Seroprevalence and Risk Factors for Severe Fever with Thrombocytopenia Syndrome Virus Infection in Jiangsu Province, China, 2011

Liang, Shuyi; Bao, Changjun; Zhou, Minghao; Hu, Jianli; Tang, Fenyang; Guo, Xiling; Jiao, Yongjun; Zhang, Wenshuai; Luo, Peng; Li, Luxun; Zhu, Kuanyuan; Tan, Winston; Lu, Qimei; Ge, Heng-Ming; Chen, Abao

doi:10.4269/ajtmh.13-0423

Cited by 50 publications

(44 citation statements)

References 10 publications

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“…The positive rate in this study was similar to the reported percentage (3.3%) recorded in Shandong Province 14 . However, it was much higher than that reported in Jiangsu (0.44%), lower than that in Shanxi (4.7%) 15,16 . The discrepancy may be attributed to the season of collection, population size, geographic climatic factors and different methods.…”

Section: Discussioncontrasting

confidence: 66%

Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China

Shao

et al. 2018

Sci Rep

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) in East Asia. The research on seroprevalence of SFTSV in healthy people and risk factors had been detailed. However, the levels of neutralizing antibodies against SFTSV in general population were currently unclear. In the present study, we tested 1375 healthy persons from Penglai County, eastern China, for SFTSV neutralizing antibodies; 0.58% (8/1,375) was positive and the positive rates were not significantly different among people at different age groups, occupations and genders. Besides, a follow-up study was conducted and the titer of neutralizing antibodies decreased over time in all eight people but one, and the neutralizing antibodies of five lasted for the entire study period of seven years. Our results suggesting that subclinical infection or a relatively mild form of SFTS illness is occurring in this population, but a small percentage of sera have neutralizing capacity to SFTSV. Hence, most people are just susceptible to SFTSV infection.

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Section: Discussioncontrasting

confidence: 66%

Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China

Shao

et al. 2018

Sci Rep

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“…26 An epidemiological study further implicated goat ownership and exposure to Haemaphysalis longicornis ticks as risk factors for SFTSV infection in Jiangsu Province, China. 10 Goats were not assessed for HRTV-neutralizing antibodies in this study as this species of domesticated animal was absent in our study sites.…”

Section: Discussionmentioning

confidence: 97%

“…7 HRTV is genetically most closely related to a recently discovered tick-borne virus infecting humans in China known as severe fever with thrombocytopenia syndrome virus (SFTSV), 1,8,9 which is believed to be acquired by larval ticks feeding on viremic domestic farm animals, transstadially passaged to the nymphal stage and transmitted to humans by blood-feeding nymphs. 10 Because of the tick exposures reported by both of the original human cases in 2009, 1 the detection of HRTV-infected nymphal ticks in 2012 from one of the human case residences and a nearby conservation area, 7 and the tick-associated transmission of the closely related SFTS virus, 11 HRTV was presumed to be maintained by ticks and nonhuman vertebrate amplification host(s). The lone star tick, the putative vector, is known to feed on a wide range of medium-and large-sized vertebrate hosts.…”

Section: Introductionmentioning

confidence: 99%

Serological Investigation of Heartland Virus (Bunyaviridae: Phlebovirus) Exposure in Wild and Domestic Animals Adjacent to Human Case Sites in Missouri 2012–2013

Bosco‐Lauth¹,

Panella²,

Root³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.

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“…Because the primary mode of transmission by which SFTSV infects humans is a bite by a SFTSV-infected tick, an occupational risk was noted for individuals working in farms as well as for those in contact with domestic and/or wild animals (12)(13)(14). SFTSV is known to circulate in Japan because patients with SFTS are being notified (6) because the SFTSV genome is detected in several tick species and a high prevalence of anti-SFTSV antibody seropositivity was observed among deer, wild boars, dogs, and raccoon dogs (15).…”

Section: Discussionmentioning

confidence: 99%

Low Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Antibodies in Individuals Living in an Endemic Area in Japan

et al. 2018

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SUMMARY:Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infection with a high mortality rate. It is caused by the SFTS virus (SFTSV) and is endemic in some areas in western Japan, including the Kagoshima prefecture. In the present study, healthy individuals living in this prefecture were examined to assess for anti-SFTSV seroprevalence. An initial study was performed using the serum samples collected from a total of 646 individuals living in Kagoshima. At the same time, a questionnaire was used to collect information (such as occupation and a history of tick bite). Enzyme-linked immunosorbent assay and indirect immunofluorescence assay were used for the screening. Finally, the seroprevalence of anti-SFTSV antibodies was confirmed using a neutralization assay. Only 2 (0.3%) out of 646 study participants were positive for anti-SFTSV antibodies. No significant difference was observed between individuals who are at a high or low risk of tick bite in terms of seropositivity. Next, a total of 1,000 serum samples collected from general blood donors by the Japanese Red Cross Kyushu Block Blood Center were tested. None of these samples tested positive for anti-SFTSV antibodies. These results suggest a low seroprevalence of anti-SFTSV antibodies in healthy individuals living in an endemic area in Japan.

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Seroprevalence and Risk Factors for Severe Fever with Thrombocytopenia Syndrome Virus Infection in Jiangsu Province, China, 2011

Cited by 50 publications

References 10 publications

Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China

Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China

Serological Investigation of Heartland Virus (Bunyaviridae: Phlebovirus) Exposure in Wild and Domestic Animals Adjacent to Human Case Sites in Missouri 2012–2013

Low Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Antibodies in Individuals Living in an Endemic Area in Japan

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