Seroprevalence and Risk Factors for Human Papillomavirus in Taiwan

Wang, I. J.; Viscidi, Raphael P.; Hwang, Kung‐Chang; Lin, Tzu-Yu; Chen, C. J.; Huang, Li‐Min; Chen, H. H.

doi:10.1093/tropej/fmm062

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…This supports the recommendations that HPV vaccination should begin at younger ages. Interestingly, any HPV and type-specific seroprevalence increased with age even at older ages, consistent with data from cross-sectional studies in Taiwan [24], China [25], Mongolia [21] and England [26]. However, the observed seroprevalence age-trend in Chile differs from reports in the US [27,28], Costa Rica [11], The Netherlands [29] and Australia [30], where seroprevalence peaked one or two decades after sexual debut and steadily declined after ages 50 or 60 years.…”

Section: Discussionsupporting

confidence: 88%

Serological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chile

et al. 2014

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BackgroundHuman papillomavirus (HPV) serology is a main factor for designing vaccination programs and surveillance strategies; nevertheless, there are few reports of HPV seroprevalence in the general population, especially in Latin America. This study aimed to describe high-risk HPV serological prevalence, persistence, and association with concurrent cervical infection, in Chilean women.Methods1021 women from the general population, aged 15–85 years, were studied in 2001 of whom 600 were reexamined in 2006. The assessments at both time points included cervical HPV DNA testing, HPV antibody testing, cervical cytology and a sociodemographic/behavioral questionnaire. HPV DNA and antibodies against L1 protein of types 16, 18, 31, 33, 35, 45, 52, and 58 were assessed by reverse line blot and multiplex serology, respectively.ResultsSeropositivity was high at both baseline (43.2%) and follow-up (50.2%) and increased with age (p < 0.001); corresponding DNA prevalences were 6.7% and 8.7%. DNA and seroprevalence were associated at baseline (p = 0.01 for any HPV). Early age at first sexual intercourse and having had two or more sexual partners were independently associated with seropositivity. Most (82.0%) initially seropositive women remained seropositive at follow-up; 21.6% of initially seronegative women seroconverted, reaching 17.5% among women older than 60 years of age. ASCUS or worse cytology was correlated with HPV DNA positivity but not with HPV seropositivity.ConclusionHPV seroprevalence studies are a useful tool for learning about the dynamics of HPV infection in a community. This study contributes to understanding the natural history of HPV infection and provides a baseline assessment before the incorporation of HPV vaccination into a national program.

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Section: Discussionsupporting

confidence: 88%

Serological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chile

et al. 2014

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“…Therefore, there is a need for health professionals to provide balanced information about HPV and the HPV vaccination—including the benefits and limitations of the latter—to adolescents and their parents. Strong opinions based on previous studies are that vaccination against HPV should be undertaken in early adolescence, prior to sexual debut, and that an HPV vaccine program should be incorporated into the school vaccination program [ 36 , 37 ]. The role of parents in this issue was not examined in the present study.…”

Section: Discussionmentioning

confidence: 99%

Awareness of human papillomavirus and factors associated with intention to obtain HPV vaccination among Korean youth: quasi experimental study

Kim

2015

BMC Int Health Hum Rights

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BackgroundThis study aimed to determine the awareness among fifth-grade girls and boys of sexually transmitted diseases (STDs), cancer, and human papillomavirus (HPV), and to determine the factors associated with intention to obtain the HPV vaccination.MethodsA quasi experimental design was employed with Korean fifth-grade students as the subjects for this study (n=117). Prior to providing HPV education, the awareness and health beliefs regarding STDs and cancer prevention were assessed according to gender. After 2 hours of HPV education, gender comparisons were made with respect to the awareness and health beliefs, HPV knowledge, and intention to obtain the HPV vaccination, and the factors associated with that intention.ResultsPrior to the 2hours education session, only two boys knew that HPV is a virus. There were significant gender differences with respect to responses to the statements “STD is preventable” (χ2=8.76, p=0.013) and “cancer is preventable” (χ2=6.37, p=0.041), and concerns about the pain associated with vaccine injection (z=−2.44, p=0.015). After HPV education, there were no significant gender differences in HPV knowledge and intention to obtain the HPV vaccination. Awareness that “HPV vaccine can prevent cervical cancer” was significantly related to intention to obtain the HPV vaccine among both boys and girls.ConclusionsIncreased HPV knowledge could positively influence the intention to obtain the HPV vaccination among youth. Thus, HPV education at elementary school would be helpful to make students aware of HPV and the importance of HPV prevention.Electronic supplementary materialThe online version of this article (doi:10.1186/s12914-015-0042-2) contains supplementary material, which is available to authorized users.

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“…Few studies have focused on low-resource areas, such as Central and South America (7,(15)(16)(17), Asia (5,18) or Africa (19), where the highest HPV DNA prevalence in the world can be found, notably among middleaged women (20).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Antibodies against Human Papillomavirus (HPV) Types 16 and 18 in Four Continents: the International Agency for Research on Cancer HPV Prevalence Surveys

Vaccarella

Franceschi²,

Clifford³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Few human papillomavirus (HPV) seroprevalence studies have been carried out in women from low-resource countries.Methods: Seroprevalence of antibodies against HPV16 and HPV18 was assessed in 7,074 women ≥15 years of age (median 44 years) from eight world areas. Serum antibodies against HPV16 and HPV18 were tested for using enzyme-linked immunosorbent assay. HPV DNA was assessed using a general primer GP5 +/6+-mediated PCR.Results: HPV16 and HPV18 seroprevalence both ranged from <1% (Hanoi, Vietnam) to ≥25% (Nigeria). Of women who were HPV16 or HPV18 DNA-positive, seropositivity for the same type was 39.8% and 23.2%, respectively. Seropositivity for either type was directly associated with markers of sexual behavior. HPV16 and/or 18 (HPV16/18)-seropositive women had an increased risk of having cytologic abnormalities only if they were also HPV DNA-positive. A high international correlation was found between HPV16/18 seroprevalence and overall HPV DNA prevalence (r = 0.81; P = 0.022). However, HPV16/18 seroprevalence was substantially higher than the corresponding DNA prevalence in all study areas (although to different extents) and, contrary to DNA, tended to increase from young to middle age, and then decline or remain fairly constant. In all study areas, the vast majority of the information on the burden of exposure to HPV16/18 derived from serology.Conclusions: The correlation between HPV DNA and HPV serology was not very good at an individual woman level, but high at a population level.Impact: HPV serology is a poor marker of current infection or related lesions, but it can contribute, together with DNA, in evaluating the variations in the burden of HPV infection worldwide. Cancer Epidemiol Biomarkers

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Seroprevalence and Risk Factors for Human Papillomavirus in Taiwan

Cited by 10 publications

References 14 publications

Serological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chile

Serological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chile

Awareness of human papillomavirus and factors associated with intention to obtain HPV vaccination among Korean youth: quasi experimental study

Seroprevalence of Antibodies against Human Papillomavirus (HPV) Types 16 and 18 in Four Continents: the International Agency for Research on Cancer HPV Prevalence Surveys

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