Seroprevalence and seroconversion rates to SARS-CoV-2 in interns, residents, and medical doctors in a University Hospital in Bogotá, Colombia

Ariza, Beatriz Ruiz; Torres, X.; Salgado, Diana; Cepeda, M. Soledad; Restrepo, Carlos Gómez; Ramírez, Julio César Castellanos; Süárez-Obando, Fernando; Cuéllar, Adriana; Cardozo, Claudia; Ángel, Juana; Franco, Manuel

doi:10.22354/in.v25i3.938

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…One reason could be that HCW adhere more to biosafety measures if they feel responsible for their family. On the contrary, comorbidities previously associated with severity (47)(48)(49) were not associated with the infection in our study (50).…”

Section: Discussioncontrasting

confidence: 89%

A Case-Control Study of Factors Associated with SARS-CoV-2 Infection Among Healthcare Workers in Colombia.

Rodríguez‐López

Parra

Vergara

et al. 2021

Preprint

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Background: Healthcare Workers (HCW) are repeatedly exposed to SARS-CoV-2 infection. The aim of this study was to identify factors associated with SARS-CoV-2 infection among HCW in one of the largest cities in Colombia. Methods: We conducted a case-control study, where cases had a positive reverse transcription-polymerase chain reaction and controls had a negative result. Participants were randomly selected and interviewed by phone. Analyses were performed using logistic regression models. Results: A total of 110 cases and 113 controls were included. Men (AdjOR 4.1 95%CI 1.7-10), Nurses (AdjOR 11.2 95%CI 1.1-119.6), not using a high-performance filtering mask (AdjOR 2.2 95%CI 1-5.1) and inadequate use of personal protective equipment (AdjOR 4.8 95%CI 1.1-19.6) were identified as risk factors. Conversely, graduate (AdjOR 0.1 95%CI 0.01-0.5) and postgraduate (AdjOR 0.05 95%CI 0.004-0.5) education, feeling scared or nervous (AdjOR 0.5 95%CI0.2-0.9), not wearing any of gloves, hat and googles/face shields (AdjOR 0.1 95%CI0.02-0.4), and the use of high-performance filtering or a combination of fabric plus surgical mask (AdjOR 0.2 95%CI 0.1-0.8) outside the workplace were protective factors. Conclusion: This study highlights the protection provided by high-performance filtering mask or double masking among HCW. Individual factors and the difficulties of wearing other protective equipment needs to be considered in designing, implementing and monitoring COVID-19 biosafety protocols for HCW.

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Section: Discussioncontrasting

confidence: 89%

A Case-Control Study of Factors Associated with SARS-CoV-2 Infection Among Healthcare Workers in Colombia.

Rodríguez‐López

Parra

Vergara

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…However, other studies conducted in North American grounds such as that of Stubblefield et al or that of Hunter et al display a noticeable heterogeneity, with positivity rates of 7.6% and 1.6% in July and August, respectively (21,22). A South-American study estimated seroprevalence among HCW at a University Hospital in Colombia in December at nearly 6% (23). These compiled data connote that HCW, who have an augmented exposure to the virus and hence an increased probability of becoming infected, do have an increased seroprevalence as compared to general data from the aforementioned dashboard.…”

Section: Seroprevalencementioning

confidence: 94%

Antibody Responses in COVID-19: A Review

et al. 2021

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide as a severe pandemic. Although its seroprevalence is highly variable among territories, it has been reported at around 10%, but higher in health workers. Evidence regarding cross-neutralizing response between SARS-CoV and SARS-CoV-2 is still controversial. However, other previous coronaviruses may interfere with SARS-CoV-2 infection, since they are phylogenetically related and share the same target receptor. Further, the seroconversion of IgM and IgG occurs at around 12 days post onset of symptoms and most patients have neutralizing titers on days 14-20, with great titer variability. Neutralizing antibodies correlate positively with age, male sex, and severity of the disease. Moreover, the use of convalescent plasma has shown controversial results in terms of safety and efficacy, and due to the variable immune response among individuals, measuring antibody titers before transfusion is mostly required. Similarly, cellular immunity seems to be crucial in the resolution of the infection, as SARS-CoV-2-specific CD4+ and CD8+ T cells circulate to some extent in recovered patients. Of note, the duration of the antibody response has not been well established yet.

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“…Currently, and especially in Latin America, not enough studies have been conducted to assess the seroprevalence for COVID-19 in health care workers who are involved in the primary care of patients with COVID-19 infection. 15 The present study is one of the first reports in Colombia to study the seroprevalence in health care workers with a high burden of patients with SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 85%

Prevalence of Anti-SARS-CoV-2 Antibodies and Associated Factors Among Health Care Workers in Santiago De Cali, Colombia

Osorio-Toro¹,

Bonilla-Bonilla²,

Arana³

et al. 2023

IJGM

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Purpose This study aims to determine the seroprevalence of coronavirus disease (COVID-19) among health care workers and describe the associated sociodemographic and labor features. Patients and Methods An observational study with an analytical component was conducted at a clinic in Cali, Colombia. The sample size was 708 health workers and they were selected by stratified random sampling. A Bayesian analysis was developed to determine the raw and adjusted prevalence. A Poisson regression model was used to estimate the prevalence ratios. Results Overall seroprevalence of COVID-19 among healthcare workers was 29%. Miscellaneous services workers, healthcare, and administrative workers, was 38%, 33%, and 32%, respectively. Factors related to seropositivity were having a contact with a COVID-19 patient for >120 minutes and being diagnosed with COVID-19 by laboratory tests. Conclusion The present study shows a adjusted seroprevalence of 29% in health workers, indicating a high level of disease transmission and an increased risk of infection in this population group.

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Seroprevalence and seroconversion rates to SARS-CoV-2 in interns, residents, and medical doctors in a University Hospital in Bogotá, Colombia

Cited by 10 publications

References 24 publications

A Case-Control Study of Factors Associated with SARS-CoV-2 Infection Among Healthcare Workers in Colombia.

A Case-Control Study of Factors Associated with SARS-CoV-2 Infection Among Healthcare Workers in Colombia.

Antibody Responses in COVID-19: A Review

Prevalence of Anti-SARS-CoV-2 Antibodies and Associated Factors Among Health Care Workers in Santiago De Cali, Colombia

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