Serology and clinical relevance of Corynebacterium pseudotuberculosis in native Korean goats (Capra hircus coreanae)

Abstract

This study was conducted to assess the seroprevalence and clinical relevance of Corynebacterium pseudotuberculosis, which is the causative agent of caseous lymphadenitis (CLA), in native Korean goats (Capra hircus coreanae). A total of 466 native Korean goats from 40 herds (11 to 12 samples per herd) were randomly selected throughout the nation and evaluated by direct palpation, bacterial isolation, ELISA, and PCR. In serological examinations, 267 (57.3 %) of the goats tested were positive against C. pseudotuberculosis. When seroprevalence was analyzed according to age, region, and season, statistically significant differences were observed in relation to all three parameters (P < 0.05). For clinical examination, the superficial lymph nodes of all goats were palpated to diagnose CLA. Pus samples taken from superficial abscesses were used for bacterial isolation. Among the 466 goats tested, 34 (7.3 %) were presumptively diagnosed with CLA, and C. pseudotuberculosis was isolated from 24 goats (70.6 % of goats with CLA lesions) whose infections were confirmed by PCR. Considering the high seroprevalence and bacterial isolation rate from most of the superficial CLA lesions, it is suspected that many internal CLA lesions exist in this goat population. These results suggest that C. pseudotuberculosis infection is widespread in native Korean goats, and appropriate control programs need to be established.

Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work

“…To our knowledge , this is the first documented laborator y transmitted infection by this bacterium. Epidemiological studies among animals have displayed high levels of antibodies towards C pseudotuberculosis [ 29 ], but we do not know whether such tests have been validated for human purposes. If such tests were available, screening of veterinaries, students, laboratory workers, and sheep farmers would be of interest to examine the degree of exposition in such human settings.…”

Utility assessment of an Enzyme‐linked immunosorbent assay for detection of subclinical cases of caseous lymphadenitis in small ruminant flocks

“…This mechanism cause plasma flow from inside the vessels to lymph nodes and for increased vascular permeability. PLD is resposible for many biologic actions such as dermo necrosis, destruction of macrophages in goat's infections, interferes with the process of chemotaxis of neutrophils in sheep and is lethal to phagocytic cells, actions that contributes to the dissemination of the agent from the point of infection to other parts of the organism (Aquino de Sá et al, 2013;Smith Bradford, 2015;Mahmood et al, 2016 The disease occurs worldwide with high prevalence values and causes serious economic losses, particularly in sheep farms and it is more evident in small producers (Al-Gaabary, Osman, Ahmed, & Oreiby, 2010;Aquino de Sá et al, 2013;Arsenault et al, 2003;Jung et al, 2015;Malone et al, 2006;Zavoshti, Khoojine, Helan, Hassanzadeh, & Heydari, 2012). CLA is considered one of the most important diseases, in economic terms, of sheep and goats in the USA, Canada and Brazil causing significant losses in countries where the disease is considered endemic (Çetinkaya et al, 2002;Farias et al, 2019;Guimarães, 2011;Latif et al, 2016;Paton, 2003;Pavan, Robles, Cairó, Marcelino, & Pettinari, 2011;Windsor, 2014).…”

Corynebacterium pseudotuberculosis mastitis in Egyptian dairy goats

“…C. pseudotuberculosis mastitis was reported in cattle [15,16]. C. pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) [17], characterized by abscess formation in several organs in small ruminants [18]. CLA is a worldwide distributed disease [19], which causes significant financial losses in goat and sheep industry due to decreased milk production, wasting, low reproductive rates, and condemnation of carcasses due to internal abscesses [20,21].…”