Seroma Change during Magnetic Resonance Imaging-Guided Partial Breast Irradiation and Its Clinical Implications

Abstract

Background: To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast irradiation (PBI). Methods: MRI data obtained from 37 women with early breast cancer acquired at simulation and at the 1st, 6th, and 10th fractions were analyzed. The planning target volume (PTV) was defined as unequal margins of 10-15 mm added according to the directional surgical margin status of each seroma. Treatment was performed using a 0.35 T MRI-guided radiotherapy system. Univariate analysis was performed to assess the correlations between SV change rate and clinical factors. Seroma and PTV for adaptive planning were based on the images obtained at the 6th fraction.

Use of magnetic resonance image‐guided radiotherapy for breast cancer: a scoping review

“…The study selection process is outlined in Figure 1. The majority of these studies were retrospective ( n = 10) from the Netherlands, Iran, Korea, USA, Canada and Germany 19‐27 . Two studies were prospective, 12,28 and the same number were longitudinal 6,9 .…”

“…Patients were inclined on breast boards (Thorawedge ® /Macromedics ® ). Jeon et al 25 . simulated patients in supine position using a custom vacuum lockbag for arm elevation plus knee support.…”

“…In Jeon et al.’s study, of their 37 patients, 4 (10.8%) experienced seroma increase during the period between CT and 1st fraction and 33 exhibited a decrease SV over their treatment period. It was advised that no patients’ seroma size increased in the last period of their accelerated schedule, suggesting that adaptive planning on the 6th fraction does not threaten coverage 25 …”

“…The majority of these studies were retrospective ( n = 10) from the Netherlands, Iran, Korea, USA, Canada and Germany. 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 Two studies were prospective, 12 , 28 and the same number were longitudinal. 6 , 9 One position paper was included.…”

“…Patients were inclined on breast boards (Thorawedge â /Macromedics â ). Jeon et al 25 simulated patients in supine position using a custom vacuum lockbag for arm elevation plus knee support. One study positioned a subgroup of patients in the prone position using a CDR prone breast board (Procline TM ).…”