Seroprevalence and Risk Factors for Herpes Simplex Virus Infection in a Population of HIV-Infected Patients in Canada

Romanowski, Barbara; Myziuk, Linda; Walmsley, Sharon; Trottier, Sylvie; Singh, Ameeta E.; Houston, Stanley; Joffe, Mark; Chiu, Isabelle

doi:10.1097/olq.0b013e31818d3fb6

Cited by 28 publications

(26 citation statements)

References 31 publications

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“…Serological evidence of HSV-2 infection was common in all groups in our study and was asymptomatic in most people, as in other studies (Romanowski et al, 2009). Hepatitis C was the only infection that was more common in heterosexual men and women than in MSM, even amongst those who reported no recent history of injection drug use.…”

Section: Discussionsupporting

confidence: 90%

Sexually transmitted infections in HIV-infected people in Switzerland: cross-sectional study

Sprenger

Evison

Zwahlen

et al. 2014

PeerJ

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Sexually transmitted infections (STI) in HIV-infected people are of increasing concern. We estimated STI prevalence and sexual healthcare seeking behaviour in 224 sexually active HIV-infected people, including men who have sex with men (MSM, n = 112), heterosexual men (n = 65) and women (n = 47). Laboratory-diagnosed bacterial STI were more common in MSM (Chlamydia trachomatis 10.7%; 95% CI 6.2, 18.0%, lymphogranuloma venereum 0.9%; 95% CI 0.1, 6.2%, Neisseria gonorrhoeae 2.7%; 95% CI 0.9, 8.0%, syphilis seroconversion 5.4%; 95% CI 2.0, 11.3%) than heterosexual men (gonorrhoea 1.5%; 95% CI 0.2, 10.3%) or women (no acute infections). Combined rates of laboratory-diagnosed and self-reported bacterial STI in the year before the study were: MSM (27.7%; 95% CI 21.1, 36.7%); heterosexual men (1.5%; 95% CI 0.2, 10.3%); and women (6.4%; 95% CI 2.1, 21.0%). Antibodies to hepatitis C virus were least common in MSM. Antibodies to herpes simplex type 2 virus were least common in heterosexual men. Most MSM, but not heterosexual men or women, agreed that STI testing should be offered every year. In this study, combined rates of bacterial STI in MSM were high; a regular assessment of sexual health would allow those at risk of STI to be offered testing, treatment and partner management.

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Section: Discussionsupporting

confidence: 90%

Sexually transmitted infections in HIV-infected people in Switzerland: cross-sectional study

Sprenger

Evison

Zwahlen

et al. 2014

PeerJ

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“…Most of them are asymptomatic during the initial stage, they remain undiagnosed for long periods of time or even throughout the life. However, the seroprevalence rates of HSV-1 in HIV-positive patients in our study lower than in the other 9,10,18 The high prevalence of HSV-1 IgG antibody in HIV-positive patients than in general population is possibly because many of them were acquired HSV-1 through sexual activities. It is well known that HSV-1 is usually acquired orally during childhood via non-sexual contacts, however the virus can be transmitted also through sexual contacts.…”

Section: Discussioncontrasting

confidence: 46%

“…The prevalence rates of HSV type 1 (HSV-1) among HIV-1 infected people ranging from 90% to 100%. 9,10 HSV-2 prevalence is highly variable and depends on many factors, including country and region of residence, population subgroup, sex, and age. Prevalence of HSV-2 infection in the general population in developing Asian countries appears to be lower (10-30%) than developed regions.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Herpes Simplex virus types 1 and 2 and their association with CD4 count among HIV-positive patients

Sufiawati

Widyaputra

Djajakusumah

2012

Dent. J. (Majalah Kedokteran Gigi)

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Background: Herpes simplex virus (HSV) is a common cause of viral opportunistic infections among HIV t-tests and analysis of variance (ANOVA). Results: There were no significant differences in HSV-1 seroprevalence between HIV-positive patients (71%) and HIV-negative patients (66%). HSV-2 seroprevalence was significantly higher in HIV-positive patients (30%) than HIV-negative patients (5%). The titers of HSV-1 IgG antibodies in HIV-positive patients (mean 24.63 ± 19.06 IDU) were significantly lower than those of HIV-negative patients (mean 44.62 ± 33.22 IDU). In contrast, HSV-2 IgG antibody titers in HIV-positive patients (mean 13.31 ± 20.28 IDU) were significantly higher than HIV-negative patients (mean 4.42 ± 10.99 IDU)

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“…Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection (STI) in PHAs with a lifetime prevalence ranging from 30% to 70% in the United States, Canada and Europe and 50% to 90% in Africa (Ameli et al, 2006;Andréoletti et al, 2005;Cachay, Frost, Richman, Smith, & Little, 2007;Corey, Adams, Brown, & Holmes, 1983;Kapiga et al, 2007;Nahmias, Lee, & Beckman-Nahmias, 1990;Ramaswamy et al, 2006;Romanowski et al, 2009;Smith & Robinson, 2002;Suligoi et al, 2002;van Benthem et al, 2001;Xu et al, 2006). Compared to men, women are almost three times more likely to be sero-positive for HSV-2 (Romanowski et al).…”

Section: Introductionmentioning

confidence: 97%

HSV-2/HIV co-infection, health-related quality of life and identity in women

Ion

Greene

MacMillan

et al. 2013

The Canadian Journal of Human Sexuality

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This qualitative study sought to understand the meaning that women ascribe to living with HIV and symptomatic HSV-2 infections in relationship to their health-related quality of life (HRQoL). HIV affected overall physical and mental HRQoL whereas HSV-2 was an immediate concern experienced on an episodic basis. HSV-2/HIV co-infection was framed as a gendered issue affecting women's abilities to navigate social and sexual relationships and assume social roles. Participants outlined several approaches to overcome their diagnoses and described several social and structural barriers that prevented achieving good HRQoL. HSV-2 is an important medical and psychosocial issue for women living with HIV. Implications for practice and pedagogy are discussed.

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Seroprevalence and Risk Factors for Herpes Simplex Virus Infection in a Population of HIV-Infected Patients in Canada

Cited by 28 publications

References 31 publications

Sexually transmitted infections in HIV-infected people in Switzerland: cross-sectional study

Sexually transmitted infections in HIV-infected people in Switzerland: cross-sectional study

Seroprevalence of Herpes Simplex virus types 1 and 2 and their association with CD4 count among HIV-positive patients

HSV-2/HIV co-infection, health-related quality of life and identity in women

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