Seroprevalence and risk factors of Crimean–Congo hemorrhagic fever in selected seven provinces in Turkey

Yağcı-Çağlayık, Dilek; Korukluoğlu, Gülay; Uyar, Yavuz

doi:10.1002/jmv.23699

Cited by 35 publications

(49 citation statements)

References 33 publications

(58 reference statements)

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“…Seroprevalence was reported as 10-19.6% in endemic regions of Turkey. Seropositivity in individuals with a history of farming, animal husbandry, contact with animals and contact with ticks was 80%, 70%, 76% and 70% respectively 6,8,30,[31][32][33][34] . In Iran, contact with infected humans and animals was higher in the CCHF group than the non-CCHF group, but, a history of tick bite was not a risk factor 20 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cases with a preliminary diagnosis of Crimean- Congo hemorrhagic fever and comparison of characteristics in patients admitted to a secondary care hospital in Kastamonu, Turkey.

Hekimoğlu

Demirci

2015

Afr H. Sci.

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Abstract:Background: Crimean-Congo hemorrhagic fever (CCHF) is an endemic disease in Turkey. The clinical presentation and laboratory findings are not specific especially in cases without hemorrhagic findings. Objective: We aimed to evaluate CCHF cases and compare them with non-CCHF cases in terms of their characteristics during admission. Methods: Cases with a preliminary diagnosis of CCHF at a secondary care hospital in Kastamonu in 2013 were evaluated, retrospectively. Cases testing RNA/IgM positive were considered as CCHF. Cases testing both RNA and IgM negative were considered as non-CCHF. The two groups were then compared in terms of their clinical, laboratory and epidemiological characteristics during admission. Results: A total of 41 cases were tested and CCHF was found in 46.3% of cases. Fatality was 5.3% in CCHF cases. The frequency of tick bites and CK elevation in CCHF cases was significantly higher than non-CCHF cases (p<0.05). There were no significant differences between the two groups regarding other characteristics (p>0.05). Conclusions:In cases with a preliminary diagnosis of CCHF, especially in cases without a history of tick bite and with normal CK levels during admission, performing tests for the differential diagnosis may be advisable without waiting for the results of tests for CCHF.

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Section: Discussionmentioning

confidence: 99%

Evaluation of cases with a preliminary diagnosis of Crimean- Congo hemorrhagic fever and comparison of characteristics in patients admitted to a secondary care hospital in Kastamonu, Turkey.

Hekimoğlu

Demirci

2015

Afr H. Sci.

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“…The studies conducted in Turkey also showed high variability. Most studies showed a seroprevalence that ranged from low values (0.5% [44], 1.2% [38], 1.8% [49], 2.3% [50], and 3.7% [42]) to moderate values (9.6% [48], 10% [4], 10.9% [41], 12.8% [45], 13.6% [47], 14.4% [34], and 15.8% [37]. One study showed a much higher prevalence (19.6% [39]), but this study was performed in an endemic area in southwestern Turkey.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Seroprevalence of Crimean-Congo hemorrhagic fever in humans in the World Health Organization European region: A systematic review

et al. 2020

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Background Crimean-Congo hemorrhagic fever (CCHF) is an emerging infectious disease caused by a Nairovirus. CCHF is a tick-borne disease that is predominantly associated with Hyalomma ticks and have a widespread distribution in Africa, Asia and Europe. CCHF usually presents as a subclinical disease, but in some cases, it may present as a hemorrhagic fever with a high mortality rate. This systematic review of the literature was performed to identify the available evidence on the prevalence of CCHF in the European Region of the World Health Organization, based on seroprevalence (IgG antibodies). Methodology A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. PubMed, Embase, and the Web of Science were used for the search (up to January 31, 2019), combining the following MeSH terms: ["Crimean-Congo haemorrhagic fever" OR "Crimean-Congo hemorrhagic fever virus" OR "Congo-Crimea" OR "Crimea-Congo"] AND ["Europe"] AND ["epidemiology" OR "seroprevalence"]. The abstracts were screened. Subsequently, full-text articles were selected and reviewed based on the PICOS (Population-Intervention-Comparison-Outcomes-Study type) criteria by two independent reviewers for inclusion in the final analysis.

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“…Ertuğrul ve arkadaşları (5) Aydın ilindeki endemik bölgelerde yaptıkları seroprevalans çalışmasında, büyükbaş hayvan besleme öy-küsüyle antikor varlığı arasında istatistiksel olarak anlamlı bir ilişki saptamışlardır. Yağcı-Çağlayık ve arkadaşları (8), çiftçilik ve hayvan beslemeyle uğraşan grupların yüksek seropozitiflik gösterdiklerini bildirmişlerdir. Buna karşılık Bodur ve arkadaşları (2), çalışmamızla benzer şekilde, hayvancılık ve avlanma öyküsünün seropozitif bireylerde daha fazla olmadığını saptamışlar, farklı olarak kene yapışmasıyla seropozitiflik arasında anlamlı bir ilişki olduğunu göster-mişlerdir.…”

Section: Bulgularunclassified

A New Endemic Province of Crimean-Congo Haemorrhagic Fever in Turkey: Aydin

Ozturk¹,

Kırdar²,

Ertuğrul³

et al. 2017

Klimik Dergisi

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Objective: Crimean-Congo haemorrhagic fever (CCHF) has been reported particularly in the north-eastern part of Anatolia in Turkey. However, in recent years, many cases have been reported from western cities. Although Aydin is considered as a non-endemic area, 50 cases have been reported between 2006 and 2014. In a previous study, IgG seropositivity was found to be 19.6% in the endemic regions of Aydin. The aim of this study is to determine the seropositivity rates and contributing factors in non-endemic regions of Aydin as well as revealing the position of Aydin on the CCHF map of Turkey. Methods: Two hundred and ninety-three volunteers were enrolled in this study. Volunteers were asked seventeen questions related to demographic and factual features by face-to-face interviews. The VectoCrimea-CHF-IgG (Vector-Best, Novosibirsk, Russia) ELISA diagnostic kit was used to detect the virus-specific antibodies in serum samples of the volunteers. Results: IgG seropositivity in the study group was found to be 19.7% (n=58). Twenty-seven (27%) of 100 female participants and 31 (16.1%) of 193 male participants were seropositive for CCHF virus (p<0.05). Seropositivity was significantly higher in female sex (p=0.02). The most effective variable on IgG positivity in χ 2 automatic interaction detection analysis was found to be the region. The highest seropositivity was found in Aydin city centre with 29.5% among all study areas (p=0.006). Conclusions: In our study, we found that seropositivity of nonendemic regions (19.7%) was similar to the endemic regions (19.6%) in Aydin. In high risk areas of our country, IgG seroprevalence is reported as 12.8%. So, we think that Aydin should be considered as an endemic city.

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Seroprevalence and risk factors of Crimean–Congo hemorrhagic fever in selected seven provinces in Turkey

Cited by 35 publications

References 33 publications

Evaluation of cases with a preliminary diagnosis of Crimean- Congo hemorrhagic fever and comparison of characteristics in patients admitted to a secondary care hospital in Kastamonu, Turkey.

Evaluation of cases with a preliminary diagnosis of Crimean- Congo hemorrhagic fever and comparison of characteristics in patients admitted to a secondary care hospital in Kastamonu, Turkey.

Seroprevalence of Crimean-Congo hemorrhagic fever in humans in the World Health Organization European region: A systematic review

A New Endemic Province of Crimean-Congo Haemorrhagic Fever in Turkey: Aydin

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