Seropositivity for the human heat shock protein (Hsp)60 accompanying seropositivity for Chlamydia trachomatis is less prevalent among tubal ectopic pregnancy cases than individuals with normal reproductive history

Özyürek, Eser Şefik; Karacan, Tolga; Ozdalgicoglu, Cenk; Yilmaz, Salih; Işık, Salman; San, Mevlide; Kaya, Erdal

doi:10.1016/j.ejogrb.2018.02.022

Cited by 4 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent research studies have shown a strong association between antibody action to the chlamydia heat shock protein 60 (CHSP60) and ectopic pregnancy [16]. Furthermore, seropositivity to human HSP60 decreases the chance for ectopic gestation in individuals with previous chlamydial infection [17], along with the advancement of chlamydia-associated tubal infertility [18].…”

Section: Introductionmentioning

confidence: 99%

A Prospective Study to Analyze the Specificity of Chlamydial Heat Shock Protein (Chsp60) Antibodies to Diagnose Tubal Infertility

et al. 2021

View full text Add to dashboard Cite

The aim: To investigate the utility of testing for chlamydial heat shock protein 60 (CHSP60) antibodies in the diagnosis of tubal infertility. Materials and methods: All the collected samples were assayed for IgM and IgG antibodies to chlamydia trachomatis and chlamydial heat shock protein 60 (CHSP60) by using immunofluorescence and enzyme-linked immunosorbent assay (ELISA) techniques, respectively. Results: There were no substantial differences between antibodies to C. trachomatis in females with tubal infertility (67%) and non-tubal infertility (48%). However, women with tubal infertility (45%) have more anti-CHSP60 antibodies than non-tubal infertility (9%). Antibody screening for C. trachomatis has only (63%) sensitivity and (54%) specificity for detecting tubal infertility. On the other hand, the CHSP60 antibody testing has (44%) sensitivity and 92% specificity for diagnosing tubal infertility. A positive microimmunofluorescence (MIF) titer was observed in 12 of 18 (67%) females with the tubal problem, 31 of 64 (48%) with non-tubal infertility (P=0.3, OR=2.2, 95% CI=0.71 to 8.01). The CHSP60 antibodies were found in 8 of 18 (45%) females with tubal problem & 6 of 64 (9%) women with non-tubal infertility, power factor alpha α P=0.004, OR=9.3, 95% CI=2.1 to 43.2, power= 1.002 for n= 0.05). Incorporating CHSP60 and C. trachomatis antibodies testing gives an excellent positive probability proportion of 10 to diagnose C. trachomatis associated tubal infertility. Conclusions: CHSP60 antibody testing is a more specific evaluation than antibody testing for C. trachomatis for predicting chlamydia-associated tubal infertility. Using these tests at the first infertility examination may help the immediate diagnosis for non-interceptive tubal infertility.

show abstract

Section: Introductionmentioning

confidence: 99%

A Prospective Study to Analyze the Specificity of Chlamydial Heat Shock Protein (Chsp60) Antibodies to Diagnose Tubal Infertility

et al. 2021

View full text Add to dashboard Cite

show abstract

Relation of Chlamydia trachomatis infections to ectopic pregnancy

et al. 2020

View full text Add to dashboard Cite

Background: In a multitude of previous studies, Chlamydia trachomatis (CT) plays an important role in the occurrence of ectopic pregnancy (EP). However, the predictive value of CT infections in the occurrence of EP has not been estimated worldwide. We thus evaluated, by means of a meta-analysis, the current status of the association between CT infections with EP and the potential predictive value of CT infections in EP. Methods: We evaluated studies performed between the database construction time and August 2018 published in PubMed, the Cochrane Library, EMBASE, and the Web of Science (SCI). The relationship between CT and EP was calculated based upon the predetermined entry criteria for control group selection and the original data. The related articles were analyzed using a random-effects model, and the heterogeneity of the studies was assessed using the I2 index. Data were analyzed with the STATA 12.0 software. Results: Twenty-five studies that recruited 11960 patients were included in the present meta-analysis, and the relation of CT infections with EP were assessed. The association between CT infections and EP risk showed an odds ratio (OR) of 3.03, with a 95% confidence interval (CI) of 2.37 to 3.89. Our results showed that there was a statistically significant difference between the intervention and control groups. The prevalence of CT infections in EP was then calculated by a subgroup analysis: African (OR, 2.22; 95% CI, 1.14–4.31), European (OR, 3.16; 95% CI, 2.10–4.47), North American (OR, 3.07; 95% CI, 1.78–5.31), and Asian (OR, 3.39; 95% CI, 1.95–5.90). Conclusions: From the results of numerous studies conducted on different continents, this meta-analysis showed a clear association between EP and prior CT infections, that is, CT infections increase the risk of EP occurrence.

show abstract

Evaluation of Hsp70 Levels in Ectopic Pregnancy, Abortus Imminens and Intrauterine Pregnancy

et al. 2022

View full text Add to dashboard Cite

Aim: To assess the serum levels of HSP70 concentrations in ectopic pregnancy (EP) patients compared with abortus imminens (AI) patients and healthy controls. Materials & methods: Age-matched patients were divided into three groups, with 30 patients in each group: EP, AI and healthy intrauterine pregnancy groups. Blood samples were taken from the antecubital vein and kept for HSP70 analysis. Results: The HSP70 levels were higher in the EP group than in AI patients and healthy controls (p < 0.05). The area under the curve for the serum HSP70 assay reached a value of 0.81 for a cutoff point of 11.12 pg/ml, which identified women with EP. Conclusion: Serum HSP70 levels increased in women with EP compared with healthy controls and women with AI.

show abstract

Seropositivity for the human heat shock protein (Hsp)60 accompanying seropositivity for Chlamydia trachomatis is less prevalent among tubal ectopic pregnancy cases than individuals with normal reproductive history

Cited by 4 publications

References 25 publications

A Prospective Study to Analyze the Specificity of Chlamydial Heat Shock Protein (Chsp60) Antibodies to Diagnose Tubal Infertility

A Prospective Study to Analyze the Specificity of Chlamydial Heat Shock Protein (Chsp60) Antibodies to Diagnose Tubal Infertility

Relation of Chlamydia trachomatis infections to ectopic pregnancy

Evaluation of Hsp70 Levels in Ectopic Pregnancy, Abortus Imminens and Intrauterine Pregnancy

Contact Info

Product

Resources

About