Seroprevalence and risk factors of Hepatitis E virus infection among pregnant women attending antenatal care in health facilities of Tigray, Northern Ethiopia

Niguse, Selam; Hailekiros, Haftamu; Buruh, Gerezgiher; Dejene, Tadese; Berhe, Nega; Asmelash, Tsehaye

doi:10.1002/jmv.25190

Cited by 11 publications

(11 citation statements)

References 20 publications

(29 reference statements)

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“…Walter Reed Army Institute of Research in-house assay). The most common assays used to assess seroprevalence were in-house assays (21%) (14,34,44,47,51,53,56,60,61,70,72,79,84,91,97,100), Wantai (18%; Wantai BioPharm, Beijing, China) (20–23,31,40,46,48,54,59,63,65,76,77), and Abbott (14%; (Abbott Diagnostika, Germany) (15,18,28,32,43,80,82,83,87,93,94) with the Wantai assay becoming the most commonly used assay in studies conducted in the last 5 years of the review (2013-2017).…”

Section: Resultsmentioning

confidence: 99%

Setting a course for preventing hepatitis E in low and lower-middle-income countries: A systematic review of burden and risk factors

Koyuncu

Mapemba

Ciglenečki³

et al. 2020

Preprint

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BackgroundHepatitis E virus is responsible for outbreaks of acute jaundice in Africa and Asia, many of which occur among displaced people or in crisis settings. While an efficacious vaccine for HEV has been developed, we lack key epidemiologic data needed to understand how best to use the vaccine for hepatitis E control in endemic countries.MethodsWe conducted a systematic review of articles published on hepatitis E in low and lower-middle-income countries (LMIC) in Africa and Asia. We searched PubMed, Scopus, and Embase databases to identify articles with data on anti-HEV IgG seroprevalence, outbreaks of HEV, or risk factors for HEV infection, disease, or death, and all relevant data were extracted. Using these data we describe the evidence around temporal and geographical distribution of HEV transmission and burden. We estimated pooled age-specific seroprevalence and assessed the consistency in risk factor estimates.ResultsWe extracted data from 148 studies. Studies assessing anti-HEV IgG antibodies used 18 different commercial assays. Most cases of hepatitis E during outbreaks were not confirmed. Risk factor data suggested an increased likelihood of current or recent HEV infection and disease associated with fecal-oral transmission of HEV, as well as exposures to blood and animals.ConclusionHeterogeneity in diagnostic assays used and exposure and outcome assessment methods hinder public health efforts to quantify burden of disease and evaluate interventions over time and space. Prevention tools such as vaccines are available, but require a unified global strategy for hepatitis E control to justify widespread use.

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Section: Resultsmentioning

confidence: 99%

Setting a course for preventing hepatitis E in low and lower-middle-income countries: A systematic review of burden and risk factors

Koyuncu

Mapemba

Ciglenečki³

et al. 2020

Preprint

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“…Pro, three studies Euroimmun, two studies International immune diagnostics, two studies TMB and other elven studies used different ELISA assay methods (Table 1). Mean age of the studies were specified in 18 studies ranged from 13 years Adje et al [38] to 50 years Nigussie et al [34].…”

Section: Resultsmentioning

confidence: 99%

“…ProFlorence et al [27]2016CSBurkina Faso18–45179Mixed10.6Creative diagnosticNoufensi et al [28]. 2016CSCameroon16–41200Mixed9PristigeGad et al [29]2011CSEgypt15–41116Mixed58.6GenelabsStoszek et al [30]20051997/2003CSEgypt16–48-2428Rural84.3In house EIAEl-shety et al [31]2014CSEgypt17–40100Rural45OthersTekeste et al [32]20172016CSEritrea15–49153Mixed26.8EuroimmunAbebe et al [33]20172015CSEthiopia16–40386Mixed31.6WantiNigussie et al [34]20182016CSEthiopia18–50846Mixed42.4WantiTsega et al [35]19931988/91CohortEthiopia15–4532Mixed59OthersCaron et al [36]20082005CSGabon14–44840Mixed14.1TMBCaron et al [37]20122008CSGabon14–432436.6TMBAdjei et al [38]20162008CSGhana13–42157Mixed28.7Interna immuno diag.Obiri-Yeboah et al […”

Section: Resultsmentioning

confidence: 99%

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Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis

et al. 2019

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Background There have been a number of studies about seroprevalence of HEV among pregnant women in Africa. However, the finding of seroprevalence of HEV infection among pregnant women is variable and inconsistent. Therefore; this systematic review intended to provide the pooled seroprevalence of HEV among pregnant women in Africa. Methods We searched, Pub Med, Science direct, African online journals and Google scholar electronic data bases and all available references until August 30, 2018. We included cross sectional studies and cohort studies. The search was further limited studies done in African pregnant women. Statistical analysis done by using Stata (version 11) software. The overall pooled prevalence of HEV presented by using the forest plot with 95% CI. The methodological qualities of included studies were assessed using Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instruments. Result The pooled seroprevalence of HEV among pregnant women in Africa was 29.13% (95% CI 14.63–43.63). The highest seroprevalence was 84.3% in Egypt and the lowest 6.6% reported in Gabon. There was highest heterogeneity level where I 2 = 99.7%; P < 0.0001.The observed heterogeneity attributed to geographic location/ region, country, assay method used in each study and year of study published. Moreover, HEV seroprevalence varies between countries and within countries. The HEV infection among African pregnant women seems to have a decreasing trend over time. Conclusion The seroprevalence of HEV among pregnant women in Africa is high. The seroprevalence of HEV among pregnant women differ with geographic location and assay method. Therefore, it is recommended to conduct further research on commercial ELISA kit sensitivity and specificity, molecular tests, incidence, morbidity and mortality and vertical transmission of HEV from mother to infant in Africa. Trial registration CRD42018084963 . Electronic supplementary material The online version of this article (10.1186/s12879-019-4125-x) contains supplementary material, which is available to authorized users.

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“…83 An outbreak of HEV in Ethiopia caused 14 of 39 intrauterine deaths. 85 Huangfen et al used a mouse model to evaluate the adverse outcomes of HEV during pregnancy in HEV-infected pregnant mice. 86 They found HEV-RNA and antigens in the uterus and placental cells implying that the virus replicated in those tissues.…”

Section: Hepatitis E Virus (Hev)mentioning

confidence: 99%

Potential role of viral infections in miscarriage and insights into the underlying molecular mechanisms

Heydarifard

Zadheidar

Yavarian

et al. 2022

Congenital Anomalies

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Intrauterine viruses can infect the decidua and placenta and cause adverse effects on the fetus during gestation. This review discusses the contribution of various viral infections to miscarriage and the molecular mechanisms by which viruses can cause devastating effects on healthy fetuses and induce miscarriage. Severe acute respiratory syndrome coronavirus 2 as newly emerged coronavirus was considered here, due to the concerns about its role during pregnancy and inducing miscarriage, as well.In this narrative review, an extensive literature search was conducted to find all studies investigating viral infections in miscarriage and their molecular mechanisms published over the past 20 years. The results of various studies investigating the roles of 20 viral infections in miscarriage are presented. Then, the mechanisms of pregnancy

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Seroprevalence and risk factors of Hepatitis E virus infection among pregnant women attending antenatal care in health facilities of Tigray, Northern Ethiopia

Cited by 11 publications

References 20 publications

Setting a course for preventing hepatitis E in low and lower-middle-income countries: A systematic review of burden and risk factors

Setting a course for preventing hepatitis E in low and lower-middle-income countries: A systematic review of burden and risk factors

Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis

Potential role of viral infections in miscarriage and insights into the underlying molecular mechanisms

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