Serologically Defined (SD) Locus in Cattle

Amorena, B.; Stone, W. H.

doi:10.1126/science.663645

Cited by 69 publications

(33 citation statements)

References 5 publications

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“…Immune responsiveness and heritable resistance or susceptibility to infection are influenced by the host major histocompatibilty complex (MHC) [107–110]. The Bovine Lymphocyte Antigen (BoLA) refers to the major histocompatibilty complex in bovine species ( Bos taurus and Bos indicus ) [111–113]. Pioneering work suggested that host genetics factors determined cattle susceptibility to BLV infection [114].…”

Section: Preventive and Therapeutic Strategiesmentioning

confidence: 99%

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Rodríguez

Florins

Gillet

et al. 2011

Viruses

173

126

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Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.

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Section: Preventive and Therapeutic Strategiesmentioning

confidence: 99%

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Rodríguez

Florins

Gillet

et al. 2011

Viruses

173

126

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“…Studied independently by C ALDWELL et al (1977), A MORENA & STONE (1978), and S POONER et al (1978), the BoLA Complex encodes for 17 class I antigens (see Proceedings, 1982) controlled by the BoLA-A locus (OLIVER et al, 1981) 2) Genetic linkage between BoLA and the M system Table 2 lists all families relevant to analyses for linkage between BoLA and the M system : the details pertaining to the BoLA genotype, the M genotype, the number of informative matings, and the segregation of the gametes within the offspring. The genes for M' and M, was inherited respectively from 6 sires and from 6 sires and 1 cow.…”

Section: Introductionmentioning

confidence: 99%

Linkage in cattle between the major histocompatibility complex (BoLA) and the M blood group system

LEVEZIEL¹,

HINES²

1984

Genet. Sel. Evol.

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SummaryRelationships between the bovine Major Histocompatibility Complex (MHC) and 11 blood group systems were examined using genetic information obtained from 58 families with doubly-heterozygous parents. The data were analyzed by the lod-score method: Close to moderate linkage between the cattle MHC (BoLA complex) and 10 blood group loci, A, B, C, F, J, L, S, Z, R' and T' was excluded. Evidence for a close linkage between BoLA and the M blood group system is presented and a recombination frequency of 0.04 was estimated. The possibility of a linkage disequilibrium in the BoLA-M system chromosomal region is suggested.

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“…In cattle, the first evidence for the existence of a MHC system was found by lymphocyte immunizations and by the generation of monospecific antilymphocyte antisera against skin grafts, followed by studies on the inheritance of the antigens they detected [22,23]. As in the human, the BoLA locus is highly complex and contains about 154 predicted functional genes spanning about 4 centimorgan on chromosome 23 [24].…”

Section: The Major Histocompatibility Complex In Cattlementioning

confidence: 99%

Major Histocompatibility Complex-Associated Resistance to Infectious Diseases: The Case of Bovine Leukemia Virus Infection

Gutiérrez¹,

Esteban²,

Lützelschwab³

et al. 2017

Trends and Advances in Veterinary Genetics

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The major histocompatibility complex (MHC) is a polymorphic gene cluster of about 150 genes, present in all vertebrates. Many of these genes contribute to immunity. Particularly, MHC-encoded class I and class II molecules, which are typically highly polymorphic and polygenic, are central in defining the specificity of the adaptive immune response. Among the diversity of genes associated with disease resistance, MHC genes are particularly interesting as they are associated with resistance and susceptibility to a wide range of diseases, some of which produce important economic losses in livestock. Enzootic bovine leukosis is an infectious disease caused by the retrovirus bovine leukemia virus (BLV), with an important economic impact, mainly in dairy herds. In this chapter, MHC-associated genetic resistance to BLV is revised. Certain alleles of the bovine MHC (BoLA) class II locus have been found strongly associated with resistance to viral dissemination. Genetic selection of resistant animals emerges as a natural strategy for the control of infectious diseases, especially when there is no other alternative of control or prevention, as vaccines. Founded on this knowledge, a BLV control program based on selection of genetically resistant cattle was designed. The proof of concept indicates that this strategy is feasible to implement in dairy herds.

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Serologically Defined (SD) Locus in Cattle

Cited by 69 publications

References 5 publications

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Linkage in cattle between the major histocompatibility complex (BoLA) and the M blood group system

Major Histocompatibility Complex-Associated Resistance to Infectious Diseases: The Case of Bovine Leukemia Virus Infection

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