Serologie und Klinik der autoimmunhämolytischen Erkrankungen

The Serology of Anti-Tj^a-Like Hemolysins Observed in the Serum of Threatened Aborters in Western Australia

“…The effect of heat on the stability of PCH hemolysins has been reported to fluctuate in some instances by Siebens (8). However, Schubothe (7) and H inz et al (3) conclude that most PCH hemoly sins are probably not affected by heating at 56 °C for 30 min. The results of similar studies on the behaviour of the anti-Tja -like hemolysin show that heating the serum at 56 °C for 30 min comple tely destroyed the hemolytic activity.…”

Cryopathies: A Review

“…) In cold hemolysin syndrome the titers of the Donath-Landsteiner hemolysin vary be¬ tween 1:2 and 1:64102. 114 The following case report serves as an ex¬ ample of cryopathy associated with lupus erythematosus. A 23-year-old Latin American housewife was admitted wih a diagnosis of lupus erythematosus, complicated by pain of the fingers and toes which was aggravated by exposure of cold.…”

“…In severe hemolytic anemia due to cold agglutinins, blood transfusions may be required; warming of the tubing to 37 to 40 C may be necessary. Mistyping and mismatching of blood in cryoglobulinemias and cold agglutinin syndrome due to autoagglutination of erythrocytes36 can be prevented by fourfold washing of the erythrocytes at 40 C 114. The fact that cold agglutinins represent macroglobulins which are sensitive to mercaptanes104,105 has led to the exploration of a possible biochemical approach of the cold agglutinin syndrome: see case report under cold agglutinin dis¬ ease.…”

Current Problems of Chronic Cold Hemagglutinin Disease

“…C. Levin, 1960, 1962 of the beta2M type Ritzmann & Levin, 1961, 1962. the assumption is obvious-which we have already discussed in 1955-that they are paraproteins (Schubothe, 1955(Schubothe, , 1958(Schubothe, , 1959(Schubothe, , 1961(Schubothe, , 1962.…”