Seronegative coeliac disease in the light of the guidelines by the European Society for the Study of Coeliac Disease (ESsCD) 2019

Shapovalova, N.S.; Novikova, V.P.; Ревнова, М. О.; Kalinina, Elena; Belmer, S.V.; Хавкин, А.И.

doi:10.20953/1727-5784-2019-6-14-22

Cited by 6 publications

(3 citation statements)

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“…Однако определение интестинальных белков, вероятно, имеет значение в комбинации с определением цитруллина. Плазменный цитруллин является также одним из наиболее интересных биомаркеров [42][43][44][45]. Несколько исследований показали, что цитруллин возможно измерить в животных моделях, у взрослых пациентов и педиатрических больных.…”

Section: заключениеunclassified

Perspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damage

Хавкин

Новикова

Shapovalova

2021

jour

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The aim of this literature review was to consider the diagnostic value of potential biomarkers detection: citrulline and intestinal proteins, designed to detect intestinal mucosa damage.Conclusion: determination of I-FABP and I-BABP in blood are promising methods for non-invasive diagnosis of the intestinal damage, since these proteins are released from the damaged enterocytes. However, the determination of intestinal proteins is important in combination with the determination of citrulline. Several studies have shown that citrulline can be measured in animal models, in adult and pediatric patients. It is easily detectable, consistently measured and capable of detecting inflammation of the intestinal mucosa. The limitation of most studies was the small sample size. Non-invasive diagnostic and therapeutic monitoring techniques remain an important area of further research.

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Section: заключениеunclassified

Perspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damage

Хавкин

Новикова

Shapovalova

2021

jour

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“…Задержка диагностики целиакии у детей с нормальной или повышенной массой тела может способствовать развитию долгосрочных неблагоприятных последствий для здоровья. Диагноз целиакии не следует исключать, если у пациента нормальный или высокий BMI [30][31][32][33].…”

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Celiac disease and obesity: the possibility of comboridity of pathology in children

Novikova¹,

Грицинская²,

Хавкин

2021

jour

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The article presents an analytical review of scientific research on celiac disease in children in different countries of the world. The prevalence of atypical manifestations of celiac disease has increased over the past two decades. A number of studies in children with celiac disease show that overweight / obesity at the onset of the disease is not uncommon. In addition, there is a tendency to develop overweight / obesity in patients with celiac disease who strictly adhere to a gluten-free diet. It has been shown that among obese children, the prevalence of celiac disease is comparable to the general population frequency. Thus, the diagnosis of celiac disease should be considered even in children with overweight / obesity, when this diagnosis can be easily missed.

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“…В частности, исследования на животных продемонстрировали, что изменения диеты и сопутствующие изменения микробиоты оказывают существенное влияние на поведение крыс [56,57]. Tillisch K. et al показали, что употребление здоровыми женщинами молочного напитка, обогащенного пробиотиками, способствовало изменению активности определенных участков головного мозга, ответственных за контроль над эмоциями и ощущениями [55,58,59].…”

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Gluten-free diet for neurological and psychiatric diseases: is it worth expecting an effect?

Дмитриева

Захарова

Радченко³

et al. 2021

jour

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Gluten represents an alcohol- soluble fraction of endosperm proteins of some cereals (wheat, rye, barley). The molecular characteristics of gluten, in particular, the high content of proline in the composition, determines its high resistance to human gastric, pancreatic and intestinal enzymes. Accordingly, gluten peptides retain their immunogenicity when they enter the internal environment of the body, which determines their ability to activate both the innate and adaptive immune response, and maintain pathological immune- mediated reactions that underlie the complex of gluten- associated diseases and pathological conditions. The question of how gluten consumption may be associated with various neurological disorders continues to be discussed. Despite the lack of sufficient objective evidence, the peculiarities of gliadin metabolism suggest the possibility of an association between the consumption of gluten- containing products with the development of neuropsychiatric disorders.. Of particular interest is the efficacy of gluten-free diet in the complex therapy of such diseases as autism, schizophrenia, as well as some neurological disorders, including chronic fatigue syndrome, various cognitive impairments, depression, etc. The article presents a number of research results, as well as discusses the potential mechanisms of the neurotropic action of gluten. The article discusses the potential metabolic and immunological mechanisms of the neurotropic action of gluten, analyzes the literature data regarding the effectiveness of a gluten-free diet in various neurological diseases and psychiatric disorders.

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Seronegative coeliac disease in the light of the guidelines by the European Society for the Study of Coeliac Disease (ESsCD) 2019

Cited by 6 publications

References 0 publications

Perspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damage

Perspective non-invasive biomarkers: intestinal proteins in the diagnosis for diagnosis and control of intestinal mucosal damage

Celiac disease and obesity: the possibility of comboridity of pathology in children

Gluten-free diet for neurological and psychiatric diseases: is it worth expecting an effect?

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