Seronegative disease after inadequate therapy in lyme arthritis: Comment on the article by Kannian et al

Abstract

Churg-Strauss syndrome as part of their definition of ANCAassociated vasculitis, the title is misleading. This highlights one of the many problems with the terminology "ANCA-associated vasculitis" and the advantages of considering these as separate diseases, particularly within therapeutic trials.We do not think that these data lend any additional support for the use of IVIGs in WG and MPA. Although randomized, double-blind, controlled studies would be needed to determine effectiveness, the available data raise questions as to whether IVIG treatment warrants additional investigation in place of emerging therapies.

Ankle Arthritis in a 6-Year-Old Boy After a Tick Bite – A Case Report

“…This treatment may have hindered the antibody production against B burgdorferi , while not being therapeutic, due to the short duration. Seronegative Lyme arthritis due to early and inadequate antibiotic treatment has been reported by several authors [2-5]. Chronic Lyme disease cannot be excluded by the absence of antibodies against B. burgdorferi [6].…”

Reply to letter by Volkman commenting on the possible onset of seronegative disease in Lyme arthritis

“…We read with interest the article in which Prelog et al present robust evidence of increased naive T cell proliferation in patients with juvenile idiopathic arthritis (JIA) (1). The authors propose that this proliferation may be driven by 310 …”