Serology for Helicobacter pylori compared with symptom questionnaires in screening before direct access endoscopy.

Mendall, Michael A.; Jazrawi, R. P.; Marrero, J. M.; Molineaux, N.; Lévi, J.M. Hannoun; Maxwell, J. D.; Northfield, T. C.

doi:10.1136/gut.36.3.330

Cited by 45 publications

(23 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The absence of Helicobacter pylori antibodies of the IgG class, as measured by EIA, is associated with a low probability of ulcer disease [11,12,13,14,15]. Serology-based screening for ulcers has performed better than the usage of questionnaires [14].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serologic Diagnosis of Helicobacter pylori Infection in Outpatients Aged 45 Years or Less

Oksanen

Sipponen

Sarna

et al. 2001

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

The diagnostic accuracy of serological tests for Helicobacter pylori was studied in 145 consecutive outpatients aged 45 years or less referred for gastroscopy. Helicobacter pylori infection can be detected by serological tests, including rapid whole-blood tests. The low prevalence of the disease in young people may have a negative effect on the positive predictive value of a test. In this study, the presence of Helicobacter pylori was assessed by a biopsy urease test and histological examination, and by several serological tests: a rapid whole-blood test on fingerstick blood, a latex agglutination serum test, a commercial enzyme immunoassay (EIA) test, and an in-house EIA for detection of antibodies of both the IgG and IgA classes. Helicobacter pylori infection was diagnosed with invasive tests in 21 (14.5%) patients. The sensitivity, specificity, and positive and negative predictive values of the EIA-based tests, compared to histological examination, were 100%, 96-97%, 81-84%, and 100%, respectively. The positive predictive value of the latex agglutination test was 78%, whereas it was only 47% for the whole-blood rapid test used. Although the results of the whole-blood rapid test were unsatisfactory, the quantitative EIA-based tests could reliably detect Helicobacter pylori among young patients, in whom the prevalence of the infection is low.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Serology-based screening for ulcers has performed better than the usage of questionnaires [14]. However, ulcers may occur even in a small percentage of seronegative patients [10,12,14].…”

Section: Discussionmentioning

confidence: 99%

Serologic Diagnosis of Helicobacter pylori Infection in Outpatients Aged 45 Years or Less

Oksanen

Sipponen

Sarna

et al. 2001

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…Data suggest that administering these questionnaires to young dyspeptic patients and not investigating those with a low probability of significant pathology could halve the number of endoscopies performed. 15 However, many of the questionnaires proposed are too unwieldy for use in general practice and evidence is lacking as to whether results of a questionnaire would sufficiently reassure patients on the absence of significant disease. Such concerns appear justified, as the sensitivity of this strategy is only 80-90% -a proportion of peptic ulcers being missed by symptom questionnaires in prospective studies.…”

Section: Dyspepsia Questionnairesmentioning

confidence: 99%

“…Such concerns appear justified, as the sensitivity of this strategy is only 80-90% -a proportion of peptic ulcers being missed by symptom questionnaires in prospective studies. 15 Symptom questionnaires can therefore enhance the diagnostic accuracy of the clinical history but are probably unsuitable as screening tools to reduce endoscopy workload; they are not considered further in this review.…”

Section: Dyspepsia Questionnairesmentioning

confidence: 99%

The management of dyspepsia: a systematic review.

Delaney

Moayyedi²,

Deeks³

et al. 2000

Health Technology Assessment

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK.We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. Competing interests: R Hobbs is a board member of the European Society of Primary Care Gastroenterology, and has received sponsorship for travel and honoraria from a number of biotechnology and pharmaceutical companies for plenary talks and attendance at major scientific congresses and conferences. HTA Published end of 2000This report should be referenced as follows:Delaney B, Moayyedi P, Deeks J, Innes M, Soo S, Barton P, et al. NHS R&D HTA ProgrammeT he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS.Initially, six HTA panels (pharmaceuticals, acute sector, primary and community care, diagnostics and imaging, population screening, methodology) helped to set the research priorities for the HTA Programme. However, during the past few years there have been a number of changes in and around NHS R&D, such as the establishment of the National Institute for Clinical Excellence (NICE) and the creation of three new research programmes: Service Delivery and Organisation (SDO); New and ...

show abstract

“…The high proportion of normal endoscopies, the high cost and rising demand led investigators to explore means of reducing the number of endoscopic examinations. Structured interviews and questionnaires have been tried, but these have lacked sufficient sensitivity and specificity, and have not been found to be reproducible 11 .…”

Section: Role Of Endoscopy As a Diagnostic Tool In The Management Of mentioning

confidence: 99%

Clinical practice - strategies for management of dyspepsia

Zar

Mendall

1998

British Medical Bulletin

View full text Add to dashboard Cite

Serology for Helicobacter pylori compared with symptom questionnaires in screening before direct access endoscopy.

Cited by 45 publications

References 5 publications

Serologic Diagnosis of Helicobacter pylori Infection in Outpatients Aged 45 Years or Less

Serologic Diagnosis of Helicobacter pylori Infection in Outpatients Aged 45 Years or Less

The management of dyspepsia: a systematic review.

Clinical practice - strategies for management of dyspepsia

Contact Info

Product

Resources

About