Seroprevalence and Potential Risk Factors of Hepatitis E Virus among Pregnant Women in Khartoum, Sudan

Mustafa, Alaa Abdulrahman Mohammad; Abdalla, Wafaa Mohammed; Ahmed, Hind Haidar; Saeed, Samar M.; Ismail, Ahmed; Khalifa, Sarrah Elnoor; AbdAlla, Ahmed Bakheet; Ahmed, Tagwa Salah; Junaid, Kashaf

doi:10.22207/jpam.16.1.57

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…19 Another similar study from China, 6.0% of pregnant women were positive for anti-HEV IgG antibody, 0.3% were anti-HEV IgM antibody positive and 0.3% were positive for both anti-HEV IgG and anti-HEV IgM antibodies, which was well in concordance with our study. 20 Mustafa et al 21 in their study reported high prevalence of 40% for IgG antibodies and 6% positive for IgM antibodies, access to healthy food and clean water is almost impossible for study participants. Such conditions provide a great environment for disease.…”

Section: Discussionmentioning

confidence: 91%

Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Riyaz¹,

Umadevi²,

S³

et al. 2023

J. Pure Appl. Microbiol.

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Hepatitis E virus (HEV) is the most common cause of AVH in developing countries. HEV causes a self-limiting infection that is transmitted mainly through the consumption of contaminated food and water. Our study aimed to find out the seroprevalence of HEV infection. Detected both IgG & IgM antibodies from 100 asymptomatic antenatal women. ELISA (DIA PRO, Italy) was used to detect antibodies. Seropositivity was found in 9% of pregnant women, all might have been exposed to HEV infection previously. It could be unnoticed due to its self-limiting nature. IgG was 5% and IgM was 6%. Both IgM & IgG were detected in two pregnant women. Untreated water was used by the majority of women irrespective of their educational status. Though it is a self-limiting disease, it is necessary to screen for its antibody. Awareness about the modes of transmission & complications needs to be addressed in the community. It is necessary to do further studies for screening for HEV infection as there is a very limited number of studies published from South India.

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Section: Discussionmentioning

confidence: 91%

Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Riyaz¹,

Umadevi²,

S³

et al. 2023

J. Pure Appl. Microbiol.

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“…Hospital-based research conducted during a Delhi outbreak found that HEV infection during pregnancy was linked to perinatal death, stillbirth, or miscarriage in 56% of cases. According to a recent study, antenatal maternal deaths are often linked to additional fetal deaths, and in developing countries, HEV infection may cause 2400-3000 stillbirths each year [45]. Pregnant women with HEV infection have a high risk of preterm delivery and poor neonatal survival rates.…”

Section: Incidence Rate Of Hev In Pregnant Femalesmentioning

confidence: 99%

Hepatitis E Virus: Epidemiology, Clinical Aspects, and Its Significance as a Major Pregnancy Risk

Urooj,

Anjum,

Iqbal

et al. 2023

Livers

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HEV is a single-stranded, positive RNA virus. The hepatitis E virus (HEV) is the causing agent of hepatitis, with a high prevalence rate in low-income countries due to poor sanitary conditions. It can exhibit acute, continuous, or extrahepatic consequences in immunocompromised individuals such as those undergoing organ transplantation and having HIV infection. HEV infection is either self limiting (silent), meaning the patient will possibly recover on his own, or symptomatic, causing acute liver injury or fulminant hepatitis and may eventually cause death. It can also cause chronic hepatitis that can progress to cirrhosis or recovery. Pregnancy-related HEV infection has an incidence rate of 30%. HEV escape from innate immunity, hormonal imbalances, defective monocyte–macrophage function, downregulation of the T-cell-mediated immune system, high cytokine production, nutritional factors, and socioeconomic conditions may play fundamental roles in the prevalence of HEV infection. It is necessary to take particular measures to reduce the incidence burden of HEV infection in high endemic locations as the incidence data, not the prevalence data, is more accurate at estimating disease dynamics. The purpose of this study is to throw light on several aspects of the hepatitis E virus and to discuss the incidence of HEV infection concerning other diseases. HEV molecular features, clinical features, epidemiology, extrahepatic manifestations, and multiple available diagnostics and treatment strategies for HEV are debated in the current review.

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Seroprevalence and Potential Risk Factors of Hepatitis E Virus among Pregnant Women in Khartoum, Sudan

Cited by 2 publications

References 32 publications

Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry

Hepatitis E Virus: Epidemiology, Clinical Aspects, and Its Significance as a Major Pregnancy Risk

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