidence of TTI in the Indian scenario.

Seroprevalence of Hiv and HBsAg among Blood Donors of a Tertiary Care Hospital:A Cross Sectional Study from Khammam, Andhra Pradesh

“…Dominancy of male blood donors were also found in a study conducted in North India, which was in accordance with our study [20]. There are some other reports supported this outcome [19][20][21][22][23]. There could be another possibility that, females due to their poor nutritional status may be anemic, so they were unwilling to donate blood.…”

A Retrospective Study of Screening of Common Transfusion Transmitted Infections in the Blood Bank of a Tertiary Care Centre

“…But Pallavi et al observed in their study a much higher prevalence of 0.28% with respect to syphilis [11]. In the recent years syphilis has also acquired a new potential for morbidity and mortality through association with increased risk of HIV infection, thus making safe blood more difficult to get.…”

Spectrum of Transfusion Transmitted Infections Among Apparently Healthy Blood Donors in Blood Bank RIMS Ranchi From 2008 to 2014

“…Seropositivity of VDRL infection has been constant (0.01%) in the last 12 years from 2001 -2012. The data which provides a picture of TTI burden in India has come from various seroprevalence studies (Table 4 and Table 5 [19]. The Indian National AIDS Control Organization (NACO) suggested an overall prevalence of 0.91% (2005) in India with 0.25% in Delhi [21].…”