Seroprevalence and risk factors of Coxiella burnetii infection among high-risk population in center of Iran, a neglected health problem

Nokhodian, Zary; Ataei, Behrooz; Moradi, Abdolreza; Yaran, Majid; Hoseini, Shervin Gaffari; Feizi, Awat; Sherkat, Roya

doi:10.1016/j.actatropica.2017.02.002

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Similar observations with regard to the sensitivity of trans-PCR and com1-PCR have been reported in recent studies, wherein these tests could detect the pathogens in 63% and 30% [22], 17.14% and 10% [23] of clinical samples, respectively. In a systematic review on epidemiology of C. burnetii in Iran, a higher prevalence was observed in PCR assays based on the IS1111 gene (11%) as compared to the com1 gene (4%) [24].…”

Section: Discussionmentioning

confidence: 99%

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Apparent prevalence and risk factors of coxiellosis (Q fever) among dairy herds in India

et al. 2020

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Coxiella burnetii is a highly infectious zoonotic pathogen infecting wide range of mammals, including humans. In the present study, a total of 711 blood samples from bovines [cattle (n = 543) and buffaloes (n = 168)] from eight farms at different geographical locations in India were screened for C. burnetii targeting the IS1111 and the com1 genes. The anti-C. burnetii antibodies in serum samples were detected using indirect-ELISA kits. Also, a total of 21 parameters pertaining to animal health and farm management were identified to assess their role as possible risk factors for coxiellosis among the targeted farms. The apparent prevalence (positive for PCR and/or ELISA) for coxiellosis was reported to be 24.5% in cattle and 8.9% in buffaloes. In cattle, the detection rate of C. burnetii employing the IS1111 gene (8.5%) was found to be significantly higher (p<0.05) as compared to the com1 (6.5%) gene. The seropositivity by ELISA was higher among cattle (17.7%) than in buffaloes (8.3%). Further, on univariable analysis of risk factors, species (cattle) (

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Section: Discussionmentioning

confidence: 99%

“…In a systematic review on epidemiology of C . burnetii in Iran, a higher prevalence was observed in PCR assays based on the IS1111 gene (11%) as compared to the com1 gene (4%) [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Apparent prevalence and risk factors of coxiellosis (Q fever) among dairy herds in India

et al. 2020

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“…An Iranian serologic study of C. burnetii infection tested by IFA reported a seroprevalence (phase II IgG titer ≥1:64) of 46.5% among slaughterhouse workers and butchers [ 18 ], while another similar study which tested by enzyme-linked immunosorbent assay (ELISA) in the southeast of Iran identified a seroprevalence of 68.0% among slaughterhouse workers [ 19 ]. An Italian study performed among slaughterhouse workers produced a comparatively high seroprevalence of 73.7%, tested by ELISA [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Seroreactivity and Risk Factors Associated with Coxiella burnetii Infection among Cattle Slaughterhouse Workers in South Korea

Park

Hwang

Acharya

et al. 2018

IJERPH

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Q fever, caused by Coxiella burnetii, is a zoonotic disease that is an occupational hazard to people who work in close contact with animals or their carcasses. A nationwide serologic study among cattle slaughterhouse workers who were presumed to be at risk of having C. burnetii infection in South Korea was performed to investigate the seroreactivity of C. burnetii infection and identify related risk factors. Out of 1017 cattle slaughterhouse workers in South Korea, 923 (90.8%) participated in this cross-sectional study. Samples were tested for immunoglobulin G (IgG) and M (IgM) antibodies against phase II C. burnetii via indirect immunofluorescence assay. The overall seroreactivity, defined as IgG or IgM antibody titer cutoffs ≥1:16, was 9.1% (84/923). Additionally, a significant association was found between the seroreactivity of C. burnetii infection and performing carcass evisceration work (odds ratio, 2.36; 95% confidence interval, 1.39–4.03) in multivariate analysis. To diminish C. burnetii infection, cattle slaughterhouse workers need to take precautions during the evisceration process.

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“…In the recent years, the different epidemiological profile of C. burnetii infections was reported in Iran. In the seroprevalence studies Q fever infection rates varied from 7.8% to 68% in the different sources (animals and high-risk population) (Khalili and Sakhaee, 2009;Aflatoonian et al, 2014;Azizzadeh et al, 2014;Esmaeili et al, 2014;Esmaeili et al, 2017Nokhodian et al, 2017). In the molecular studies the prevalence rate of C. burnetii DNA was reported from 0% to 48.15% in various samples (animals, human and ticks) by amplification of different genes included IS1111, 16S rRNA and Com1 (Rahimi et al, 2010;Dehkordi 2011;Jamshidi et al, 2014;Khademi et al, 2014;Nokhodian et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Molecular Analysis of Coxiella Burnetii by Isocitrate Dehydrogenase Gene Sequence-Based Typing and PCR-RFLP in Isfahan, Iran.

Nokhodian¹,

Khalili²,

Ataei³

et al. 2019

jwpr

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In the recent years, considerable advances have been made in the detection and genotyping of Coxiella burnetii, the causative agent of Q fever. The selection of appropriate genotyping method has enabled description of the clonal diversity of C. burnetii around the word. Since, in the place of study, C. burnetii genotyping has not been done, the icd gene Restriction fragment length polymorphism (RFLP) and sequence-based typing for differentiation between the genomic detected C. burnetii from the various sources and compared the two methods is used. In a observational study, a total of 15 genomic positive cases of C. burnetii infection from different sources in Isfahan province (Central Iran) were enrolled and underwent two genotyping methods: the icd gene PCR-RFLP and icd gene sequence-based typing. The degree of similarity between the icd gene sequences was high (98.3-100%). In compare with C. burnetii Nine Mile icd gene sequence, the nucleotide sequences were different at 11 positions, which resulted in 7 differences in the amino acid sequences. After digesting the 370 bp amplified icd gene fragments all the samples indicated only one band of 370bp, while amplified C. burnetii Nine Mile strain icd gene were digested into two bands with sizes of 221bp and 149bp. The results of two genotyping methods matched together. Used methods in present study were cheaper and easier than new methods and they can used for detection of acute and chronic phases of infection.

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Seroprevalence and risk factors of Coxiella burnetii infection among high-risk population in center of Iran, a neglected health problem

Cited by 6 publications

References 16 publications

Apparent prevalence and risk factors of coxiellosis (Q fever) among dairy herds in India

Apparent prevalence and risk factors of coxiellosis (Q fever) among dairy herds in India

Seroreactivity and Risk Factors Associated with Coxiella burnetii Infection among Cattle Slaughterhouse Workers in South Korea

Molecular Analysis of Coxiella Burnetii by Isocitrate Dehydrogenase Gene Sequence-Based Typing and PCR-RFLP in Isfahan, Iran.

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