Serological Survey of Getah Virus in Domestic Animals in Yunnan Province, China

Li, Yuanyuan; Fu, Shihong; Guo, Xin; Li, Xiaolong; Li, Minghua; Wang, Lihua; Gao, Xiaoyan; Lei, Wenwen; Cao, Lei; Lü, Zhi; He, Ying; Wang, Huanyu; Zhou, Hongning; Liang, Guodong

doi:10.1089/vbz.2018.2273

Cited by 35 publications

(45 citation statements)

References 9 publications

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“…The latest GETV outbreak occurred on a swine farm in Hunan, China, in June and July 2017 [9]. Serological surveys have shown that infections have occurred in multiple vertebrate species, including pigs, cattle and poultry, in Yunnan Province [16]. There is evidence that the virus can infect humans and cause fever [7] .…”

Section: Introductionmentioning

confidence: 99%

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First isolation and characterization of Getah virus from cattle in northeastern China

Líu

Zhang

et al. 2019

BMC Vet Res

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Background Getah virus (GETV) is a neglected mosquito-borne Alphavirus that causes pyrexia, body rash, and leg oedema in horses and foetal death and reproductive disorders in pigs. Infected animals may play a critical role in the amplification and circulation of the virus. The present study aimed to investigate GETV infection in clinically infected cattle and vector mosquito species in northeastern China. Results Serum samples were collected from beef cattle that presented sudden onset of fever in forest grazing areas, and metagenomic sequencing was conducted, revealing 29 contigs from ten serum samples matching the GETV genome. Quantitative RT-PCR (RT-qPCR) was performed with GETV RNA from 48 beef cattle serum samples, showing that the overall prevalence of GETV in the beef cattle samples was 6.25% (3/48). Serological investigation indicated that GETV neutralizing antibodies were detected in 83.3% (40/48, 95% CI 67–100) of samples from the study region. The GETV JL1808 strain was isolated from clinically infected cattle showing fever. Sequence comparisons showed high identity with the HuN1 strain, a highly pathogenic swine epidemic isolate obtained in Hunan province in 2017, at the nucleotide level (99.5%) and at the deduced amino acid level (99.7–99.9%). The phylogenetic analysis of JL1808 clustered in Group III, and also revealed a close genetic relationship with the HuN1 strain. Additionally, about 12,000 mosquitoes were trapped in this region. The presence of GETV infection was detected in mosquitoes, suggesting that the minimum infection rate (MIR) was 1.50‰, with MIRs of 1.67‰ in Culex pseudovishnui , 1.60‰ in Culex tritaeniorhynchus , and 1.21‰ in Anopheles sinensis . Conclusions To the best of our knowledge, this is the first report of GETV infection in cattle. These results demonstrated that a highly pathogenic, mosquito-borne swine GETV can infect and circulate in cattle, implying that it is necessary to conduct surveillance of GETV infection in animals in northeastern China. Electronic supplementary material The online version of this article (10.1186/s12917-019-2061-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

“…Up to now, there is only serological evidence supporting the presence of antibodies against GETV in beef cattle with a positive rate of 72% (23/32) in Yunnan Province in 2015 [16]. There has been no report of the isolation of GETV from cattle in Jilin province.…”

Section: Introductionmentioning

confidence: 99%

First isolation and characterization of Getah virus from cattle in northeastern China

Líu

Zhang

et al. 2019

BMC Vet Res

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“…Getah virus (GETV; genus Alphavirus , family Togaviridae ) is a mosquitoborne RNA virus that causes death in young piglets, miscarriage in pregnant sows, and mild illness in horses ( 1 – 3 ). Serologic surveys show that the infection might occur in cattle, ducks, and chickens ( 4 ); some evidence suggests that GETV can infect humans and cause mild fever ( 5 , 6 ).…”

mentioning

confidence: 99%

“…In China, the disease caused by GETV has only been reported in pigs in Hunan Province, although the virus has been detected in mosquitoes in >10 provinces ( 1 , 4 ). Our study provides evidence that GETV can cause lethal infection in blue foxes.…”

mentioning

confidence: 99%

Highly Pathogenic Swine Getah Virus in Blue Foxes, Eastern China, 2017

Shi¹,

Li²,

Lu³

et al. 2019

Emerg. Infect. Dis.

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“…Outbreaks of GETV infection have occurred among Japanese racehorses (231,232). It is known that GETV also infects cattle, although there is no evidence of illness in the infected cattle (226,233,234). However, cattle may contribute to a GETV endemic as a reservoir.…”

Section: Other Arbovirusesmentioning

confidence: 99%

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

2020

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Epizootic congenital abnormalities caused by Akabane, Aino, and Chuzan viruses have damaged the reproduction of domestic ruminants in East Asia for many years. In the past, large outbreaks of febrile illness related to bovine ephemeral fever and Ibaraki viruses severely affected the cattle industry in that region. In recent years, vaccines against these viruses have reduced the occurrence of diseases, although the viruses are still circulating and have occasionally caused sporadic and small-scaled epidemics. Over a long-term monitoring period, many arboviruses other than the above-mentioned viruses have been isolated from cattle and Culicoides biting midges in Japan. Several novel arboviruses that may infect ruminants (e.g., mosquito-and tick-borne arboviruses) were recently reported in mainland China based on extensive surveillance. It is noteworthy that some are suspected of being associated with cattle diseases. Malformed calves exposed to an intrauterine infection with orthobunyaviruses (e.g., Peaton and Shamonda viruses) have been observed. Epizootic hemorrhagic disease virus serotype 6 caused a sudden outbreak of hemorrhagic disease in cattle in Japan. Unfortunately, the pathogenicity of many other viruses in ruminants has been uncertain, although these viruses potentially affect livestock production. As global transportation grows, the risk of an accidental incursion of arboviruses is likely to increase in previously non-endemic areas. Global warming will also certainly affect the distribution and active period of vectors, and thus the range of virus spreads will expand to higher-latitude regions. To prevent anticipated damages to the livestock industry, the monitoring system for arboviral circulation and incursion should be strengthened; moreover, the sharing of information and preventive strategies will be essential in East Asia.

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Serological Survey of Getah Virus in Domestic Animals in Yunnan Province, China

Cited by 35 publications

References 9 publications

First isolation and characterization of Getah virus from cattle in northeastern China

First isolation and characterization of Getah virus from cattle in northeastern China

Highly Pathogenic Swine Getah Virus in Blue Foxes, Eastern China, 2017

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

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