Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea

Kim, Hyunsuk; Ryu, Jiwon; Lee, Young-Ki; Choi, Moon-Gi; Cho, Ajin; Koo, Ja‐Ryong; Baik, Sae Yun; Lee, Eun Hee; Yoon, Jong‐Woo; Noh, Jung‐Woo

doi:10.3904/kjim.2017.293

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…People born after 1980, when the environment was cleaner and the HAV vaccine was yet developed, have been reported to be more susceptible to HAV (25,26). Other similar studies on the seroprevalence of HAV antibodies have been reported steadily over time (27)(28)(29)(30).…”

Section: Introductionmentioning

confidence: 53%

Investigating the spatio-temporal variation of hepatitis A in Korea using a Bayesian model

Jeong

Choi²

2023

Front. Public Health

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Hepatitis A is a water-borne infectious disease that frequently occurs in unsanitary environments. However, paradoxically, those who have spent their infancy in a sanitary environment are more susceptible to hepatitis A because they do not have the opportunity to acquire natural immunity. In Korea, hepatitis A is prevalent because of the distribution of uncooked seafood, especially during hot and humid summers. In general, the transmission of hepatitis A is known to be dynamically affected by socioeconomic, environmental, and weather-related factors and is heterogeneous in time and space. In this study, we aimed to investigate the spatio-temporal variation of hepatitis A and the effects of socioeconomic and weather-related factors in Korea using a flexible spatio-temporal model. We propose a Bayesian Poisson regression model coupled with spatio-temporal variability to estimate the effects of risk factors. We used weekly hepatitis A incidence data across 250 districts in Korea from 2016 to 2019. We found spatial and temporal autocorrelations of hepatitis A indicating that the spatial distribution of hepatitis A varied dynamically over time. From the estimation results, we noticed that the districts with large proportions of males and foreigners correspond to higher incidences. The average temperature was positively correlated with the incidence, which is in agreement with other studies showing that the incidences in Korea are noticeable in spring and summer due to the increased outdoor activity and intake of stale seafood. To the best of our knowledge, this study is the first to suggest a spatio-temporal model for hepatitis A across the entirety of Korean. The proposed model could be useful for predicting, preventing, and controlling the spread of hepatitis A.

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Section: Introductionmentioning

confidence: 53%

Investigating the spatio-temporal variation of hepatitis A in Korea using a Bayesian model

Jeong

Choi²

2023

Front. Public Health

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“…[7] This phenomenon is associated with low seroprevalence of anti-HAV IgG in a specific age group. [8,9] To prevent hepatitis A infection in South Korea, national vaccination programs have been implemented in the military since 2012 and in toddlers since 2015. [10,11] However, there are insufficient preventive measures for people in their 20s, 30s, and 40s, and they are the main age group for recent outbreaks.…”

Section: Dhl and Ws Contributed Equally To This Articlementioning

confidence: 99%

“…[7] This phenomenon is associated with low seroprevalence of anti-HAV IgG in a specific age group. [8,9]…”

Section: Introductionmentioning

confidence: 99%

The chronological changes in the seroprevalence of anti-hepatitis A virus IgG from 2005 to 2019: Experience at four centers in the capital area of South Korea

et al. 2022

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Although universal vaccination has been administered to toddlers, South Korea has had periodic nationwide outbreaks of acute hepatitis A since the late 2000s. We examined the chronological changes in the seroprevalence of anti-hepatitis A virus (HAV) immunoglobulin G (IgG) over the past 15 years (2005–2019). We retrospectively collected data from 45,632 subjects who underwent anti-HAV IgG testing without evidence of acute HAV infection at four centers in the capital area of South Korea between January 2005 and December 2019. The seroprevalence of anti-HAV IgG was analyzed according to age and compared among seven age groups and five time periods. Additionally, age-period-cohort analyses were used to identify the age, period, and cohort effects of the seroprevalence of anti-HAV IgG. The mean age of the enrolled subjects was 39.2 ± 19.2 years, and the average anti-HAV IgG positivity rate was 66.4%. During the 15 years, the seroprevalence of anti-HAV IgG in people aged 0 to 19 years significantly increased over time (P < .001). In people aged 20 to 29 years, the seroprevalence slightly decreased to that of the early 2010s (31.3% in 2005–2007 to 19.7% in 2011–2013) but rebounded to 39.5% in 2017 to 2019. In contrast, the seroprevalence of anti-HAV IgG in those aged 30 to 49 years decreased over time (P < .001). The seroprevalence of anti-HAV IgG in those aged 20 to 39 years in 2017 to 2019 was still less than 40%. In addition, the seroprevalence of anti-HAV IgG in people aged 50 to 59 years has recently decreased. Since the introduction of the universal vaccination, the seroprevalence of anti-HAV IgG in children and young adults has gradually increased. However, the seroprevalence of anti-HAV IgG in people in their 20s remains low, and the seroprevalence of anti-HAV IgG in people in their 30s and 40s is gradually decreasing. Therefore, a new strategy for HAV vaccination is needed for those in their 20s to 40s.

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Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea

Abstract: The seropositive rate of the anti-HAV antibody in hemodialysis subjects was 95%, which is similar to findings in the general population. Active immunization against hepatitis A is strongly recommended for hemodialysis subjects under 40 years of age after anti-HAV testing.

Cited by 2 publications

References 20 publications

Investigating the spatio-temporal variation of hepatitis A in Korea using a Bayesian model

Investigating the spatio-temporal variation of hepatitis A in Korea using a Bayesian model

The chronological changes in the seroprevalence of anti-hepatitis A virus IgG from 2005 to 2019: Experience at four centers in the capital area of South Korea

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